Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Christina L. Inman"'
Autor:
Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I. Melos, Tamar Pirtskhalava, Christina L. Inman, Collin McGuckian, Erin A. Wade, Jonathon I. Kato, Diego Grassi, Mark Wentworth, Christin E. Burd, Edgar A. Arriaga, Warren L. Ladiges, Tamara Tchkonia, James L. Kirkland, Paul D. Robbins, Laura J. Niedernhofer
Publikováno v:
EBioMedicine, Vol 36, Iss , Pp 18-28 (2018)
Background: Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmac
Externí odkaz:
https://doaj.org/article/02bd6a51774a495f90e8c345736d54df
Autor:
Lichao Wang, Binsheng Wang, Nathan S. Gasek, Yueying Zhou, Rachel L. Cohn, Dominique E. Martin, Wulin Zuo, William F. Flynn, Chun Guo, Evan R. Jellison, Taewan Kim, Larissa G.P. Langhi Prata, Allyson K. Palmer, Ming Li, Christina L. Inman, Lauren S. Barber, Iman M.A. Al-Naggar, Yanjiao Zhou, Wenqiang Du, null Kshitiz, George A. Kuchel, Alexander Meves, Tamar Tchkonia, James L. Kirkland, Paul Robson, Ming Xu
Publikováno v:
Cell Metab
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2 diabetes. Limited mechanism-based strategies exist to alleviate insulin resistance. Here, using single-cell transcriptomics, we iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1d77c97bb9b099109e3f03b8f5948f
https://europepmc.org/articles/PMC8832725/
https://europepmc.org/articles/PMC8832725/
Autor:
Utkarsh Tripathi, Mark Pierson, Paul D. Robbins, Nino Giorgadze, James L. Kirkland, David B. Allison, Tamara Tchkonia, Stephen C. Jameson, Sara E. Hamilton, Larissa G.P. Langhi Prata, Christina L. Inman, Stephanie H. Cholensky, Lei Zhang, Elizabeth J. Atkinson, Ming Li, Yi Zhu, Christina D. Camell, Jair Machado Espindola-Netto, Laura J. Niedernhofer, Tamar Pirtskhalava, Matthew A. Huggins, Alexander Meves, Matthew J. Yousefzadeh, Sundeep Khosla, Keisuke Ejima, Sergio E. Chiarella, Y. S. Prakash, M. Gerard O'Sullivan, Ryan D. O’Kelly, Nathan K. LeBrasseur, Timothy W. Carlson, Pengcheng Xun, Kurt O. Johnson, Ailing Xue
Publikováno v:
Science (New York, N.Y.)
INTRODUCTION: The COVID-19 pandemic revealed enhanced vulnerability of the elderly and chronically ill to adverse outcomes upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Senescence is a cell fate elicited by cellular str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22535dd9b9d0ac2c8ba2c2e3ee8167ab
http://europepmc.org/articles/PMC8607935
http://europepmc.org/articles/PMC8607935
Autor:
Yi Zhu, Larissa G.P. Langhi Prata, Erin O. Wissler Gerdes, Jair Machado Espindola Netto, Tamar Pirtskhalava, Nino Giorgadze, Utkarsh Tripathi, Christina L. Inman, Kurt O. Johnson, Ailing Xue, Allyson K. Palmer, Tingjun Chen, Kalli Schaefer, Jamie N. Justice, Anoop M. Nambiar, Nicolas Musi, Stephen B. Kritchevsky, Jun Chen, Sundeep Khosla, Diana Jurk, Marissa J. Schafer, Tamar Tchkonia, James L. Kirkland
Publikováno v:
eBioMedicine. 77:103912
α-Klotho is a geroprotective protein that can attenuate or alleviate deleterious changes with ageing and disease. Declines in α-Klotho play a role in the pathophysiology of multiple diseases and age-related phenotypes. Pre-clinical evidence suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1af958b293b82a37aa66fd09eda61cf
https://doi.org/10.1016/j.ebiom.2022.103912
https://doi.org/10.1016/j.ebiom.2022.103912
Autor:
Yueying Zhou, Zukai Liu, Lichao Wang, James L. Kirkland, Chun Guo, David W. Rowe, Ming Xu, Paul Robson, George A. Kuchel, Vicky Ping Chen, Binsheng Wang, Tamar Tchkonia, Christina L. Inman
Publikováno v:
Aging Cell
Adipose‐derived mesenchymal stem cell (ADSC)‐based regenerative therapies have shown potential for use in many chronic diseases. Aging diminishes stem cell regenerative potential, yet it is unknown whether stem cells from aged donors cause advers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5098233264c578f35fa9fd05624c540
http://europepmc.org/articles/PMC7059132
http://europepmc.org/articles/PMC7059132
Autor:
Christina L. Inman, Jonathon I. Kato, Yi Zhu, Collin A. McGuckian, Tamara Tchkonia, Kendra I. Melos, Diego Grassi, Tamar Pirtskhalava, Mark A. Wentworth, Paul D. Robbins, James L. Kirkland, Yuan Yuan Ling, Ming Xu, Edgar A. Arriaga, Laura J. Niedernhofer, Warren Ladiges, Matthew J. Yousefzadeh, Luise A. Angelini, Erin A. Wade, Christin E. Burd, Sara J. McGowan, Heike Fuhrmann-Stroissnigg
Publikováno v:
EBioMedicine
Background Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7947fab5e0881cf576a4d872fec951bc
https://doi.org/10.1016/j.ebiom.2018.09.015
https://doi.org/10.1016/j.ebiom.2018.09.015
Autor:
Bettina M. Weigand, Christine M Hachfeld, Ming Xu, Joshua N. Farr, Xiaonan Hou, Vesna D. Garovic, Jennifer L Onken, Larissa G.P. Langhi, Tamar Pirtskhalava, Hajrunisa Cubro, Ravinder J. Singh, S. John Weroha, Megan M. Weivoda, Mikolaj Ogrodnik, Kurt O. Johnson, Keisuke Ejima, Gene B. Hubbard, Laura J. Niedernhofer, Grace C Verzosa, Diana Jurk, James L. Kirkland, Paul D. Robbins, Moritz Weigl, Christina L. Inman, Jordan D. Miller, Daniel G. Fraser, David B. Allison, Nino Giorgadze, Sundeep Khosla, Yuji Ikeno, Allyson K. Palmer, Tamara Tchkonia, Nathan K. LeBrasseur
Publikováno v:
Nature medicine
Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these consequences of aging, but whether senescence can directly drive a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02db7172651264fd5240a5fe961df9ae
https://pubmed.ncbi.nlm.nih.gov/30292430
https://pubmed.ncbi.nlm.nih.gov/30292430