Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christina Sawchyn"'
Autor:
Gaëlle Mawambo, Malika Oubaha, Yusuke Ichiyama, Guillaume Blot, Sergio Crespo-Garcia, Agnieszka Dejda, François Binet, Roberto Diaz-Marin, Christina Sawchyn, Mikhail Sergeev, Rachel Juneau, Randal J. Kaufman, El Bachir Affar, Frédérick A. Mallette, Ariel M. Wilson, Przemyslaw Sapieha
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Cellular adaptation to low oxygen tension triggers primitive pathways that ensure proper cell function. Conditions of hypoxia and low glucose are characteristic of injured tissues and hence successive waves of inflammatory cells must be suit
Externí odkaz:
https://doaj.org/article/43e12a5532544c0686ece219c67a0571
Autor:
Jean-François Lemay, Edlie St-Hilaire, Daryl A Ronato, Yuandi Gao, François Bélanger, Sari Gezzar-Dandashi, Aimé Boris Kimenyi Ishimwe, Christina Sawchyn, Dominique Lévesque, Mary McQuaid, François-Michel Boisvert, Frédérick A Mallette, Jean-Yves Masson, Elliot A Drobetsky, Hugo Wurtele
Publikováno v:
PLoS Biology, Vol 20, Iss 10, p e3001543 (2022)
Helix-destabilizing DNA lesions induced by environmental mutagens such as UV light cause genomic instability by strongly blocking the progression of DNA replication forks (RFs). At blocked RF, single-stranded DNA (ssDNA) accumulates and is rapidly bo
Externí odkaz:
https://doaj.org/article/a406ab3b3aab4c1790f2cb75bdd9eeda
Autor:
Mathieu Neault, Charles-Étienne Lebert-Ghali, Marilaine Fournier, Caroline Capdevielle, Elizabeth A.R. Garfinkle, Alyssa Obermayer, Anitria Cotton, Karine Boulay, Christina Sawchyn, Kamy H. Nguyen, Béatrice Assaf, François E. Mercier, Jean-Sébastien Delisle, Elliot A. Drobetsky, Laura Hulea, Timothy I. Shaw, Johannes Zuber, Tanja A. Gruber, Heather J. Melichar, Frédérick A. Mallette
Pediatric acute megakaryoblastic leukemia (AMKL) is an aggressive, uncurable blood cancer associated with poor therapeutic response and high mortality. We developed CBFA2T3-GLIS2-driven mouse models of AMKL that recapitulate the phenotypic and transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97f49e34346fda3cc52cee24850c699a
https://doi.org/10.1101/2022.12.16.520129
https://doi.org/10.1101/2022.12.16.520129
Autor:
François Bélanger, Cassandra Roussel, Christina Sawchyn, Sari Gezzar-Dandashi, Aimé Boris Kimenyi Ishimwe, Frédérick Antoine Mallette, Hugo Wurtele, Elliot Drobetsky
Nucleotide excision repair (NER) eliminates highly-genotoxic solar UV-induced DNA photoproducts that otherwise stimulate malignant melanoma development. Here, a genome-wide loss-of-function screen, coupling CRISPR/Cas9 technology with a flow cytometr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4879fb9496f0907c2ec57613c392032
https://doi.org/10.1101/2022.04.14.488378
https://doi.org/10.1101/2022.04.14.488378
Autor:
Jean-François Lemay, Edlie St-Hilaire, Sari Gezzar-Dandashi, Mary McQuaid, Daryl A. Ronato, Yuandi Gao, François Bélanger, Christina Sawchyn, Aimé Boris Kimenyi Ishimwe, Frédérick A. Mallette, Jean-Yves Masson, Elliot A. Drobetsky, Hugo Wurtele
Helix-destabilizing DNA lesions induced by environmental mutagens such as UV light cause genomic instability by strongly blocking the progression of DNA replication forks (RF). At blocked RF, single-stranded DNA (ssDNA) accumulates and is rapidly bou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd1e1f02b03a3fc4f27e925c303f17a3
https://doi.org/10.1101/2022.01.17.476707
