Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Christina S. Winborn"'
Autor:
Samantha S. Olah, Dean J. Kareemo, William C. Buchta, Brooke L. Sinnen, Carley N. Miller, Hannah S. Actor-Engel, Sara E. Gookin, Christina S. Winborn, Mason S. Kleinjan, Kevin C. Crosby, Jason Aoto, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113331- (2023)
Summary: Neurotransmitter receptors partition into nanometer-scale subdomains within the postsynaptic membrane that are precisely aligned with presynaptic neurotransmitter release sites. While spatial coordination between pre- and postsynaptic elemen
Externí odkaz:
https://doaj.org/article/3444965cf8894b45b28692c79eca5faf
Autor:
Isaac J Jensen, Christina S Winborn, Micaela G Fosdick, Peng Shao, Mikaela M Tremblay, Qiang Shan, Sandeep Kumar Tripathy, Christopher M Snyder, Hai-Hui Xue, Thomas S Griffith, Jon C Houtman, Vladimir P Badovinac
Publikováno v:
PLoS Pathogens, Vol 14, Iss 10, p e1007405 (2018)
The sepsis-induced cytokine storm leads to severe lymphopenia and reduced effector capacity of remaining/surviving cells. This results in a prolonged state of immunoparalysis, that contributes to enhanced morbidity/mortality of sepsis survivors upon
Externí odkaz:
https://doaj.org/article/03b923b0ce134deaa8ed4995b5e1b679
Autor:
Jennifer N. Bourne, Samantha L Schwartz, Olga Prikhodko, Alexandra Lucas, Kevin C. Crosby, Harrison J. Ramsay, Christina S. Winborn, Brooke L. Sinnen, Hannah S. Actor-Engel, Mark L. Dell'Acqua, Katherine R. Smith, Matthew J. Kennedy
Publikováno v:
eNeuro
Secreted amyloid-β (Aβ) peptide forms neurotoxic oligomeric assemblies thought to cause synaptic deficits associated with Alzheimer's disease (AD). Soluble Aβ oligomers (Aβo) directly bind to neurons with high affinity and block plasticity mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3cd662ac39a6426dae965e984308ba
https://pubmed.ncbi.nlm.nih.gov/34789478
https://pubmed.ncbi.nlm.nih.gov/34789478
Autor:
Aaron B. Bowen, Christina S. Winborn, Dean J Kareemo, Thomas Schwarz, Amos Gutnick, Mason S Kleinjan, Samantha L Schwartz, Ashley M. Bourke, Matthew J. Kennedy
Publikováno v:
The Journal of cell biology. 220(9)
Here we introduce zapalog-mediated endoplasmic reticulum trap (zapERtrap), which allows one to use light to precisely trigger forward trafficking of diverse integral membrane proteins from internal secretory organelles to the cell surface with single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8663b67731fceb23935c6cfd0b702d2f
https://pubmed.ncbi.nlm.nih.gov/34241635
https://pubmed.ncbi.nlm.nih.gov/34241635
Autor:
Christina S. Winborn, Isaac J. Jensen, Vladimir P. Badovinac, Derek B. Danahy, Thomas S. Griffith, Samarchith P. Kurup, John T. Harty
Publikováno v:
J Immunol
Patients who survive sepsis experience long-term immunoparalysis characterized by numerical and/or functional lesions in innate and adaptive immunity that increase the host’s susceptibility to secondary complications. The extent to which tumor deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580a5660d54a67b18ccd53c452590219
https://pubmed.ncbi.nlm.nih.gov/31189573
https://pubmed.ncbi.nlm.nih.gov/31189573
Autor:
John T. Harty, Ramakrishna Sompallae, Vladimir P. Badovinac, Matthew D. Martin, Christina S. Winborn
Publikováno v:
Cell reports
SUMMARY Enhanced host protection against re-infection requires generation of memory T cells of sufficient quantity and functional quality. Unlike well-studied inbred mice, T cell responses of diverse size and quality are generated following infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6b5b39c365387907c9b2d9c4820310
https://doi.org/10.1016/j.celrep.2020.03.072
https://doi.org/10.1016/j.celrep.2020.03.072
Autor:
Christina S. Winborn, Thomas S. Griffith, Mikaela M. Tremblay, Christopher M. Snyder, Sandeep K. Tripathy, Qiang Shan, Micaela G. Fosdick, Hai-Hui Xue, Peng Shao, Jon C. D. Houtman, Isaac J. Jensen, Vladimir P. Badovinac
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 10, p e1007405 (2018)
PLoS Pathogens, Vol 14, Iss 10, p e1007405 (2018)
The sepsis-induced cytokine storm leads to severe lymphopenia and reduced effector capacity of remaining/surviving cells. This results in a prolonged state of immunoparalysis, that contributes to enhanced morbidity/mortality of sepsis survivors upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122ae43542847f7b6241834dcf44ea5d
https://pubmed.ncbi.nlm.nih.gov/30379932
https://pubmed.ncbi.nlm.nih.gov/30379932
Autor:
Jinggang Yin, Quynh T. Tran, John C. Lang, Christina S. Winborn, Fridtjof Thomas, Edward Chaum
Publikováno v:
Natural Science. :558-570
The purpose of this study was to characterize the potential of vitamins to protect the retinal pig-ment epithelium (RPE) from oxidative stress (OS). We have previously shown that OS induces the expression of AP1 transcription factors (FOSB, CFOS and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76eb2ddaaa03ee9dbf8243449adc6a1c
https://doi.org/10.4236/ns.2015.712056
https://doi.org/10.4236/ns.2015.712056
Autor:
Alison J. Clare, Rebecca B. Smith, Siddharthan Chandran, J. Paul Taylor, Luis A. Williams, Christopher Shaw, Steve S.W. Han, Brian D. Freibaum, Nisha M. Badders, Brett J. Winborn, Kevin Eggan, Tom Maniatis, Anderson P. Kanagaraj, Monica A. Carrasco, Evangelos Kiskinis, Edward Chaum, Christina S. Winborn, Nael H. Alami, Bilada Bilican
Publikováno v:
Neuron. 81:536-543
SummaryThe RNA-binding protein TDP-43 regulates RNA metabolism at multiple levels, including transcription, RNA splicing, and mRNA stability. TDP-43 is a major component of the cytoplasmic inclusions characteristic of amyotrophic lateral sclerosis an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6a0a94310afe1bdd1ea0a170e62dd9
https://doi.org/10.1016/j.neuron.2013.12.018
https://doi.org/10.1016/j.neuron.2013.12.018
Publikováno v:
The Journal of Neuroscience. 27:2693-2703
The neuropeptide calcitonin gene-related peptide (CGRP) from the trigeminal ganglion has been established as a key player in the pathogenesis of migraine. In this study, we provide evidence that the responsiveness of neuronal CGRP receptors is strong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8127fe9a81959a5f31c094e12ac85b91
https://doi.org/10.1523/jneurosci.4542-06.2007
https://doi.org/10.1523/jneurosci.4542-06.2007