Time trends in prevalence of p16 positivity and combined HPV/p16 positivity in a large cohort of Danish vulvar cancer patients

Autor: Christina Louise Rasmussen, Louise T. Thomsen, Louise Baandrup, Maria Benedicte Franzmann, Alexander K. Kjær, Lise Grupe Larsen, Else Mejlgaard Madsen, Nadia Margeth Villena Salinas, Doris Schledermann, Birgitte Hjelm Winberg, Dorthe Ørnskov, Marianne Waldstrøm, Susanne K. Kjær

Publikováno v: Rasmussen, C L, Thomsen, L T, Baandrup, L, Franzmann, M B, Kjær, A K, Larsen, L G, Madsen, E M, Salinas, N M V, Schledermann, D, Winberg, B H, Ørnskov, D, Waldstrøm, M & Kjær, S K 2023, ' Time trends in prevalence of p16 positivity and combined HPV/p16 positivity in a large cohort of Danish vulvar cancer patients ', International Journal of Cancer, vol. 152, no. 11, pp. 2424-2432 . https://doi.org/10.1002/ijc.34446

Vulvar cancer is rare, but causes substantial morbidity in affected patients. A subset of vulvar cancers is caused by high-risk human papillomavirus (hrHPV), which primarily exerts its oncogenic effect through upregulation of tumor suppressor protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546f573a428927b106e5edacd4432790
https://vbn.aau.dk/da/publications/ed0f47c3-37aa-4618-b392-87ac673ef04b

Changes in HPV prevalence in Danish women with vulvar cancer during 28 years – A nationwide study of >1300 cancer cases

Autor: Christina Louise Rasmussen, Louise T. Thomsen, Louise Baandrup, Maria Benedicte Franzmann, Lise Grupe Larsen, Else Mejlgaard Madsen, Nadia Villena Salinas, Doris Schledermann, Birgitte Hjelm Winberg, Dorthe Ørnskov, Marianne Waldstrøm, Susanne K. Kjaer

Publikováno v: Rasmussen, C L, Thomsen, L T, Baandrup, L, Franzmann, M B, Larsen, L G, Madsen, E M, Salinas, N V, Schledermann, D, Winberg, B H, Ørnskov, D, Waldstrøm, M & Kjaer, S K 2022, ' Changes in HPV prevalence in Danish women with vulvar cancer during 28 years – A nationwide study of >1300 cancer cases ', Gynecologic Oncology, vol. 166, no. 3, pp. 589-595 . https://doi.org/10.1016/j.ygyno.2022.06.014
Rasmussen, C L, Thomsen, L T, Baandrup, L, Franzmann, M B, Larsen, L G, Madsen, E M, Salinas, N V, Schledermann, D, Winberg, B H, Ørnskov, D, Waldstrøm, M & Kjaer, S K 2022, ' Changes in HPV prevalence in Danish women with vulvar cancer during 28 years-A nationwide study of >1300 cancer cases ', Gynecologic Oncology, vol. 166, no. 3, pp. 589-595 . https://doi.org/10.1016/j.ygyno.2022.06.014

Objective: A substantial proportion of vulvar cancers are caused by high-risk human papillomavirus (hrHPV), but hrHPV prevalence in vulvar cancer has mainly been investigated in smaller studies which did not evaluate time trends. Our aim was to asses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c2d02fa3a770f603f09d334009e0c7
https://pure.au.dk/portal/da/publications/changes-in-hpv-prevalence-in-danish-women-with-vulvar-cancer-during-28-years--a-nationwide-study-of-1300-cancer-cases(a1e7444f-3bdb-413c-a05f-7f36b8715e9d).html

The prognostic value of p16 and p53 expression for survival after vulvar cancer: A systematic review and meta-analysis

Autor: Christina Louise Rasmussen, Susanne K. Kjaer, Marie Frederiksen, Ditte Maria Bjerno Nielsen, Freja Lærke Sand

Publikováno v: Gynecologic Oncology. 152:208-217

The tumor suppressor proteins p16 and p53 have been suggested to have prognostic value in some human papillomavirus (HPV)-associated cancers, however, this has been less well established for vulvar cancer. The aim of this review and meta-analysis was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7087bdf586058ac7ec079d91abf4470c
https://doi.org/10.1016/j.ygyno.2018.10.015

Prognostic value of high-risk human papillomavirus DNA and p16INK4a immunohistochemistry in patients with anal cancer: An individual patient data meta-analysis

Autor: Joris Hautekiet, Stefan A. Koerber, Marc Arbyn, Svetlana Hetjens, Didier Meulendijks, Liliana Belgioia, Freija Verdoodt, Els Goetghebeur, Theresa Obermueller, Aivara Urbute, Elena Sophie Prigge, Ho-Young Yhim, Dries Reynders, Maria P. Busto, Christina Louise Rasmussen, Franz Rödel, Magnus von Knebel Doeberitz, Duncan C. Gilbert, Miriam Reuschenbach, Annemieke Cats, Susanne K. Kjaer, Sabine Mai, Christel Weiß

Background High-risk human papillomavirus (hrHPV) types represent the aetiological agents in a major proportion of anal squamous cell carcinomas (ASCC). Several studies have suggested a prognostic relevance of HPV-related markers, particularly hrHPV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7ac005b70f17fbe96dfa78cfd54016
http://hdl.handle.net/11567/1055538

Does HPV status influence survival after vulvar cancer?

Autor: Klaus Kaae Andersen, Christina Louise Rasmussen, Susanne K. Kjaer, Marie Frederiksen, Freja Lærke Sand

Publikováno v: International Journal of Cancer. 142:1158-1165

High-risk human papillomavirus (HPV) infection is essential in the carcinogenesis of a substantial part of anogenital and oropharyngeal cancers and has additionally been shown to be a possible predictive marker for survival, especially in oropharynge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4ee190d7464788b2a313e5f40c60e66
https://doi.org/10.1002/ijc.31139