Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Christina M Pabelick"'
Autor:
Mark E Wylam, Venkatachalem Sathish, Sarah Kay VanOosten, Michelle Freeman, David Burkholder, Michael A Thompson, Christina M Pabelick, Y S Prakash
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128778 (2015)
Cigarette smoke contributes to or exacerbates airway diseases such as asthma and COPD, where airway hyperresponsiveness and airway smooth muscle (ASM) proliferation are key features. While factors such as inflammation contribute to asthma in part by
Externí odkaz:
https://doaj.org/article/ed5b69304ed7478db9372bfbd3b29287
Autor:
William Hartman, Martin Helan, Dan Smelter, Venkatachalem Sathish, Michael Thompson, Christina M Pabelick, Bruce Johnson, Y S Prakash
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0129489 (2015)
Hypoxia effects on pulmonary artery structure and function are key to diseases such as pulmonary hypertension. Recent studies suggest that growth factors called neurotrophins, particularly brain-derived neurotrophic factor (BDNF), can influence lung
Externí odkaz:
https://doaj.org/article/be0865b199aa4b80939929d706cbab9a
Autor:
Colleen M. Bartman, Lisa Nesbitt, Kenge K. Lee, Latifa Khalfaoui, Yun‐Hua Fang, Christina M. Pabelick, Y. S. Prakash
Publikováno v:
Physiological Reports, Vol 12, Iss 13, Pp n/a-n/a (2024)
Abstract Supplemental O2 (hyperoxia) is a critical intervention for premature infants (
Externí odkaz:
https://doaj.org/article/69b90bc72683470b87e4976f4d1a4f66
Autor:
Amard J Abcejo, Venkatachalem Sathish, Dan F Smelter, Bharathi Aravamudan, Michael A Thompson, William R Hartman, Christina M Pabelick, Y S Prakash
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e44343 (2012)
Neurotrophins (NTs), which play an integral role in neuronal development and function, have been found in non-neuronal tissue (including lung), but their role is still under investigation. Recent reports show that NTs such as brain-derived neurotroph
Externí odkaz:
https://doaj.org/article/7233ac1f2d704b47afad4a533070d0d8
Autor:
Venkatachalem Sathish, Philippe F Delmotte, Michael A Thompson, Christina M Pabelick, Gary C Sieck, Y S Prakash
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23662 (2011)
Enhanced airway contractility following inflammation by cytokines such as tumor necrosis factor alpha (TNFα) or interleukin-13 (IL-13) involves increased intracellular Ca(2+) ([Ca(2+)](i)) levels in airway smooth muscle (ASM). In ASM, plasma membran
Externí odkaz:
https://doaj.org/article/477dff990dfc489d9287f2f5f792ae75
Autor:
Mengning Zheng, Niyati A. Borkar, Yang Yao, Xianwei Ye, Elizabeth R. Vogel, Christina M. Pabelick, Y. S. Prakash
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Mechanosensitive channels (MS channels) are membrane proteins capable of responding to mechanical stress over a wide dynamic range of external mechanical stimuli. In recent years, it has been found that MS channels play an important role as “sentin
Externí odkaz:
https://doaj.org/article/8917cd4458fa42f1bad9cf99d092a12c
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Chronic airway diseases, such as wheezing and asthma, remain significant sources of morbidity and mortality in the pediatric population. This is especially true for preterm infants who are impacted both by immature pulmonary development as well as di
Externí odkaz:
https://doaj.org/article/73a57b38aa3e412d99e2b686b32fefcf
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/9fde63d172bc42f9a4e81777801bd90d
Autor:
Priyanka Banerjee, Premanand Balraj, Nilesh Sudhakar Ambhore, Sarah A. Wicher, Rodney D. Britt, Christina M. Pabelick, Y. S. Prakash, Venkatachalem Sathish
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Airway smooth muscle (ASM) is known for its role in asthma exacerbations characterized by acute bronchoconstriction and remodeling. The molecular mechanisms underlying multiple gene interactions regulating gene expression in asthma remain el
Externí odkaz:
https://doaj.org/article/8b34563885034ee5adaba98fb6aef59d
Autor:
Niyati A. Borkar, Nilesh Sudhakar Ambhore, Rama Satyanarayana Raju Kalidhindi, Christina M. Pabelick, Y.S. Prakash, Venkatachalem Sathish
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Sex and gender disparity in asthma is recognized and suggests a modulatory role for sex steroids, particularly estrogen. However, there is a dichotomous role for estrogen in airway remodeling, making it unclear whether sex hormones are protective or
Externí odkaz:
https://doaj.org/article/b370b7edd28042ea9617b99dd9c2c7bc