Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Christina L. Hirota"'
Publikováno v:
Mediators of Inflammation, Vol 2012 (2012)
TNF-α activates multiple mitogen-activated protein kinase (MAPK) cascades in intestinal epithelial cells (IECs) leading to the secretion of interleukin 8 (IL-8), a neutrophil chemoattractant and an angiogenic factor with tumor promoting properties.
Externí odkaz:
https://doaj.org/article/ff1407a1833f4388a44786d93b33a9ef
Autor:
Fernando A. Vicentini, Thomas K. H. Chang, Grace Marie Hudson, Alexandra D. Zamponi, Simon A. Hirota, Laurie Alston, Christina L. Hirota, Kevin P. Rioux, Kyle L. Flannigan, Subrata Ghosh, Sridhar Mani, Sarah L. Erickson, Christophe Altier
Publikováno v:
British Journal of Pharmacology. 174:1857-1871
Background and Purpose The pathogenesis of the inflammatory bowel diseases (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), involves aberrant interactions between a genetically susceptible individual, their microbiota and environme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d911f44bb9b33639a68797c9e407da6a
https://doi.org/10.1111/bph.13787
https://doi.org/10.1111/bph.13787
Autor:
Subrata Ghosh, Xinyang Gui, Aito Ueno, Marietta Iacucci, Tie Wang, Michael R. Tom, Gilaad G. Kaplan, Joanne Luider, Christina L. Hirota, Miriam Fort Gasia, Humberto Jijon, Paul L. Beck, Jiaming Qian, Remo Panaccione, Mailin Deane, Herman W. Barkema, Ronald Chan, Ji Li
Publikováno v:
Inflammatory Bowel Diseases. 22:1779-1792
Background Distinction between 2 forms of inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn's disease (CD), can be challenging. Aberrant mucosal immunity suggests that CD is a T helper type 1 cell (Th1)-driven disease, whereas UC as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348cdfbc82a0977040e1faa409e373a6
https://doi.org/10.1097/mib.0000000000000811
https://doi.org/10.1097/mib.0000000000000811
Publikováno v:
Journal of Crohn's and Colitis. 11:92-104
Background: The simplistically and ambiguously termed ‘fibrostenosis’ of bowel is a hallmark of severe Crohn’s disease [CD] and a major contributor to medical treatment failure. Non-invasive imaging assessment and novel medical therapy targetin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeaa3738c0967a43081b1ad6af16f661
https://doi.org/10.1093/ecco-jcc/jjw126
https://doi.org/10.1093/ecco-jcc/jjw126
Autor:
Christina L. Hirota, Michael A. Peplowski, Wallace K. MacNaughton, Rithwik Ramachandran, Morley D. Hollenberg, Koichiro Mihara, Vadim Iablokov
Publikováno v:
Physiology and Pharmacology Publications
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Mucosal biopsies from inflamed colon of inflammatory bowel disease patients exhibit elevated epithelial apoptosis compared with those from healthy individuals, disrupting mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7a559767f576dddf58c7e7e15712a7
https://doi.org/10.1074/jbc.m114.610485
https://doi.org/10.1074/jbc.m114.610485
Autor:
Christina L. Hirota, France Moreau, Vadim Iablokov, Michael Dicay, Bernard Renaux, Morley D. Hollenberg, Wallace K. MacNaughton
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 303:G111-G119
Proteinase-activated receptor (PAR)2, a G protein-coupled receptor activated by serine proteinases, has been implicated in both intestinal inflammation and epithelial proliferation. Cyclooxygenase (COX)-2 is overexpressed in the gut during inflammati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601bc1e1675562a00a7725e4d5a69212
https://doi.org/10.1152/ajpgi.00358.2011
https://doi.org/10.1152/ajpgi.00358.2011
Autor:
Derek M. McKay, Christina L. Hirota
Publikováno v:
British Journal of Pharmacology. 156:1085-1097
Background and purpose: Epithelial surface hydration is critical for proper gut function. However, colonic tissues from individuals with inflammatory bowel disease or animals with colitis are hyporesponsive to Cl- secretagogues. The Cl- secretory res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d691291967a9eddcd1eb4dc146148cd6
https://doi.org/10.1111/j.1476-5381.2009.00122.x
https://doi.org/10.1111/j.1476-5381.2009.00122.x
Autor:
Raza S. Zaheer, Christina L. Hirota, Natalie Ronaghan, Michael Dicay, Michael A. Peplowski, Colin A. Carati, Wallace K. MacNaughton
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118713 (2015)
PLoS ONE
PLoS ONE
Inflammatory bowel diseases are associated with dysregulated electrolyte and water transport and resultant diarrhea. Aquaporins are transmembrane proteins that function as water channels in intestinal epithelial cells. We investigated the effect of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095a5ed1f54cc1e4980dfc2cce0f3611
http://europepmc.org/articles/PMC4405000?pdf=render
http://europepmc.org/articles/PMC4405000?pdf=render
Autor:
Derek M. McKay, Christina L. Hirota
Publikováno v:
British Journal of Pharmacology. 149:463-479
Acetylcholine (ACh) is critical in controlling epithelial ion transport and hence water movements for gut hydration. Here we review the mechanism of cholinergic control of epithelial ion transport across the mammalian intestine. The cholinergic nervo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a582aa9952cb50b935fd50b04f7d37c
https://doi.org/10.1038/sj.bjp.0706889
https://doi.org/10.1038/sj.bjp.0706889
Autor:
Miriam Fort Gasia, Mailin Deane, Paul L. Beck, Ji Li, Marietta Iacucci, Xianyong Gui, Aito Ueno, Subrata Ghosh, Christina L. Hirota
Publikováno v:
Gastroenterology. 150:S419-S420
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b58a1c0698a47a8df70c76be90deb03
https://doi.org/10.1016/s0016-5085(16)31457-3
https://doi.org/10.1016/s0016-5085(16)31457-3