Výsledky vyhledávání - "Christina L. McHenry"

Macrophage/epithelial cell CCL2 contributes to rhinovirus-induced hyperresponsiveness and inflammation in a mouse model of allergic airways disease

Autor: Christina L. McHenry, Emily R. Bowman, J. Kelley Bentley, Marc B. Hershenson, Jun Young Hong, Toby C. Lewis, Yutein Chung, Dina Schneider, Deepti R. Nagarkar, Adam M. Goldsmith

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 304:L162-L169

Human rhinovirus (HRV) infections lead to exacerbations of lower airways disease in asthmatic patients but not in healthy individuals. However, underlying mechanisms remain to be completely elucidated. We hypothesized that the Th2-driven allergic env

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fa1e9a7ec617f6529947637d1f1095
https://doi.org/10.1152/ajplung.00182.2012

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Nasal cytokine responses to natural colds in asthmatic children

Autor: Thomas G. Robins, Layla S. Mohammad, Marc B. Hershenson, Terence A. Joiner, Emily R. Nguyen, Toby C. Lewis, Graciela Mentz, Xiaodan Ren, Adam M. Goldsmith, Bhramar Mukherjee, Tiffany A. Henderson, Christina L. McHenry, David T. Burke, Ashley R. Carpenter, Ixsy A. Ramirez, Mark A. Burns

Publikováno v: Clinical & Experimental Allergy

SummaryBackground The mechanisms by which viruses induce asthma exacerbations are not well understood. Objective We characterized fluctuations in nasal aspirate cytokines during naturally occurring respiratory viral infections in children with asthma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3963f5cae834188d9b6c55a76e4aad41

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Targeted Disruption of the Murine Retinal Dehydrogenase Gene Rdh12 Does Not Limit Visual Cycle Function

Autor: Michaela Schweizer, Jana Schroth, Kecia L. Feathers, Sergej Skosyrski, Debra A. Thompson, Ingo Kurth, J. D. Chrispell, Andreas Gal, Christian A. Hübner, Klaus Rüther, Christina L. McHenry

Publikováno v: Molecular and Cellular Biology. 27:1370-1379

RDH12 codes for a member of the family of short-chain alcohol dehydrogenases/reductases proposed to function in the visual cycle that supplies the chromophore 11-cis retinal to photoreceptor cells. Mutations in RDH12 cause severe and progressive chil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a248067c2a3b75d5a5d8d4edce42356
https://doi.org/10.1128/mcb.01486-06

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Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy

Autor: Bernd Wissinger, Christian A. Hübner, Anita R. Nair, Christina L. McHenry, Peter Nürnberg, Andreas R. Janecke, Debra A. Thompson, Christian Becker, Eduard Schmid, John R. Heckenlively, Franz Rüschendorf, Andreas Gal, Gerd Utermann

Publikováno v: Nature Genetics. 36:850-854

We identified three consanguineous Austrian kindreds with 15 members affected by autosomal recessive childhood-onset severe retinal dystrophy, a genetically heterogeneous group of disorders characterized by degeneration of the photoreceptor cells. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3754a39196bf3a04cbb054373afe5c86
https://doi.org/10.1038/ng1394

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MERTK Arginine-844-Cysteine in a Patient with Severe Rod-Cone Dystrophy: Loss of Mutant Protein Function in Transfected Cells

Autor: Christina L. McHenry, Andreas Gal, Yuhui Liu, Anita R. Nair, Wei Feng, Debra A. Thompson, Xiaoling Ding, Kecia L. Feathers, Paul A. Sieving, Douglas Vollrath

Publikováno v: Investigative Ophthalmology & Visual Science. 45:1456-1463

PURPOSE. Mutations in the MERTK gene are responsible for retinal degeneration in the Royal College of Surgeons (RCS) rat and are a cause of human autosomal recessive retinitis pigmentosa (RP). This study reports the identification and functional anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1dd535a293cae310c837e88ebe06879
https://doi.org/10.1167/iovs.03-0909

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Retinal Dystrophy Due to Paternal Isodisomy for Chromosome 1 or Chromosome 2, with Homoallelism for Mutations in RPE65 or MERTK, Respectively

Autor: Samuel G. Jacobson, Christina L. McHenry, Andreas Gal, Julia E. Richards, Yun Li, Eberhard Schwinger, Debra A. Thompson, Mohammad Othman, Douglas Vollrath

Publikováno v: The American Journal of Human Genetics. 70(1):224-229

Uniparental disomy (UPD) is a rare condition in which a diploid offspring carries a chromosomal pair from a single parent. We now report the first two cases of UPD resulting in retinal degeneration. We identified an apparently homozygous loss-of-func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a582cefd8082e4866a53bf6772e8bf5

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Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages

Autor: Marisa J. Linn, Christina L. McHenry, Emily R. Bowman, Umadevi S. Sajjan, Marc B. Hershenson, J. Kelley Bentley, Ying Zhao, Jee Shim, Babina Gosangi, Qiong Wang, Deepti R. Nagarkar, Dina Schneider, Wan C. Tsai, Nicholas W. Lukacs

Human rhinovirus is responsible for the majority of virus-induced asthma exacerbations. To determine the immunologic mechanisms underlying rhinovirus (RV)-induced asthma exacerbations, we combined mouse models of allergic airways disease and human rh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8541f0f4ae743c93247abea638626a1
https://europepmc.org/articles/PMC3208235/

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