Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Christina L. Parker"'
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Despite their exceptional potencies, the broad tropism of most commonly used lentivirus (LV) vectors limits their use for targeted gene delivery in vivo. We hypothesized that we could improve the specificity of LV targeting by coupling (i) r
Externí odkaz:
https://doaj.org/article/ec5128a80ad04306b61419331c297045
Autor:
Simone Hettmer, Anna C Schinzel, Daria Tchessalova, Michaela Schneider, Christina L Parker, Roderick T Bronson, Nigel GJ Richards, William C Hahn, Amy J Wagers
Publikováno v:
eLife, Vol 4 (2015)
Current therapies for sarcomas are often inadequate. This study sought to identify actionable gene targets by selective targeting of the molecular networks that support sarcoma cell proliferation. Silencing of asparagine synthetase (ASNS), an amidotr
Externí odkaz:
https://doaj.org/article/02c860c99dd149119671592902b66edd
Autor:
Alexander K. Nguyen, Daniel Wadsworth, Samuel K. Lai, Timothy M. Jacobs, Alison Schaefer, Jay M. Newby, Anting Wang, Christina L. Parker, Justin T. Huckaby
Publikováno v:
Angewandte Chemie. 131:5660-5664
Mucus represents a major barrier to sustained and targeted drug delivery to mucosal epithelium. Ideal drug carriers should not only rapidly diffuse across mucus, but also bind the epithelium. Unfortunately, ligand-conjugated particles often exhibit p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7653d59d1f13c9d9d04163206d569e
https://doi.org/10.1002/ange.201814665
https://doi.org/10.1002/ange.201814665
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
mBio, Vol 11, Iss 1, p e02990-19 (2020)
mBio
mBio, Vol 11, Iss 1, p e02990-19 (2020)
mBio
The goal of gene therapy is specific delivery and expression of therapeutic genes to target cells and tissues. Common lentivirus (LV) vectors are efficient gene delivery vehicles but offer little specificity. Here, we report an effective and versatil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481da69605bbc77a928cb73237daf2c3
https://journals.asm.org/doi/10.1128/mBio.02990-19
https://journals.asm.org/doi/10.1128/mBio.02990-19
Autor:
Morgan D. McSweeney, William C. Zamboni, Timothy M. Jacobs, Andrew T. Lucas, Samuel K. Lai, Daniel Wadsworth, Christina L. Parker
Publikováno v:
Nanomedicine
Pretargeting is an increasingly explored strategy to improve nanoparticle targeting, in which pretargeting molecules that bind both selected epitopes on target cells and nanocarriers are first administered, followed by the drug-loaded nanocarriers. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3896577279fea25bd793fa4d099490cd
https://pubmed.ncbi.nlm.nih.gov/31394261
https://pubmed.ncbi.nlm.nih.gov/31394261
Autor:
Christina L. Parker, Steven J. Gray, G Matsushima, Thomas J. McCown, Sara K. Powell, N Khan, Richard Jude Samulski
Publikováno v:
Gene Therapy. 23:807-814
No adeno-associated virus (AAV) capsid has been described in the literature to exhibit a primary oligodendrocyte tropism when a constitutive promoter drives gene expression, which is a significant barrier for efficient in vivo oligodendrocyte gene tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a959ce5f26dfb6ed776908ed6f210c
https://doi.org/10.1038/gt.2016.62
https://doi.org/10.1038/gt.2016.62
Publikováno v:
Acta biomaterialia. 63
Pretargeting represents a promising strategy to enhance delivery of nanoparticles. The strategy involves first introducing bispecific antibodies or fusion proteins (BFP) that can bind specific epitopes on target cells with one arm, and use the other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa72b0e877e6371b17f6d3cbdead08d
https://pubmed.ncbi.nlm.nih.gov/28870833
https://pubmed.ncbi.nlm.nih.gov/28870833
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 255
Tumor heterogeneity, which describes the genetically and phenotypically distinct subpopulations of tumor cells present within the same tumor or patient, presents a major challenge to targeted delivery of diagnostic and/or therapeutic agents. An ideal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac9f08b92d9cdf408dd0518cf3cffdf
https://pubmed.ncbi.nlm.nih.gov/28363519
https://pubmed.ncbi.nlm.nih.gov/28363519
Tumors are frequently characterized by genomically and phenotypically distinct cancer cell subpopulations within the same tumor or between tumor lesions, a phenomenon termed tumor heterogeneity. These diverse cancer cell populations pose a major chal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b651c7720ce19ae9eddcd56af2adbb10
Autor:
James E. Bear, William C. Zamboni, Stephen W. Jones, Qi Yang, Christina L. Parker, Samuel K. Lai
Publikováno v:
Molecular pharmaceutics. 11(4)
Coating nanoparticles with polyethylene glycol (PEG), which reduces particle uptake and clearance by immune cells, is routinely used to extend the circulation times of nanoparticle therapeutics. Nevertheless, due to technical hurdles in quantifying t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4771fbf87c3339ec0f283cd79a70dc75
https://pubmed.ncbi.nlm.nih.gov/24521246
https://pubmed.ncbi.nlm.nih.gov/24521246