Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Christina N. Zdenek"'
Autor:
Christina N. Zdenek, Fernanda C. Cardoso, Samuel D. Robinson, Raine S. Mercedes, Enriko R. Raidjõe, María José Hernandez-Vargas, Jiayi Jin, Gerardo Corzo, Irina Vetter, Glenn F. King, Bryan G. Fry, Andrew A. Walker
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110723- (2024)
Summary: Kissing bugs are known to produce anticoagulant venom that facilitates blood-feeding. However, it is unknown how this saliva evolved and if the venom produced by the entomophagous ancestors of kissing bugs would have helped or hindered the t
Externí odkaz:
https://doaj.org/article/c7ebb8f5f71349499699a1a3ac14234a
Autor:
Uthpala Chandrasekara, Abhinandan Chowdhury, Lorenzo Seneci, Christina N. Zdenek, Nathan Dunstan, Bryan G. Fry
Publikováno v:
Toxins, Vol 16, Iss 10, p 430 (2024)
Australian elapid snake venoms are uniquely procoagulant, utilizing blood clotting enzyme Factor Xa (FXa) as a toxin, which evolved as a basal trait in this clade. The subsequent recruitment of Factor Va (FVa) as a toxin occurred in the last common a
Externí odkaz:
https://doaj.org/article/229086f38e7d45ae8b430c975e621659
Autor:
Uthpala Chandrasekara, Marco Mancuso, Lorenzo Seneci, Lachlan Bourke, Dane F. Trembath, Joanna Sumner, Christina N. Zdenek, Bryan G. Fry
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2628 (2024)
The interplay between predator and prey has catalyzed the evolution of venom systems, with predators honing their venoms in response to the evolving resistance of prey. A previous study showed that the African varanid species Varanus exanthematicus h
Externí odkaz:
https://doaj.org/article/1167a6aac8dc4202a07232edd2cd1b73
Autor:
Christina N. Zdenek, Caroline F. B. Rodrigues, Lachlan A. Bourke, Anita Mitico Tanaka-Azevedo, Paul Monagle, Bryan G. Fry
Publikováno v:
Toxins, Vol 15, Iss 2, p 158 (2023)
Snakebite is a globally neglected tropical disease, with coagulation disturbances being the primary pathology of many deadly snake venoms. Age-related differences in human plasma have been abundantly reported, yet the effect that these differences po
Externí odkaz:
https://doaj.org/article/a212adce57b84b928184eb2a5aa2c2ba
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
African spitting cobras are unique among cobras for their potent anticoagulant venom activity arising from strong inhibition of Factor Xa. This anticoagulant effect is exerted by venom phospholipase A2 (Group I PLA2) toxins whose activity contributes
Externí odkaz:
https://doaj.org/article/6c5b8a7158544a4584538ca992da9c1e
Autor:
Abhinandan Chowdhury, Christina N. Zdenek, Matthew R. Lewin, Rebecca Carter, Tomaž Jagar, Erika Ostanek, Hannah Harjen, Matt Aldridge, Raul Soria, Grace Haw, Bryan G. Fry
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Palearctic vipers are medically significant snakes in the genera Daboia, Macrovipera, Montivipera, and Vipera which occur throughout Europe, Central Asia, Near and Middle East. While the ancestral condition is that of a small-bodied, lowland species,
Externí odkaz:
https://doaj.org/article/c4093c89a64943138728be0ff61fcf2e
Autor:
Lorenzo Seneci, Christina N. Zdenek, Abhinandan Chowdhury, Caroline F. B. Rodrigues, Edgar Neri-Castro, Melisa Bénard-Valle, Alejandro Alagón, Bryan G. Fry
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Rattlesnakes are a diverse clade of pit vipers (snake family Viperidae, subfamily Crotalinae) that consists of numerous medically significant species. We used validated in vitro assays measuring venom-induced clotting time and strength of any clots f
Externí odkaz:
https://doaj.org/article/f49704000112484bb38b4e4d1145bd59
Autor:
Lachlan Allan Bourke, Christina N. Zdenek, Anita Mitico Tanaka-Azevedo, Giovanni Perez Machado Silveira, Sávio Stefanini Sant’Anna, Kathleen Fernandes Grego, Caroline Fabri Bittencourt Rodrigues, Bryan Grieg Fry
Publikováno v:
Toxins, Vol 14, Iss 5, p 297 (2022)
Despite coagulotoxicity being a primary weapon for prey capture by Bothrops species (lancehead pit vipers) and coagulopathy being a major lethal clinical effect, a genus-wide comparison has not been undertaken. To fill this knowledge gap, we used thr
Externí odkaz:
https://doaj.org/article/9ce1dbc524f040a2953bf502937be5ac
Autor:
Richard J. Harris, Christina N. Zdenek, Amanda Nouwens, Charlotte Sweeney, Nathan Dunstan, Bryan G. Fry
Publikováno v:
Toxicon: X, Vol 7, Iss , Pp 100050- (2020)
Contralaterally positioned maxillary (upper jaw) venom glands in snakes are mechanically independent, being able to discharge venom from either gland separately. This has led some studies to test venom function and composition of each contralaterally
Externí odkaz:
https://doaj.org/article/ee5364fbc88047d885fa4f307ce8f5ec
Autor:
James S. Dobson, Richard J. Harris, Christina N. Zdenek, Tam Huynh, Wayne C. Hodgson, Frank Bosmans, Rudy Fourmy, Aude Violette, Bryan G. Fry
Publikováno v:
Toxins, Vol 13, Iss 8, p 549 (2021)
Bites from helodermatid lizards can cause pain, paresthesia, paralysis, and tachycardia, as well as other symptoms consistent with neurotoxicity. Furthermore, in vitro studies have shown that Heloderma horridum venom inhibits ion flux and blocks the
Externí odkaz:
https://doaj.org/article/f2d6df6865f14b40ac3515ead073d67f