Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christina N. Steininger"'
Autor:
James W. Malecha, Christina N. Steininger, Melanie L. Williams, Kristen E. Shannon, Thomas Rogers, Bryan H. Landis, Tiffany Duffin, Srinivasan Nagarajan, Pegg Jodi Ann, Hwang-Fun Lu, Rico Joseph G, Maureen A. Nickols, Jun Zhu, Sandra K. Freeman, V. Wayne Engleman, David W. Griggs, G. Alan Nickols, Jeffery L. Keene, Devadas Balekudru, Debra M. Meyer, Marisa M. Westlin, Larry Miller, Laura D. Marrufo, Nawasa F. Green, Melissa K. Lantz, Mark A. Russell, Peter G. Ruminski, Mary Beth Finn, H. Peter Kleine, Joe T. Collins
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3783-3800
The integrin αvβ3, vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the discovery of a
Autor:
Tiffany Duffin, Maureen A. Nickols, Barbara B. Chen, Mary Beth Finn, Mark A. Russell, William F. Westlin, Steven L. Settle, Mark L. Boys, Randall K. Rader, Jon A. Klover, Wang Yaping, Thomas D. Penning, Jeffery L. Keene, V. Wayne Engleman, G. Allen Nickols, Christina N. Steininger, Sandra K. Freeman, Melanie L. Hanneke, Khilevich Albert, Marisa M. Westlin, Kristen E. Shannon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3156-3161
We describe a series of pyrazole and isoxazole analogs as antagonists of the α v β 3 receptor. Compounds showed low to sub-nanomolar potency against α v β 3 , as well as good selectivity against α IIb β 3 . In HT29 cells, most analogs also demo
Autor:
Mary Beth Finn, Hongwei Wu, Kristen E. Shannon, V. Wayne Engleman, Maureen A. Nickols, Jon A. Klover, Marissa Westlin, Tiffany Duffin, Christina N. Steininger, G. Allen Nickols, Thomas D. Penning, Melanie L. Hanneke, John A. Wendt, Heather Stenmark, Mark A. Russell, Jeffery L. Keene, Downs Victoria Leigh, William F. Westlin, Barbara B. Chen, Wang Yaping, Sandra K. Freeman, Mark L. Boys
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:845-849
We describe a series of 2,5 thiazole containing compounds, which are potent antagonists of the integrin alpha(v)beta3 and show selectivity relative to the other integrins, such as alpha(IIb)beta3 and alpha(v)beta6. These analogs were demonstrated to
Autor:
Christopher R. Dalton, Nizal S. Chandrakumar, Mark L. Boys, G. Allen Nickols, Mark Russell, Maureen A. Nickols, Michael Clare, Dale P. Spangler, John A. Wendt, Christina N. Steininger, William F. Westlin, Yaping Wang, Tiffany Duffin, Michael B. Tollefson, Jon A. Klover, Sandra K. Freeman, Melanie L. Hanneke, Scott B. Mohler, Mary Beth Finn, Maria N. Nguyen, Heather G. Stenmark, Jeffery L. Keene, Hongwei Wu, Bipin N. Desai, Barbara B. Chen, V. Wayne Engleman, Yi X. Yu, Sarah A. Norring, Marisa M. Westlin, Lori A. Schretzman, Downs Victoria Leigh, Ish K. Khanna, Thomas D. Penning
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:839-844
We describe a series of 1,2,4-oxadiazoles, which are potent antagonists of the integrin alpha(v)beta3 and, in addition, show selectivity relative to the other beta3 integrin alpha(IIb)beta3. In whole cells, the majority of these analogs also demonstr
Autor:
Gerald F. Casperson, Pamela A. De Ciechi, Lyle E. Pegg, Catherine S. Devine, Marshall L. Michener, Debra M. Meyer, Christina N. Steininger, Joseph K. Welply, Maire Helena Caparon, Susan C. Howard
Publikováno v:
Proteins: Structure, Function, and Genetics. 26:262-270
A mixed phage library containing random peptides from four to eight residues in length flanked by cysteine residues was screened using a recombinant soluble, form of human ICAM-1, which included residues 1-453, (ICAM-1(1-453)). Phage bound to immobil
Autor:
Tucker Collins, Jon J. Schmuke, Songmei Yin, James H. Williams, Kaizhi Guo, Eunhee S. Yi, Jeffery L. Keene, Joseph K. Welply, Daniel G. Remick, Thomas R. Ulich, Susan C. Howard, Christina N. Steininger
Publikováno v:
Inflammation. 18:389-398
E-selectin is an inducible endothelial adhesion molecule that binds neutrophils. E-selectin mRNA is not constitutively detectable in the lungs of rats. Intratracheal injection of LPS induces pulmonary E-selectin mRNA expression at 2–4 h. Intratrach
Autor:
Christopher A. Eddy, Joseph K. Welply, Christina N. Steininger, Richard M. Leimgruber, Alan Mellors
Publikováno v:
Biochemical and Biophysical Research Communications. 188:760-766
HL-60 cells and neutrophils treated with the glycoprotease from Pasteurella haemolytica A1, an enzyme which is specific for O-sialoglycoproteins, were found to be incapable of binding P-selectin but still bound E-selectin. Comparative analysis of [35
Autor:
Thomas D, Penning, Albert, Khilevich, Barbara B, Chen, Mark A, Russell, Mark L, Boys, Yaping, Wang, Tiffany, Duffin, V Wayne, Engleman, Mary Beth, Finn, Sandra K, Freeman, Melanie L, Hanneke, Jeffery L, Keene, Jon A, Klover, G Allen, Nickols, Maureen A, Nickols, Randall K, Rader, Steven L, Settle, Kristen E, Shannon, Christina N, Steininger, Marisa M, Westlin, William F, Westlin
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(12)
We describe a series of pyrazole and isoxazole analogs as antagonists of the alpha(v)beta3 receptor. Compounds showed low to sub-nanomolar potency against alpha(v)beta3, as well as good selectivity against alpha(IIb)beta3. In HT29 cells, most analogs
Autor:
Christine Kirmaier, Gary S. Jacob, Christina N. Steininger, Susan C. Howard, Peter Richard Scudder, S. Zaheer Abbas, Joseph K. Welply
Publikováno v:
Biochemistry. 34(4)
Fluorescence polarization has been used to directly measure the binding of the tetrasaccharide sialyl Lewisx (sLe(x)[Glc], or NeuAc alpha 2-3Gal beta 1-4[Fuc alpha 1-3]Glc) to a soluble form of E-selectin, a member of the class of adhesion molecules
Autor:
Joseph K. Welply, Broschat K, Jeffery L. Keene, Peter Richard Scudder, S Z Abbas, Christina N. Steininger, Gary S. Jacob, Susan C. Howard, C Kirmaier, Jon J. Schmuke
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461357681
Recruitment of neutrophils to sites of inflammation is now believed to occur through an initial rolling interaction at the luminal surface of activated endothelium and is mediated by a class of mammalian lectins referred to as the selectins. Selectin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e7a3cd75c4f0a25f0959337655af800
https://doi.org/10.1007/978-1-4615-1885-3_31
https://doi.org/10.1007/978-1-4615-1885-3_31