Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Christina M Homer"'
Autor:
Starlynn C Clarke, Phillip A Dumesic, Christina M Homer, Anthony J O'Donoghue, Florencia La Greca, Lenka Pallova, Pavel Majer, Hiten D Madhani, Charles S Craik
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006051 (2016)
The opportunistic fungal pathogen Cryptococcus neoformans is a major cause of mortality in immunocompromised individuals, resulting in more than 600,000 deaths per year. Many human fungal pathogens secrete peptidases that influence virulence, but in
Externí odkaz:
https://doaj.org/article/f632f8bdbdf246f2a8c203655a10e817
Publikováno v:
Genes & Development. 32:953-964
Packaging of pericentromeric DNA into heterochromatin is crucial for genome stability, development and health, yet its endogenous triggers remain poorly understood1. A defining feature of pericentromeric heterochromatin is histone H3 lysine 9 methyla
Autor:
Richard A. Festa, Dennis J. Thiele, James P. Noonan, Jun Yin, John R. Perfect, Sarela García-Santamarina, Chen-Hsin Yu, Hiten D. Madhani, Chen Ding, Aaron D. Smith, Christina M. Homer, Corinna Probst
Publikováno v:
Molecular Microbiology. 108:473-494
The ability of the human fungal pathogen Cryptococcus neoformans to adapt to variable copper (Cu) environments within the host is key for successful dissemination and colonization. During pulmonary infection, host alveolar macrophages compartmentaliz
Autor:
Erica Langnas, Albert F. Yen, Christina M. Homer, Antonio Gomez, Alexander Mohapatra, Carolyn M. Hendrickson
Publikováno v:
Critical care explorations, vol 1, iss 8
Critical Care Explorations
Critical Care Explorations
Objectives: We present a unique case of a broken fragment of a hypodermic needle breaking and embolizing to the heart. This needle subsequently penetrated the right ventricle and the patient developed hemopericardium which resulted in cardiac tampona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af78b01380242c36bfd09425d1652364
https://escholarship.org/uc/item/7w11v0p9
https://escholarship.org/uc/item/7w11v0p9
Autor:
Beate Schwer, Christina M. Homer, Jahan Yar Parsa, Robert J. Nichols, Hiten D. Madhani, Maki Inada, Jeffrey A. Pleiss, Ruby A. Benn, Reyal S. Hoxie, Stewart Shuman
Publikováno v:
Nucleic Acids Research
Eukaryotic gene expression requires that RNA Polymerase II (RNAP II) gain access to DNA in the context of chromatin. The C-terminal domain (CTD) of RNAP II recruits chromatin modifying enzymes to promoters, allowing for transcription initiation or re
Autor:
Colm J. Ryan, Kelly E. Nissen, Nevan J. Krogan, Michael Shales, Christina M. Homer, Christine Guthrie, Kristin L. Patrick
Publikováno v:
Genesdevelopment. 31(7)
Multiple lines of evidence implicate chromatin in the regulation of premessenger RNA (pre-mRNA) splicing. However, the influence of chromatin factors on cotranscriptional splice site usage remains unclear. Here we investigated the function of the hig
Autor:
Charles S. Craik, Anthony J. O’Donoghue, Pavel Majer, Christina M. Homer, Florencia La Greca, Hiten D. Madhani, Lenka Pallova, Starlynn Clarke, Phillip A. Dumesic
Publikováno v:
PLoS pathogens, vol 12, iss 12
Clarke, SC; Dumesic, PA; Homer, CM; O'Donoghue, AJ; La Greca, F; Pallova, L; et al.(2016). Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence. PLOS PATHOGENS, 12(12), e1006051. doi: 10.1371/journal.ppat.1006051. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0kq142xp
PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 12, p e1006051 (2016)
Clarke, SC; Dumesic, PA; Homer, CM; O'Donoghue, AJ; La Greca, F; Pallova, L; et al.(2016). Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence. PLOS PATHOGENS, 12(12), e1006051. doi: 10.1371/journal.ppat.1006051. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0kq142xp
PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 12, p e1006051 (2016)
The opportunistic fungal pathogen Cryptococcus neoformans is a major cause of mortality in immunocompromised individuals, resulting in more than 600,000 deaths per year. Many human fungal pathogens secrete peptidases that influence virulence, but in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf133550c52c31e4cb25d546cb8670b
https://escholarship.org/uc/item/0kq142xp
https://escholarship.org/uc/item/0kq142xp
Autor:
Veronica Pessino, Rajendra Upadhya, Charles S. Craik, Kirsten Nielsen, Jennifer K. Lodge, Starlynn Clarke, Hiten D. Madhani, John R. Yates, Christina A. Cuomo, Darin L. Wiesner, Dena L. Toffaletti, Sarah Petnic, Alexi I. Goranov, Jolene K. Diedrich, Christina M. Homer, James J. Moresco, John R. Perfect, Ippolito Caradonna, Diana K. Summers
Publikováno v:
Cell host & microbe, vol 19, iss 6
Quorum sensing (QS) is a bacterial communication mechanism in which secreted signaling molecules impact population function and gene expression. QS-like phenomena have been reported in eukaryotes with largely unknown contributing molecules, functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67db0a33945d96132890b9352432c0e0
https://europepmc.org/articles/PMC5186401/
https://europepmc.org/articles/PMC5186401/
Publikováno v:
Journal of Synchrotron Radiation. 18:338-345
It is important to consider radiation damage to crystals caused by data collection when solving structures and critical when determining protein function, which can often depend on very subtle structural characteristics. In this study the rate of dam
Autor:
Danica Galonić Fujimori, Lindsey R. Pack, John R. Yates, James J. Moresco, Scott M. Coyle, Erin K. Shanle, Brian D. Strahl, Christina M. Homer, Hiten D. Madhani, Phillip A. Dumesic
Summary We characterize the Polycomb system that assembles repressive subtelomeric domains of H3K27 methylation (H3K27me) in the yeast Cryptococcus neoformans . Purification of this PRC2-like protein complex reveals orthologs of animal PRC2 component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76321a698539c7e3fac3cd999308c0f9
https://europepmc.org/articles/PMC4303595/
https://europepmc.org/articles/PMC4303595/