Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Christina Sizun"'
Autor:
Cédric Diot, Charles-Adrien Richard, Jennifer Risso-Ballester, Davy Martin, Jenna Fix, Jean-François Eléouët, Christina Sizun, Marie-Anne Rameix-Welti, Marie Galloux
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13862 (2023)
Respiratory syncytial virus (RSV) RNA synthesis takes place in cytoplasmic viral factories also called inclusion bodies (IBs), which are membrane-less organelles concentrating the viral RNA polymerase complex. The assembly of IBs is driven by liquid-
Externí odkaz:
https://doaj.org/article/b770b3ae919c41c5ad614c12d9cb1e03
Autor:
Silva Khodjoyan, Deborha Morissette, Fortune Hontonnou, Luis Checa Ruano, Charles-Adrien Richard, Olivier Sperandio, Jean-François Eléouët, Marie Galloux, Philippe Durand, Stéphanie Deville-Foillard, Christina Sizun
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 569 (2022)
The interaction between Respiratory Syncytial Virus phosphoprotein P and nucleoprotein N is essential for the formation of the holo RSV polymerase that carries out replication. In vitro screening of antivirals targeting the N-P protein interaction re
Externí odkaz:
https://doaj.org/article/d8ad240c0c66434ca0da8a9150e34470
Autor:
Sylvain Gervason, Djabir Larkem, Amir Ben Mansour, Thomas Botzanowski, Christina S. Müller, Ludovic Pecqueur, Gwenaelle Le Pavec, Agnès Delaunay-Moisan, Omar Brun, Jordi Agramunt, Anna Grandas, Marc Fontecave, Volker Schünemann, Sarah Cianférani, Christina Sizun, Michel B. Tolédano, Benoit D’Autréaux
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The mechanism of iron-sulfur (Fe-S) cluster biosynthesis is not fully understood. Here, the authors develop a physiologically relevant in vitro model of Fe-S cluster assembly, allowing them to elucidate the sequence of Fe-S cluster synthesis along wi
Externí odkaz:
https://doaj.org/article/0caed53885d74e1e9349cdbf6fc819af
Autor:
Hortense Decool, Lorène Gonnin, Irina Gutsche, Christina Sizun, Jean-François Eléouët, Marie Galloux
Publikováno v:
Viruses, Vol 13, Iss 12, p 2449 (2021)
Pneumoviruses include pathogenic human and animal viruses, the most known and studied being the human respiratory syncytial virus (hRSV) and the metapneumovirus (hMPV), which are the major cause of severe acute respiratory tract illness in young chil
Externí odkaz:
https://doaj.org/article/167324cf0a444aafb8fe3d461c370331
Autor:
Christophe Cardone, Claire-Marie Caseau, Benjamin Bardiaux, Aurélien Thureaux, Marie Galloux, Monika Bajorek, Jean-François Eléouët, Marc Litaudon, François Bontems, Christina Sizun
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1225 (2021)
The phosphoprotein P of Mononegavirales (MNV) is an essential co-factor of the viral RNA polymerase L. Its prime function is to recruit L to the ribonucleocapsid composed of the viral genome encapsidated by the nucleoprotein N. MNV phosphoproteins of
Externí odkaz:
https://doaj.org/article/a64137b10a9842f4b354c6bf8f13e94c
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1537 (2021)
Mononegavirales phosphoproteins (P) are essential co-factors of the viral polymerase by serving as a linchpin between the catalytic subunit and the ribonucleoprotein template. They have highly diverged, but their overall architecture is conserved. Th
Externí odkaz:
https://doaj.org/article/a456525f610045019cfa308c45b85483
RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription.
Autor:
Charles-Adrien Richard, Vincent Rincheval, Safa Lassoued, Jenna Fix, Christophe Cardone, Camille Esneau, Sergei Nekhai, Marie Galloux, Marie-Anne Rameix-Welti, Christina Sizun, Jean-François Eléouët
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006920 (2018)
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in which all the components of the viral RNA polymerase are concentrated. In this work, we show that RSV P protein recruits the essential RSV transcription f
Externí odkaz:
https://doaj.org/article/f5df6a5db0e04e3b8b75242071b90e5a
Autor:
Marie-Lise Blondot, Virginie Dubosclard, Jenna Fix, Safa Lassoued, Magali Aumont-Nicaise, François Bontems, Jean-François Eléouët, Christina Sizun
Publikováno v:
PLoS Pathogens, Vol 8, Iss 5, p e1002734 (2012)
Respiratory syncytial virus (RSV) protein M2-1 functions as an essential transcriptional cofactor of the viral RNA-dependent RNA polymerase (RdRp) complex by increasing polymerase processivity. M2-1 is a modular RNA binding protein that also interact
Externí odkaz:
https://doaj.org/article/9ce5ff1c455d4da78dc075aead552d90
Autor:
Batoul Srour, Sylvain Gervason, Maren Hellen Hoock, Beata Monfort, Kristian Want, Djabir Larkem, Nadine Trabelsi, Gautier Landrot, Andrea Zitolo, Emiliano Fonda, Emilien Etienne, Guillaume Gerbaud, Christina Sophia Müller, Jonathan Oltmanns, Jesse B. Gordon, Vishal Yadav, Malgorzata Kleczewska, Marcin Jelen, Michel B. Toledano, Rafal Dutkiewicz, David P. Goldberg, Volker Schünemann, Bruno Guigliarelli, Bénédicte Burlat, Christina Sizun, Benoit D’Autréaux
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, 2022, 144 (38), pp.17496-17515. ⟨10.1021/jacs.2c06338⟩
Journal of the American Chemical Society, 2022, 144 (38), pp.17496-17515. ⟨10.1021/jacs.2c06338⟩
International audience; Iron−sulfur (Fe−S) clusters are prosthetic groups of proteins biosynthesized on scaffold proteins by highly conserved multi-protein machineries. Biosynthesis of Fe−S clusters into the ISCU scaffold protein is initiated b
SummaryTranslationally Controlled Tumour Protein (TCTP) is a pro-survival factor in tumor cells. TCTP inhibits the mitochondrial apoptosis pathway by potentiating the anti-apoptotic Bcl-2 family members Mcl-1 and Bcl-xL. Specifically, TCTP binds Bcl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cbb60ce7d4b6a9e01d20571a0aa3546
https://doi.org/10.1101/2022.11.05.515280
https://doi.org/10.1101/2022.11.05.515280