Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Christina M. Mailloux"'
1
The Glucocorticoid Receptor and KLF15 Regulate Gene Expression Dynamics and Integrate Signals through Feed-Forward Circuitry
Autor: Andrea J. Barczak, Qian Wang, Christina M. Mailloux, Sarah K. Sasse, Mohammed O. Altonsy, Saptarsi M. Haldar, Mukesh K. Jain, Anthony N. Gerber
Publikováno v: Molecular and Cellular Biology. 33:2104-2115
The glucocorticoid receptor (GR) regulates adaptive transcriptional programs that alter metabolism in response to stress. Network properties that allow GR to tune gene expression to match specific physiologic demands are poorly understood. We analyze
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b289e3e03c55b07a9215b111ed0839
https://doi.org/10.1128/mcb.01474-12
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2
Expression Profiling Identifies Klf15 as a Glucocorticoid Target That Regulates Airway Hyperresponsiveness
Autor: Rey A. Panettieri, Mukesh K. Jain, Xiaozhu Huang, Kiriko Masuno, Saptarsi M. Haldar, Darwin Jeyaraj, Anthony N. Gerber, Christina M. Mailloux
Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 45:642-649
Glucocorticoids (GCs), which activate GC receptor (GR) signaling and thus modulate gene expression, are widely used to treat asthma. GCs exert their therapeutic effects in part through modulating airway smooth muscle (ASM) structure and function. How
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adfc7a5f76f6c25808181d5374f6c583
https://doi.org/10.1165/rcmb.2010-0369oc
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3
Development of Murine Lupus Involves the Combined Genetic Contribution of the SLAM and FcγR Intervals within the Nba2 Autoimmune Susceptibility Locus
Autor: Troy E. Metzger, Chao Jiang, Stephanie Atencio, Christina M. Mailloux, Hilda L. Enriquez, Loren D. Erickson, María Rosa Bono, Trine N. Jørgensen, William M. Loo, Jennifer Alfaro, Mario Rosemblatt, Brian L. Kotzin, Shannon Flannery, Stephen J. Rozzo, Melanie R. Gubbels Bupp
Publikováno v: JOURNAL OF IMMUNOLOGY
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Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss of immune tolerance that leads to ant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f764fd65c80285798074a6f585fe15
https://doi.org/10.4049/jimmunol.0901322
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4
LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum
Autor: Kin Ming Kwan, Heiner Westphal, Woon Kyu Lee, Richard R. Behringer, Alexander Grinberg, Christina M. Mailloux, Yangu Zhao, Wolfgang Wurst
Publikováno v: Proc. Natl. Acad. Sci. U.S.A. 104, 13182-13186 (2007)
Purkinje cells are one of the major types of neurons that form the neural circuitry in the cerebellum essential for fine control of movement and posture. During development, Purkinje cells also are critically involved in the regulation of proliferati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf13ed8d9a45789ba87bd465d86f924e
https://doi.org/10.1073/pnas.0705464104
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5
Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo
Autor: Richard A. Spritz, Pamela R. Fain, Christina M. Mailloux, Greggory S. LaBerge, Katherine Gowan, Paulene J. Holland, Dorothy C. Bennett
Publikováno v: Pigment Cell Research. 18:300-305
Generalized vitiligo is an autoimmune disorder in which acquired white patches of skin and overlying hair result from autoimmune loss of melanocytes from involved areas. Although usually sporadic, family clustering of vitiligo may occur, in a non-Men
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a25ccaa153f636f34b3a0eb0d8fa5155
https://doi.org/10.1111/j.1600-0749.2005.00242.x
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6
Common variants in FOXP1 are associated with generalized vitiligo
Autor: Pamela R. Fain, Jo Lambert, Christina M. Mailloux, Ying Jin, Stanca A. Birlea, Andreas Overbeck, Alain Taïeb, Margaret R. Wallace, Mauro Picardo, Sheri L. Riccardi, Dorothy C. Bennett, E. Helen Kemp, Paulene J. Holland, Khaled Ezzedine, Wayne T. McCormack, Anthony P. Weetman, Richard A. Spritz, Giovanni Leone, Nanny van Geel, Katherine Gowan, David J. Gawkrodger, Thomas Jouary
Publikováno v: Nature genetics
In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European desc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5f2ad463b3a776f0624cd385289ea9
https://doi.org/10.1038/ng.602
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7
NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1beta processing via the NLRP1 inflammasome
Autor: Kimberly K. McFann, Pamela R. Fain, Ying Jin, Richard A. Spritz, Paulene J. Holland, Cecilia B. Levandowski, Christina M. Mailloux, Charles A. Dinarello, Tracey M. Ferrara, Songtao Ben, Katherine Gowan
Publikováno v: Proceedings of the National Academy of Sciences USA, 110, 2952-6
Proceedings of the National Academy of Sciences USA, 110, 8, pp. 2952-6
Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a key regulator of the innate immune system, particularly in the skin where, in response to molecular triggers such as pathogen-associated or damage-associated molecular patterns, the NLRP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141929f91c197c0a3d8db89007ba58a9
https://doi.org/10.1073/pnas.1222808110
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9
A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development
Autor: Edit Hermesz, Miklós Palkovits, Yangu Zhao, Christina M. Mailloux, Heiner Westphal
The mammalian pituitary gland originates from two separate germinal tissues during embryonic development. The anterior and intermediate lobes of the pituitary are derived from Rathke's pouch, a pocket formed by an invagination of the oral ectoderm. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6e875798685b47a7f093491d19e711
https://europepmc.org/articles/PMC2832476/
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10
NALP1 in vitiligo-associated multiple autoimmune disease
Autor: Katherine Gowan, Christina M. Mailloux, Sheri L. Riccardi, Pamela R. Fain, Dorothy C. Bennett, Ying Jin, Greggory S. LaBerge, Richard A. Spritz
Publikováno v: The New England journal of medicine. 356(12)
BACKGROUND: Autoimmune and autoinflammatory diseases involve interactions between genetic risk factors and environmental triggers. We searched for a gene on chromosome 17p13 that contributes to a group of epidemiologically associated autoimmune and a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86269343d8bff389fa5e10efbb43a92
https://pubmed.ncbi.nlm.nih.gov/17377166
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