Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Christina R Ross"'
Autor:
Megan R Majocha, Devin E Jackson, Ngoc-Han Ha, Ruhul Amin, Marie Pangrácová, Christina R Ross, Howard H Yang, Maxwell P Lee, Kent W Hunter
Publikováno v:
PLoS Genetics, Vol 20, Iss 5, p e1011236 (2024)
Patients with ER-negative breast cancer have the worst prognosis of all breast cancer subtypes, often experiencing rapid recurrence or progression to metastatic disease shortly after diagnosis. Given that metastasis is the primary cause of mortality
Externí odkaz:
https://doaj.org/article/6290cedd334c4525803ae30e670a3c1c
Autor:
Dig B Mahat, Sarah E Brennan-Laun, Elizabeth J Fialcowitz-White, Aparna Kishor, Christina R Ross, Tatyana Pozharskaya, J David Rawn, Perry J Blackshear, Bret A Hassel, Gerald M Wilson
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33194 (2012)
The serine/threonine kinase Pim-1 directs selected signaling events that promote cell growth and survival and is overexpressed in diverse human cancers. Pim-1 expression is tightly controlled through multiple mechanisms, including regulation of mRNA
Externí odkaz:
https://doaj.org/article/61aaa13dc15c4d88a7caee877e2788a9
Autor:
Li Xu, Jianguo Liu, William S. M. Wold, Weiguang Cui, Lin Wei, Gerald M. Wilson, Huan Ning, Ling Gu, Christina R. Ross, Baoling Ying, Qinghong Wang, Wenbao Lu, Hui Peng
Publikováno v:
Oncotarget
The main characteristic of cancers, including breast cancer, is the ability of cancer cells to proliferate uncontrollably. However, the underlying mechanisms of cancer cell proliferation, especially those regulated by the RNA binding protein tristetr
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1715-1717
Halogenated thieno[3,2-d]pyrimidines exhibit antiproliferative activity against a variety of cancer cell models, such as the mouse lymphocytic leukemia cell line L1210 in which they induce apoptosis independent of cell cycle arrest. Here we assessed
Autor:
Kartik W. Temburnikar, Christina R. Ross, Gerald M. Wilson, Jan Balzarini, Brian M. Cawrse, Katherine L. Seley-Radtke
In vitro evaluation of the halogenated pyrrolo[3,2-d]pyrimidines identified antiproliferative activities in compounds 1 and 2 against four different cancer cell lines. Upon screening of a series of pyrrolo[3,2-d]pyrimidines, the 2,4-Cl compound 1 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64928445729ae8931c01800a18157c6b
https://europepmc.org/articles/PMC5661880/
https://europepmc.org/articles/PMC5661880/
Autor:
Christina R. Ross, Beth E. Zucconi, Vicki H. Wysocki, Daniel Deredge, Michael R. White, Mohd M. Khan, Royston S. Quintyn, Patrick L. Wintrode, Elsa D. Garcin, Gerald M. Wilson
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an enzyme best known for its role in glycolysis. However, extra-glycolytic functions of GAPDH have been described, including regulation of protein expression via RNA binding. GAPDH binds to numerous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58624635bb445d94fb4660c82cd5a50
https://europepmc.org/articles/PMC4326822/
https://europepmc.org/articles/PMC4326822/
Publikováno v:
Ageing research reviews. 11(4)
Cancer and senescence are both complex transformative processes that dramatically alter many features of cell physiology and their interactions with surrounding tissues. Developing the wide range of cellular features characteristic of these condition
Autor:
Eric A. Toth, Christina R. Ross, Jun Huang, Jeff D. Ballin, Brandy Y. Brewer, Beth E. Zucconi, Gerald M. Wilson
AU-rich element RNA-binding protein 1 (AUF1) binding to AU-rich elements (AREs) in the 3′-untranslated regions of mRNAs encoding many cytokines and other regulatory proteins modulates mRNA stability, thereby influencing protein expression. AUF1-mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408312950e288d715a5370ba79dc8a63
https://europepmc.org/articles/PMC2998080/
https://europepmc.org/articles/PMC2998080/
Autor:
James P. Prevas, Gerald M. Wilson, Jeff D. Ballin, M. Thomas Record, Christina R. Ross, Eric A. Toth
Publikováno v:
Biochemistry. 49(9)
Interactions of histidine with nucleic acid phosphates and histidine pK(a) shifts make important contributions to many protein-nucleic acid binding processes. To characterize these phenomena in simplified systems, we quantified binding of a histidine
Autor:
Gerald M. Wilson, Christina R. Ross
Publikováno v:
Cancer Research. 75:1970-1970
The purpose of this study was to define mechanisms by which the mRNA-destabilizing factor tristetraprolin (TTP) impacts tumorigenic phenotypes in an aggressive model of metastatic breast cancer. Widespread repression of TTP levels in human tumors and