A Hyaluronan and Proteoglycan Link Protein 1 Matrikine: Role of Matrix Metalloproteinase 2 in Multiple Myeloma NF-ĸB Activation and Drug Resistance

Autor: Christina Mark, Jay Warrick, Natalie S. Callander, Peiman Hematti, Shigeki Miyamoto

Publikováno v: Mol Cancer Res

The NF-κB signaling pathway plays key roles in inflammation and the pathogenesis of many solid and hematologic malignancies, including multiple myeloma, a malignancy of the plasma cells. While proteasome inhibitors, such as bortezomib, employed in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb597ffa2904a5b85fab9991a815e92e
https://europepmc.org/articles/PMC9444915/

Optimizing regulatory frameworks for gene therapies in rare diseases: Challenges and solutions

Autor: Diane Berry, Kate Donigan, Lisa Kahlman, James Long, Christina Markus, Caitlin K. McCombs

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101386- (2024)

The advent of genetic medicines and advanced diagnostics has revolutionized the treatment landscape for rare diseases and, with over 10,000 identified conditions affecting millions globally, has the potential to improve many lives. Despite this progr

Externí odkaz: https://doaj.org/article/bda47cc3dff0435a969d87b8b625187c

Chronic exercise improves hepatic acylcarnitine handling

Autor: Diego Hernández-Saavedra, J. Matthew Hinkley, Lisa A. Baer, Kelsey M. Pinckard, Pablo Vidal, Shinsuke Nirengi, Andrea M. Brennan, Emily Y. Chen, Niven R. Narain, Valerie Bussberg, Vladimir V. Tolstikov, Michael A. Kiebish, Christina Markunas, Olga Ilkayeva, Bret H. Goodpaster, Christopher B. Newgard, Laurie J. Goodyear, Paul M. Coen, Kristin I. Stanford

Publikováno v: iScience, Vol 27, Iss 3, Pp 109083- (2024)

Summary: Exercise mediates tissue metabolic function through direct and indirect adaptations to acylcarnitine (AC) metabolism, but the exact mechanisms are unclear. We found that circulating medium-chain acylcarnitines (AC) (C12-C16) are lower in act

Externí odkaz: https://doaj.org/article/1fa864323c024e6ea418512ba98137e4

Immobilisation of barley aleurone layers enables parallelisation of assays and analysis of transient gene expression in single cells

Autor: Jenny Emnéus, Claus Krogh Madsen, Christina Mark, Christine Finnie, Arto Heiskanen, Kinga Zor, Henrik Brinch-Pedersen, Martin Dufva

Publikováno v: Zor, K, Mark, C, Heiskanen, A, Madsen, C K, Dufva, M, Emnéus, J, Brinch-Pedersen, H & Finnie, C 2017, ' Immobilisation of barley aleurone layers enables parallelisation of assays and analysis of transient gene expression in single cells ', Plant Physiology and Biochemistry, vol. 118, pp. 71-76 . https://doi.org/10.1016/j.plaphy.2017.06.008

The barley aleurone layer is an established model system for studying phytohormone signalling, enzyme secretion and programmed cell death during seed germination. Most analyses performed on the aleurone layer are end-point assays based on cell extrac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aae732672893188ebc40f0f96b9031c
https://pure.au.dk/portal/da/publications/immobilisation-of-barley-aleurone-layers-enables-parallelisation-of-assays-and-analysis-of-transient-gene-expression-in-single-cells(41e18feb-f5ab-433d-a07d-fe59045f13ed).html

Development and automation of a novel NET-PET tracer: [11C]Me@APPI

Autor: Matthias Hendl, Lukas Nics, Birgit Bornatowicz, Wolfgang Wadsak, Daniela Haeusler, Rupert Lanzenberger, Markus Mitterhauser, Christina Mark, Michael L. Berger, Helmut Spreitzer

Publikováno v: Nuclear medicine and biology. 40(2)

Introduction The norepinephrine transporter (NET) is an important target for research in neurology and psychology and is involved in the pathophysiology of many neurodegenerative diseases such as Alzheimer's disease and attention deficient hyperactiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a807a9f71f413b1a6acc1645216549
https://pubmed.ncbi.nlm.nih.gov/23265665