Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Christina L. Pier"'
Autor:
Sabine Pellett, Marite Bradshaw, William H. Tepp, Christina L. Pier, Regina C. M. Whitemarsh, Chen Chen, Joseph T. Barbieri, Eric A. Johnson
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT Botulinum neurotoxin (BoNT) is the causative agent of botulism and a widely used pharmaceutical to treat a variety of neurological diseases. BoNTs are 150-kDa protein toxins organized into heavy chain (HC) and light chain (LC) domains linked
Externí odkaz:
https://doaj.org/article/aedc52e97f8748b7906c9ad8d9dcb24e
Autor:
Sabine Pellett, William H. Tepp, Marite Bradshaw, Suzanne R. Kalb, Janet K. Dykes, Guangyun Lin, Erin M. Nawrocki, Christina L. Pier, John R. Barr, Susan E. Maslanka, Eric A. Johnson
Publikováno v:
mSphere, Vol 1, Iss 1 (2016)
ABSTRACT Botulinum neurotoxins (BoNTs), produced by neurotoxigenic clostridial species, are the cause of the severe disease botulism in humans and animals. Early research on BoNTs has led to their classification into seven serotypes (serotypes A to G
Externí odkaz:
https://doaj.org/article/4e275d261f0a4a04804f12f1bbdf5d14
Autor:
Eric A. Johnson, Richard L. Whitman, Chan Lan Chun, Christina L. Pier, Guangyun Lin, Muruleedhara N. Byappanahalli, Chase I. Kahn, Michael J. Sadowsky, Julie R. Peller, Andrew J. Borchert
Publikováno v:
Science of The Total Environment. 511:523-529
The reemergence of avian botulism caused by Clostridium botulinum type E has been observed across the Great Lakes in recent years. Evidence suggests an association between the nuisance algae, Cladophora spp., and C. botulinum in nearshore areas of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f04328a37b802660f4b75790291f781
https://doi.org/10.1016/j.scitotenv.2014.12.080
https://doi.org/10.1016/j.scitotenv.2014.12.080
Autor:
Sabine Pellett, Janet K. Dykes, Christina L. Pier, William H. Tepp, Marite Bradshaw, Guangyun Lin, Eric A. Johnson, Erin M. Nawrocki, Suzanne R. Kalb, Susan E. Maslanka, John R. Barr
Publikováno v:
mSphere
mSphere, Vol 1, Iss 1 (2016)
mSphere, Vol 1, Iss 1 (2016)
Botulinum neurotoxins (BoNTs), produced by anaerobic bacteria, are the cause of the potentially deadly, neuroparalytic disease botulism. BoNTs have been classified into seven serotypes, serotypes A to G, based upon their selective neutralization by h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780d8d94fdc459a469227bbd52ac1d58
https://pubmed.ncbi.nlm.nih.gov/27303710
https://pubmed.ncbi.nlm.nih.gov/27303710
Autor:
William H. Tepp, Sabine Pellett, Su-Chun Zhang, Zhong-wei Du, Eric A. Johnson, Christina L. Pier
Publikováno v:
Biochemical and Biophysical Research Communications. 404:388-392
Botulinum neurotoxins (BoNTs), the most poisonous protein toxins known, represent a serious bioterrorism threat but are also used as a unique and important bio-pharmaceutical to treat an increasing myriad of neurological disorders. The only currently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf820ff2e961597d8de9a0b7e1d21f9
https://doi.org/10.1016/j.bbrc.2010.11.128
https://doi.org/10.1016/j.bbrc.2010.11.128
Autor:
Eric A. Johnson, Kim D. Janda, Guangyun Lin, Christina L. Pier, Sabine Pellett, Chen Chen, William H. Tepp, Joseph T. Barbieri
Publikováno v:
FEBS Letters. 585:199-206
Botulinum neurotoxins (BoNTs), the causative agent of human botulism, are the most potent naturally occurring toxins known. BoNT/A1, the most studied BoNT, is also used as an important biopharmaceutical. In this study, the biological activity of BoNT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc75c021c7a0ac587d12520bc0754585
https://doi.org/10.1016/j.febslet.2010.11.045
https://doi.org/10.1016/j.febslet.2010.11.045
Publikováno v:
Applied and Environmental Microbiology. 76:40-47
Clostridium botulinum subtype A2 possesses a botulinum neurotoxin type A (BoNT/A) gene cluster consisting of an orfX cluster containing open reading frames (ORFs) of unknown functions. To better understand the association between the BoNT/A2 complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06dcfcf7d9111b501811647ecc145957
https://doi.org/10.1128/aem.01882-09
https://doi.org/10.1128/aem.01882-09
Autor:
Christina L. Pier, Eric A. Johnson, Mark J. Jacobson, James S. Henkel, Joseph T. Barbieri, William H. Tepp
Publikováno v:
Biochemistry. 48:2522-2528
Botulinum toxins (BoNT) are zinc proteases (serotypes A-G) which cause flaccid paralysis through the cleavage of SNARE proteins within motor neurons. BoNT/A was originally organized into two subtypes, BoNT/A1 and BoNT/A2, which are approximately 95%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91dc6b1d6ce924888451bcfab72e8fe0
https://doi.org/10.1021/bi801686b
https://doi.org/10.1021/bi801686b
Autor:
William L. Murphy, Eric A. Johnson, Christina L. Pier, Jacob M. Scherf, James A. Thomson, Sabine Pellett, William H. Tepp, Richard Josephson, Michael P. Schwartz
Publikováno v:
Scientific Reports
Botulinum neurotoxin (BoNT) detection provides a useful model for validating cell-based neurotoxicity screening approaches, as sensitivity is dependent on functionally competent neurons and clear quantitative endpoints are available for correlating r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74d1827aaa6b719125eb9359e8571a8
Botulinum Neurotoxin type D (BoNT/D) causes periodic outbreaks of botulism in cattle and horses, but is rarely associated with human botulism. Previous studies have shown that humans responded poorly to peripheral injection of up to 10 U of BoNT/D. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b7845006d3733010ce8461e100c448
https://europepmc.org/articles/PMC4458207/
https://europepmc.org/articles/PMC4458207/
