Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Christina M. Dersch"'
Autor:
Tamara Antonio, Steven R Childers, Richard B Rothman, Christina M Dersch, Christine King, Martin Kuehne, William G Bornmann, Amy J Eshleman, Aaron Janowsky, Eric R Simon, Maarten E A Reith, Kenneth Alper
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77262 (2013)
The iboga alkaloids are a class of small molecules defined structurally on the basis of a common ibogamine skeleton, some of which modify opioid withdrawal and drug self-administration in humans and preclinical models. These compounds may represent a
Externí odkaz:
https://doaj.org/article/15dd1576a36a4ceaa239a8d0e66074b4
Autor:
Richard B Rothman, Jean L Cadet, Christina M Dersch, Michael T McCoy, Elin Lehrmann, Kevin G Becker, Michael Bader, Natalia Alenina, Michael H Baumann
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17735 (2011)
The use of fenfluramines can increase the risk of developing pulmonary arterial hypertension (PAH) in humans, but the mechanisms responsible are unresolved. A recent study reported that female mice lacking the gene for tryptophan hydroxylase-1 (Tph1(
Externí odkaz:
https://doaj.org/article/b39313865104454697e06c4fa7fb3fa5
Publikováno v:
European Journal of Medicinal Chemistry. 92:531-539
Racemic N-substituted -1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols containing cis-4aaralkyl groups were explored as probes for opioid receptors. Specifically cis-4a-phenylpropyl, -phenylbutyl, and- phenylpentyl groups coupled with widely var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d837be85907cd0fa2babb8e9f3aa7d6
https://doi.org/10.1016/j.ejmech.2015.01.025
https://doi.org/10.1016/j.ejmech.2015.01.025
Autor:
Hwan Jung Lim, Richard B. Rothman, Arthur E. Jacobson, Christina M. Dersch, Jeffrey R. Deschamps, Kenner C. Rice
Publikováno v:
European Journal of Medicinal Chemistry. 67:335-343
The exploration of the effect of substituents at C7 and C8 of the 5-phenylmorphans on their affinity for opioid receptors was enabled by our recently introduced “one pot” diastereoselective synthesis that provided C7-oxo, hydroxy and alkyl substi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7094be3f35e3acf06d56fa41490c41
https://doi.org/10.1016/j.ejmech.2013.06.030
https://doi.org/10.1016/j.ejmech.2013.06.030
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:3298-3309
A series of N-methyl rac-cis-4a-aralkyl- and alkyl-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols have been prepared (2a–l) using a simple previously designed synthetic route, in order to find a ligand that would interact with bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0598460a3b0daf71d40c1eba6da3f1b7
https://doi.org/10.1016/j.bmc.2013.02.060
https://doi.org/10.1016/j.bmc.2013.02.060
Autor:
Bo Li, Paul E. FitzMorris, David J. Martin, Amy M. Deveau, Richard B. Rothman, Mario A. Ayestas, Christina M. Dersch, Ellicott J. Sally
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6801-6805
In an effort to better understand the conformational preferences that inform the biological activity of naltrexone and related naltrexol derivatives, a new synthesis of the restricted analog 3-OBn-6β,14-epoxymorphinan 4 is described. 4 was synthesiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba5e5f7280273f783a36fb901b80c9c
https://doi.org/10.1016/j.bmcl.2012.06.056
https://doi.org/10.1016/j.bmcl.2012.06.056
Autor:
Eduardo R. Butelman, Katherine M. Prevatt-Smith, Anthony Lozama, Richard B. Rothman, Victor W. Day, Tamara Vasiljevik, Thomas E. Prisinzano, Juan J. Araya, Christina M. Dersch, Mary Jeanne Kreek, Kimberly M. Lovell
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:3100-3110
Modification of the furan ring of salvinorin A ( 1 ), the main active component of Salvia divinorum , has resulted in novel neoclerodane diterpenes with opioid receptor affinity and activity. Conversion of the furan ring to an aldehyde at the C-12 po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268d03df42f360dc54b8415e21552512
https://doi.org/10.1016/j.bmc.2012.02.040
https://doi.org/10.1016/j.bmc.2012.02.040
Autor:
Jeffrey R. Deschamps, Yong Sok Lee, Malliga R. Iyer, Arthur E. Jacobson, Christina M. Dersch, Richard B. Rothman, Kenner C. Rice
Publikováno v:
European Journal of Medicinal Chemistry. 50:44-54
A simple three-step synthesis of 5-(3-hydroxyphenyl)-2-methyl-2-azabicyclo[3.3.1]nonan-4-ol (3a) was achieved using an osmium tetroxide mediated oxidation of the known intermediate 6. A pyrrolidine-ring variant of 3a (3-(7-(hydroxymethyl)-6-methyl-6-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90b146c7a01afde8c1ca9fd51cf2277
https://doi.org/10.1016/j.ejmech.2012.01.025
https://doi.org/10.1016/j.ejmech.2012.01.025
Autor:
Feng Li, Jason A. Deck, Arthur E. Jacobson, Jeffrey R. Deschamps, Kenner C. Rice, Kejun Cheng, Christina M. Dersch, Richard B. Rothman, John E. Folk, Muneaki Kurimura
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:4330-4337
N-Phenethyl-substituted ortho-a and para-a oxide-bridged phenylmorphans have been obtained through an improved synthesis and their binding affinity examined at the various opioid receptors. Although the N-phenethyl substituent showed much greater aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6651c4304b3c787d2961ed9a14e34620
https://doi.org/10.1016/j.bmc.2011.05.035
https://doi.org/10.1016/j.bmc.2011.05.035
Autor:
Justin T. Douglas, Michael J. Caspers, Richard B. Rothman, Christina M. Dersch, Anthony Lozama, Thomas E. Prisinzano, Christopher W. Cunningham
Publikováno v:
Journal of Natural Products. 74:718-726
As part of our continuing efforts toward more fully understanding the structure-activity relationships of the neoclerodane diterpene salvinorin A, we report the synthesis and biological characterization of unique cycloadducts through [4+2] Diels-Alde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865840a072a46ca5a4b2a5eca2638b5d
https://doi.org/10.1021/np1007872
https://doi.org/10.1021/np1007872