Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Christina Menke"'
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Akademický článek
TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro.
Autor: Christina Menke, Tatiana Goncharov, Lubna Qamar, Christopher Korch, Heide L Ford, Kian Behbakht, Andrew Thorburn
Publikováno v: PLoS ONE, Vol 6, Iss 1, p e14527 (2011)
Signaling by Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) and Fas ligand (FasL) has been proposed to contribute to the chemosensitivity of tumor cells treated with various other anti-cancer agents. However, the importance of these
Externí odkaz: https://doaj.org/article/982b9d87e9544197aed07addf6142ddf
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6
Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent
Autor: Michael J. Morgan, Leah Staskiewicz, Christina Menke, Freddi Gidan, Graciela Gamez, Ariel L. Hernandez, Paola Maycotte, Shellie Morgan, Jacqueline Thorburn, Andrew Thorburn, Christopher Cummings
Publikováno v: Autophagy
Chloroquine (CQ) is an antimalarial drug and late-stage inhibitor of autophagy currently FDA-approved for use in the treatment of rheumatoid arthritis and other autoimmune diseases. Based primarily on its ability to inhibit autophagy, CQ and its deri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61be9dcdf811c2240db6ca9341186def
https://doi.org/10.4161/auto.32135
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7
Distinct TRAIL Resistance Mechanisms Can Be Overcome by Proteasome Inhibition but not Generally by Synergizing Agents
Autor: Christina Menke, Lianghua Bin, Kian Behbakht, Heide L. Ford, Jacqueline Thorburn, Andrew Thorburn
Publikováno v: Cancer Research. 71:1883-1892
One impediment to the use of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-targeted agents as antitumor drugs is the evolution of resistance, a common problem in cancer. On the contrary, many different kinds of drugs synerg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640f395ce457b0aa22f490ee45d3934f
https://doi.org/10.1158/0008-5472.can-10-2252
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8
Abstract B115: Use of a genome-wide loss-of-function screen to identify novel mechanisms of resistance to TRAIL induced apoptosis
Autor: Christina Menke, Aik Choon Tan, Kian Behbakht, Joshua Cabrera, Andrew Thorburn, Jihye Kim, Heide L. Ford, Christopher C. Porter, Lina Y. Dimberg
Publikováno v: Molecular Cancer Therapeutics. 12:B115-B115
A biological approach to combat cancer is to define and specifically target signaling pathways involved in tumor progression and metastasis. One such target is the TNF-Related Apoptosis Inducing Ligand (TRAIL) signaling pathway. Importantly, TRAIL ki
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7430a9da223f07fe6a62078479c3c701
https://doi.org/10.1158/1535-7163.targ-13-b115
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9
Abstract 207: Distinct TRAIL resistance mechanisms can be overcome by proteosome inhibition
Autor: Christina Menke, Jacqueline Thorburn, Kian Behbakht, Lianghua Bin, Andrew Thorburn, Heide L. Ford
Publikováno v: Cancer Research. 70:207-207
A major impediment to the use of Tumor Necrosis Factor-Like Apoptosis Inducing Ligand (TRAIL) Receptor targeted drugs is that many tumors evolve resistance to these agents. On the other hand however, multiple different kinds of drugs are reported to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19990d7991920c27c87723d5819455a3
https://doi.org/10.1158/1538-7445.am10-207
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