Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Christina Nadolny"'
Autor:
Sangmin You, Ai-Min Cui, Syed F. Hashmi, Xinmu Zhang, Christina Nadolny, Yuan Chen, Qiwen Chen, Xin Bush, Zachary Hurd, Winifer Ali, Gang Qin, Ruitang Deng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Preterm birth (PTB) is the leading cause of perinatal mortality and newborn complications with limited treatment options. Here the authors show that dysregulation of bile acids increases risk for PTB in pregnant women while restoring bile acid homeos
Externí odkaz:
https://doaj.org/article/722b7169c06244cc8e509e24c665a7d2
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170960 (2017)
Δ4-3-oxosteroid 5β-reductase is member D1 of the aldo-keto reductase family 1 (AKR1D1), which catalyzes 5β-reduction of molecules with a 3-oxo-4-ene structure. Bile acid intermediates and most of the steroid hormones carry the 3-oxo-4-ene structur
Externí odkaz:
https://doaj.org/article/a18a83b90f8446dea9fae35172921522
Autor:
Christina Nadolny
Liver cancer is in the ten leading cancer types for estimated new cases and deaths in the United States in 2018, and is often detected at late stages when it is rapidly fatal. Of the types of liver cancers in humans, hepatocellular carcinoma (HCC) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::093366d208d7d9f88413d8b408950a97
https://doi.org/10.23860/diss-nadolny-christina-2018
https://doi.org/10.23860/diss-nadolny-christina-2018
Autor:
Ai-Min Cui, Christina Nadolny, Yuan Chen, Qiwen Chen, Ruitang Deng, Sangmin You, Winifer Ali, Syed F. Hashmi, Zachary Hurd, Xin Bush, Gang Qin, Xinmu Zhang
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Preterm birth (PTB) is the leading cause of perinatal mortality and newborn complications. Bile acids are recognized as signaling molecules regulating a myriad of cellular and metabolic activities but have not been etiologically linked to PTB. In thi
Autor:
Yuan Chen, Christina Nadolny, Sangmin You, Mwlod Ghareeb, Liangran Guo, Ruitang Deng, Stephanie Shiffka, Ruchi Verma, Leila Valanejad, Fatemeh Akhlaghi
Publikováno v:
Molecular and Cellular Endocrinology. 470:127-141
Aldo-keto reductase family 1 member D1 (AKR1D1) is a Δ4-3-oxosteroid 5β-reductase required for bile acid synthesis and steroid hormone metabolism. Both bile acids and steroid hormones, especially glucocorticoids, play important roles in regulating
Autor:
Xiaoqun Dong, Christina Nadolny
Publikováno v:
Cancer Biology & Therapy. 16:997-1004
Liver receptor homolog-1 (LRH-1) is a nuclear receptor involved in various biological processes. This nuclear receptor has critical functions in embryonic development as well as in adult homeostasis. Although the physiological functions of LRH-1 in n
Autor:
Xiulong Song, Yuan Chen, Ruchi Verma, Alex Vasilenko, Stephanie Shiffka, Bingfang Yan, Ruitang Deng, Leila Valanejad, Leeza Hargreaves, Christina Nadolny, Sangmin You
Publikováno v:
Molecular Endocrinology. 29:613-626
Among diseases unique to pregnancy, intrahepatic cholestasis of pregnancy is the most prevalent disorder with elevated serum bile acid levels. We have previously shown that estrogen 17β-estradiol (E2) transrepresses bile salt export pump (BSEP) thro
Autor:
Leila, Valanejad, Mwlod, Ghareeb, Stephanie, Shiffka, Christina, Nadolny, Yuan, Chen, Liangran, Guo, Ruchi, Verma, Sangmin, You, Fatemeh, Akhlaghi, Ruitang, Deng
Publikováno v:
Molecular and cellular endocrinology. 470
Aldo-keto reductase family 1 member D1 (AKR1D1) is a Δ(4)-3-oxosteroid 5β-reductase required for bile acid synthesis and steroid hormone metabolism. Both bile acids and steroid hormones, especially glucocorticoids, play important roles in regulatin
Autor:
Qiushi Lin, Shaofan Weng, Zheping Huang, Arihiro Aihara, Christina Nadolny, Waihong Chung, Yu Li, Jack R. Wands, Xuesong Chen, Rolf I. Carlson, Xiaoqun Dong
Publikováno v:
Cancer Lett
The transcriptional factor liver receptor homolog 1 (LRH1) regulates pancreatic development, and may participate in pancreatic oncogenesis through activation of growth factor signaling transduction cascades. We measured transcriptional activity of β
Autor:
Qingwei Meng, Hongbin Wang, Hailin Li, Li Cai, Xiaoqun Dong, Hailing Lu, Mengru Cao, Xiuli Li, Hui Pang, Christina Nadolny, Yanbin Zhao
Publikováno v:
Journal of Cellular Physiology. 229:1855-1862
Angiotensin II (Ang II), a biologically active peptide of the renin-angiotensin system (RAS), plays an important role in promoting cell migration via Angiotensin II type 1 receptor (AT1R). In this study, we examined the mechanisms by which Ang II aff