Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Christina M. Alfieri"'
Autor:
Christina M. Alfieri, Emma J Agnew, Sithara Raju Ponny, Farhan Zafar, Kyle W. Riggs, Katherine E. Yutzey, Nivedhitha Velayutham, Richard Baker
Publikováno v:
The FASEB Journal. 35
Publikováno v:
The Anatomical Record. 302:125-135
Epithelial-to-mesenchymal transition (EMT) enables stationary epithelial cells to exhibit migratory behavior and is the key step that initiates heart valve development. Recent studies suggest that EMT is reactivated in the pathogenesis of myxomatous
Autor:
Farhan Zafar, Emma J Agnew, Christina M. Alfieri, Kyle W. Riggs, Nivedhitha Velayutham, Katherine E. Yutzey, Sithara Raju Ponny, Richard S Baker
Publikováno v:
Circulation. 142
Background: Rodent cardiomyocytes (CM) undergo mitotic arrest and decline of mononucleated-diploid population post-birth, which are implicated in neonatal loss of heart regenerative potential. However, the dynamics of postnatal CM maturation are larg
Autor:
Emma J Agnew, Kyle W. Riggs, Sithara Raju Ponny, Katherine E. Yutzey, Christina M. Alfieri, R. Scott Baker, Farhan Zafar, Nivedhitha Velayutham
Publikováno v:
J Mol Cell Cardiol
AimsCardiomyocyte (CM) cell cycle arrest, decline of mononucleated-diploid CMs, sarcomeric maturation, and extracellular matrix remodeling are implicated in loss of cardiac regenerative potential in mice after birth. Recent studies show a 3-day neona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecf4e2e92f39a00087c18f0c3d64899
https://doi.org/10.1101/773101
https://doi.org/10.1101/773101
Autor:
Tarek Alsaied, Farhan Zafar, R. Scott Baker, Kyle W. Riggs, Sithara Raju Ponny, Katherine E. Yutzey, Victoria Moore, Emma J Agnew, Gabriela Matos Ortiz, Nivedhitha Velayutham, Aaron M. Gibson, Christina M. Alfieri
Studies in mice show a brief neonatal period of cardiac regeneration with minimal scar formation. Less is known about reparative mechanisms in large mammals. A transient cardiac injury approach (ischemia/reperfusion, IR) was used in weaned postnatal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c36330df10b86932b9c3e3426ee6c2d
https://doi.org/10.1101/773218
https://doi.org/10.1101/773218
Autor:
Christina M. Alfieri, Kyle W. Riggs, Katherine E. Yutzey, Emma J Agnew, Farhan Zafar, Nivedhitha Velayutham, Richard S Baker
Publikováno v:
Circulation Research. 125
Objectives: Cardiomyocyte (CM) cell cycle arrest and decline of mononucleated diploid CMs have been implicated in loss of regenerative potential in postnatal mouse hearts. Sarcomeric and extracellular matrix (ECM) maturation also occur concurrently i
Autor:
Gabriela Matos Ortiz, Emma J Agnew, Christina M. Alfieri, Sithara Raju Ponny, Nivedhitha Velayutham, Victoria Moore, Luis Hortells, Tarek Alsaied, Farhan Zafar, R. Scott Baker, Kyle W. Riggs, Katherine E. Yutzey, Aaron M. Gibson
Publikováno v:
Journal of Cardiovascular Development and Disease
Volume 7
Issue 1
Volume 7
Issue 1
Studies in mice show a brief neonatal period of cardiac regeneration with minimal scar formation, but less is known about reparative mechanisms in large mammals. A transient cardiac injury approach (ischemia/reperfusion, IR) was used in weaned postna
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34:2601-2608
Objective— The Wnt/β-catenin signaling pathway has been implicated in human heart valve disease and is required for early heart valve formation in mouse and zebrafish. However, the specific functions of Wnt/β-catenin signaling activity in heart v
Autor:
Katherine E. Yutzey, Elaine E. Wirrig-Schwendeman, Jonathan D. Cheek, Robert B. Hinton, Christina M. Alfieri, M. Victoria Gomez Stallons, Ming Fang
Publikováno v:
Etiology and Morphogenesis of Congenital Heart Disease ISBN: 9784431546276
The mature heart valves consist of stratified extracellular matrix (ECM) layers, and heart valve disease is characterized by ECM dysregulation and mineralization. There is increasing evidence that regulatory pathways that control heart valve developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0420483973b8311b184b63c8aee553c
https://doi.org/10.1007/978-4-431-54628-3_18
https://doi.org/10.1007/978-4-431-54628-3_18
Publikováno v:
Journal of Molecular and Cellular Cardiology. 52:689-700
Studies of human diseased aortic valves have demonstrated increased expression of genetic markers of valve progenitors and osteogenic differentiation associated with pathogenesis. Three potential mouse models of valve disease were examined for cellul