Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Christina M. Lockwood"'
Autor:
Brittany L. Greene, Shannon M. Stasi, Michelle A. Ting, Natalie Waligorski, Bonnie L. Cole, Christina M. Lockwood, Vera A. Paulson, Jillian G. Buchan, Amy Lee, Jeffrey G. Ojemann, Richard G. Ellenbogen, Jeffrey Stevens, Sarah E. S. Leary
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
PurposeSomatic molecular profiling of pediatric brain tumors aids with the diagnosis and treatment of patients with a variety of high- and low-grade central nervous system neoplasms. Here, we report follow-up targeted germline evaluation for patients
Externí odkaz:
https://doaj.org/article/8310c51029a946e99c35aa8a93b40535
Autor:
Miranda P.G. Zalusky, Jonas A. Gustafson, Stephanie C. Bohaczuk, Ben Mallory, Paxton Reed, Tara Wenger, Erika Beckman, Irene J. Chang, Cate R. Paschal, Jillian G. Buchan, Christina M. Lockwood, Mihai Puia-Dumitrescu, Daniel R. Garalde, Joseph Guillory, Androo J. Markham, Michael J. Bamshad, Evan E. Eichler, Andrew B. Stergachis, Danny E. Miller
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 101833- (2024)
Purpose: Rapid genetic testing in the critical care setting may guide diagnostic evaluation, direct therapies, and help families and care providers make informed decisions about goals of care. We tested whether a simplified DNA extraction and library
Externí odkaz:
https://doaj.org/article/6d44b504cf61496087437a8f47863416
Autor:
Ana A. Weil, Kyle G. Luiten, Amanda M. Casto, Julia C. Bennett, Jessica O’Hanlon, Peter D. Han, Luis S. Gamboa, Evan McDermot, Melissa Truong, Geoffrey S. Gottlieb, Zack Acker, Caitlin R. Wolf, Ariana Magedson, Eric J. Chow, Natalie K. Lo, Lincoln C. Pothan, Devon McDonald, Tessa C. Wright, Kathryn M. McCaffrey, Marlin D. Figgins, Janet A. Englund, Michael Boeckh, Christina M. Lockwood, Deborah A. Nickerson, Jay Shendure, Trevor Bedford, James P. Hughes, Lea M. Starita, Helen Y. Chu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
This study presents results from a SARS-CoV-2 genomic surveillance study at a university campus in which ~2,000 samples were sequenced over five months. The authors document the replacement of Delta with Omicron as the dominant variant, and describe
Externí odkaz:
https://doaj.org/article/92322f8983524d7dad8b3aee0ac192b1
Autor:
Bingcheng Jiang, Cameron Murray, Bonnie L. Cole, J. N. Mark Glover, Gordon K. Chan, Jean Deschenes, Rajam S. Mani, Sudip Subedi, John D. Nerva, Anthony C. Wang, Christina M. Lockwood, Heather C. Mefford, Sarah E. S. Leary, Jeffery G. Ojemann, Michael Weinfeld, Chibawanye I. Ene
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Polynucleotide Kinase-Phosphatase (PNKP) is a bifunctional enzyme that possesses both DNA 3′-phosphatase and DNA 5′-kinase activities, which are required for processing termini of single- and double-strand breaks generated by reactive ox
Externí odkaz:
https://doaj.org/article/691b06de37ce47d1a593a40ce1fec6f7
Autor:
Eric Venner, Donna Muzny, Joshua D. Smith, Kimberly Walker, Cynthia L. Neben, Christina M. Lockwood, Phillip E. Empey, Ginger A. Metcalf, Chris Kachulis, The All of Us Research Program Regulatory Working Group, Sana Mian, Anjene Musick, Heidi L. Rehm, Steven Harrison, Stacey Gabriel, Richard A. Gibbs, Deborah Nickerson, Alicia Y. Zhou, Kimberly Doheny, Bradley Ozenberger, Scott E. Topper, Niall J. Lennon
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract Background The All of Us Research Program (AoURP, “the program”) is an initiative, sponsored by the National Institutes of Health (NIH), that aims to enroll one million people (or more) across the USA. Through repeated engagement of part
Externí odkaz:
https://doaj.org/article/e910cd798cad40ff995d316fed013e1c
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 15 (2021)
Background Placental derived cell‐free DNA (cfDNA), widely utilized for prenatal screening, may serve as a biomarker for preeclampsia. To determine whether cfDNA parameters are altered in preeclampsia, we conducted a case‐control study using pros
Externí odkaz:
https://doaj.org/article/2378fb95f1ee4516ae73a450a915d26f
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 7, p 219 (2022)
Background: Pediatric brain tumors are the leading cause of cancer death in children and represent a variety of diseases and molecular subtypes. This study sought to evaluate a rapid immunohistochemistry testing panel to aid in therapy selection at t
Externí odkaz:
https://doaj.org/article/b890abde404e40aabc4449c505a06aaa
Autor:
Li Lei, Bradley A. Stohr, Stacey Berry, Christina M. Lockwood, Jessica L. Davis, Erin R. Rudzinski, Christian A. Kunder
Publikováno v:
Practical Laboratory Medicine, Vol 21, Iss , Pp e00164- (2020)
Objectives: To identify oncogenic driver mutations in congenital mesoblastic nephroma (CMN) cases lacking ETV6-NTRK3 fusion and discuss their diagnostic value. Design: The institutional pathology database was queried for cases with a morphologic diag
Externí odkaz:
https://doaj.org/article/5f0b58aa2adf416fa77fe42c06845580
Autor:
Ayako J. Kuo, Vera A. Paulson, Jennifer A. Hempelmann, Mallory Beightol, Sheena Todhunter, Brice G. Colbert, Stephen J. Salipante, Eric Q. Konnick, Colin C. Pritchard, Christina M. Lockwood
Publikováno v:
Practical Laboratory Medicine, Vol 19, Iss , Pp - (2020)
Objectives: The rapid discovery of clinically significant genetic variants has translated to next-generation sequencing assays becoming out-of-date by the time they are designed, validated, and implemented. UW-OncoPlex addresses this through the adop
Externí odkaz:
https://doaj.org/article/c9d2733df5de49c1ab6b4390e50bce81
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Genetic data are rapidly becoming part of tumor classification and are integral to prognosis and predicting response to therapy. Current molecular tumor profiling relies heavily on tissue resection or biopsy. Tissue profiling has several disadvantage
Externí odkaz:
https://doaj.org/article/ad5b8864be614db787cdbb559f68af3d