https://doi.org/10.1101/2022.01.17.476707
Autor:
Rémi Laflamme, Frédérick A. Mallette, Severine Leclerc, Florian Sennlaub, Christina Sawchyn, Roberto Diaz-Marin, Gael Cagnone, Masayuki Hata, Flavio A. Rezende, Mathieu Neault, Jean-Sébastien Joyal, Ariel M. Wilson, Vera Guber, Agnieszka Dejda, Joel P. Howard, Przemyslaw Sapieha, Sergio Crespo-Garcia, Afnan Abu-Thuraia, Francois Binet, Jean-François Côté, Célia Parinot, Rachel Juneau, Gaelle Mawambo, Frédérique Pilon, Karine Boulay, Gregor Andelfinger, Manuel Buscarlet
Publikováno v:
Science. 369
In developed countries, the leading causes of blindness such as diabetic retinopathy are characterized by disorganized vasculature that can become fibrotic. Although many such pathological vessels often naturally regress and spare sight-threatening c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ae385f0c31eb45591d3ada7eb2384f
https://doi.org/10.1126/science.aay5356
https://doi.org/10.1126/science.aay5356
Autor:
Judith Campisi, Frédérick A. Mallette, Aurélie Martinez, Christina Sawchyn, Nicolas Malaquin, Francis Rodier, Stéphanie Nadeau, Jean-Philippe Coppe, Guillaume B Cardin, Marc-Alexandre Olivier
Publikováno v:
EMBO Rep
Senescent cells display senescence‐associated (SA) phenotypic programs such as stable proliferation arrest (SAPA) and a secretory phenotype (SASP). Senescence‐inducing persistent DNA double‐strand breaks (pDSBs) cause an immediate DNA damage re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01d03f09a0e0dff677f313b9914a8af
https://doi.org/10.15252/embr.202050718
https://doi.org/10.15252/embr.202050718
Autor:
Johannes Zuber, Francois Mercier, Erlinda Fernandez-Diaz, Sonia Cellot, Florence Couteau, Marie-Eve Lalonde, Frédérick A. Mallette, Christina Sawchyn, Karine Boulay, Dagmar Glatz
Publikováno v:
Experimental Hematology. 76:e2-e3
In Canada, almost one third of childhood cancers are leukemias. Encouragingly, many of these pediatric leukemias are now treatable with a variety of anti-cancer drugs. Nonetheless, leukemia still accounts for an alarming ∼25% of cancer-related deat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e513054570f9db902517536557ddfcf8
https://doi.org/10.1016/j.exphem.2019.09.010
https://doi.org/10.1016/j.exphem.2019.09.010
Autor:
Jean-Sébastien Delisle, Anne-Claude Gingras, Karine Boulay, Heather J. Melichar, Mathieu Neault, Payman Samavarchi-Tehrani, Johannes Zuber, Charles-Étienne Lebert-Ghali, Frédérick A. Mallette, Elliot Drobetsky, Marilaine Fournier, Christina Sawchyn
Publikováno v:
Experimental Hematology. 64:S89-S90
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7936c40b1cdf6391b5904c9e53a6c67f
https://doi.org/10.1016/j.exphem.2018.06.106
https://doi.org/10.1016/j.exphem.2018.06.106
Autor:
Mathieu Neault, Marilaine Fournier, Karine Boulay, Elliot Drobetsky, Frédérick A. Mallette, Johannes Zuber, Christina Sawchyn, Heather J. Melichar, Jean-Sébastien Delisle, Charles-Étienne Lebert-Ghali
Publikováno v:
Experimental Hematology. 76:S81
Non-down syndrome pediatric acute megakaryoblastic leukemia (AMKL, AML M7; FAB classification) is an aggressive disease, and classical protocols used for the treatment of AML in children with AMKL have proven unsuccessful. This is largely due to curr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f857cfe468e5d7a81520c686e5f1740
https://doi.org/10.1016/j.exphem.2019.06.414
https://doi.org/10.1016/j.exphem.2019.06.414