Výsledky vyhledávání - "Christina L Rotoloni"

Akademický článek

Prognostic value and targeted inhibition of survivin expression in esophageal adenocarcinoma and cancer-adjacent squamous epithelium.

Autor: Usha Malhotra, Ali H Zaidi, Juliann E Kosovec, Pashtoon M Kasi, Yoshihiro Komatsu, Christina L Rotoloni, Jon M Davison, Clint R, Irvin, Toshitaka Hoppo, Katie S Nason, Lori A Kelly, Michael K Gibson, Blair A Jobe

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e78343 (2013)

Survivin is an inhibitor of apoptosis and its over expression is associated with poor prognosis in several malignancies. While several studies have analyzed survivin expression in esophageal squamous cell carcinoma, few have focused on esophageal ade

Externí odkaz: https://doaj.org/article/2634f23a09ec41609999ef820ae54b54

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Smoothened Inhibition Leads to Decreased Proliferation and Induces Apoptosis in Esophageal Adenocarcinoma Cells

Autor: Haris Zahoor, Usha Malhotra, Blair A. Jobe, Toshitaka Hoppo, Rory Makielski, Lori A. Kelly, Christina L. Rotoloni, Juliann E. Kosovec, Astha Bhatt, Yoshihiro Komatsu, Ali H. Zaidi

Publikováno v: Cancer Investigation. 31:480-489

The Hedgehog (Hh) pathway is known to be active in Barrett's carcinogenesis. Therefore, we evaluated the efficacy and underlying mechanisms of inhibition of cancer cell growth by the smoothened (Smo) antagonist BMS-833923 in esophageal adenocarcinoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9aa96f6d2504ca77939267d83d997f1
https://doi.org/10.3109/07357907.2013.820317

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Prevention of Barrett Esophagus and Esophageal Adenocarcinoma by Smoothened Inhibitor in a Rat Model of Gastroesophageal Reflux Disease

Autor: Jon M. Davison, Blair A. Jobe, Astha Bhatt, Bruce Hough, Usha Malhotra, Alejandro F. Sanz, Ali H. Zaidi, Juliann E. Kosovec, Christina L. Rotoloni, Tyler Foxwell, Toshitaka Hoppo, Michael K. Gibson, Yoshihiro Komatsu

Publikováno v: Annals of Surgery. 258:82-88

BACKGROUND Activated hedgehog (Hh) pathway is associated with development of both Barrett esophagus (BE) and esophageal adenocarcinoma (EAC). We hypothesize that blockade of the Hh pathway with smoothened (Smo) inhibitor can prevent the development o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07c1af9ee218be52368e5377d2150f06
https://doi.org/10.1097/sla.0b013e318270500d

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Preclinical Study of AUY922, a Novel Hsp90 Inhibitor, in the Treatment of Esophageal Adenocarcinoma

Autor: Christina DiCarlo, Jan F. Silverman, Christina L. Rotoloni, Juliann E. Kosovec, Daisuke Matsui, Robert W Biederman, Elena L Kolano, Ali H. Zaidi, Gene Grant Finley, Natalie H. Boyd, Yoshihiro Komatsu, Rodney J. Landreneau, Christopher Vytlacil, Blair A. Jobe, Lori A. Kelly, Ashten N. Omstead

Publikováno v: Annals of surgery. 264(2)

To assess the efficacy of heat-shock protein 90 (Hsp90) inhibitor, NVP-AUY922-AG (AUY922), in the treatment of esophageal adenocarcinoma (EAC) in vitro and in vivo.EAC is a leading cause of cancer death, and current treatment options are limited. Hsp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156cef84aa0cc535ead024470a3a55ce
https://pubmed.ncbi.nlm.nih.gov/26445473

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Hypopharyngeal pepsin and Sep70 as diagnostic markers of laryngopharyngeal reflux: preliminary study

Autor: Toshitaka Hoppo, Lori A. Kelly, Amina Waheed, Blair A. Jobe, Yoshihiro Komatsu, Christina L. Rotoloni, Ali H. Zaidi, Emily J. Lloyd, Juliann E. Kosovec

Publikováno v: Surgical endoscopy. 29(5)

The management of laryngopharyngeal reflux (LPR) has been challenging. Hypopharyngeal multichannel intraluminal impedance (HMII) has shown to increase the sensitivity in diagnosing LPR. The objective of this study is to investigate the potential use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534476683c6282f50dbb143f18f8ad64
https://pubmed.ncbi.nlm.nih.gov/25159637

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Prognostic Value and Targeted Inhibition of Survivin Expression in Esophageal Adenocarcinoma and Cancer-Adjacent Squamous Epithelium

Autor: Jon M. Davison, Ali H. Zaidi, Pashtoon Murtaza Kasi, Christina L. Rotoloni, Yoshihiro Komatsu, Toshitaka Hoppo, Juliann E. Kosovec, Usha Malhotra, Katie S. Nason, Michael K. Gibson, Blair A. Jobe, Clint R, Irvin, Lori A. Kelly

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 11, p e78343 (2013)

Background: Survivin is an inhibitor of apoptosis and its over expression is associated with poor prognosis in several malignancies. While several studies have analyzed survivin expression in esophageal squamous cell carcinoma, few have focused on es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18889f4d1f1695c823dac1d4bbec90e
http://europepmc.org/articles/PMC3817247

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Abstract B05: MRI provides a more reliable method of esophageal tumor detection than endoscopy in a rat model

Autor: Yoshihiro Komatsu, Christina L. Rotoloni, Blair A. Jobe, Ali H. Zaidi, Juliann E. Kosovec, Diane V Thompson

Publikováno v: Molecular Cancer Research. 12:B05-B05

Background: The surgical rat model of end-to-side esophagojejunal anastomosis has proven utility in terms of its ability to replicate Barrett's carcinogenesis by inducing gastroduodenoesophageal reflux (GDER). Previously, visual endoscopic analysis h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11f905979c60a15df5686aacccbbac8b
https://doi.org/10.1158/1557-3125.modorg-b05

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Demonstrating preclinical efficacy of AUY922, a novel Hsp90 inhibitor, alone and in combination with standard chemotherapy or radiation in esophageal adenocarcinoma

Autor: Blair A. Jobe, Christina L. Rotoloni, Lori A. Kelly, Toshitaka Hoppo, Amina Waheed, Yoshihiro Komastu, Ali H. Zaidi, Juliann E. Kosovec, Daisuke Matsui

Publikováno v: Journal of Clinical Oncology. 32:e13506-e13506

e13506 Background: Several novel target agents, including heat shock protein 90 (Hsp90) inhibitor, AUY922, are being explored as treatment options for esophageal adenocarcinoma (EAC). Hsp90 is a ch...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cb76a61d86ba3a6b0a07fe01744fb81
https://doi.org/10.1200/jco.2014.32.15_suppl.e13506

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Abstract A48: Enhanced efficacy of cisplatin and 5-fluorouracil combination with AUY-922 in esophageal adenocarcinoma cells

Autor: Katherine Nega, Lori A. Kelly, Pashtoon Murtaza Kasi, Jaclyn M. LaRosa, Blair A. Jobe, Juliann E. Kosovec, Christina L. Rotoloni, Michael J. Porter, Yoshihiro Komastu, Toshitaka Hoppo, Emily Wolfson, Ali H. Zaidi

Publikováno v: Cancer Research. 73:A48-A48

Background: Esophageal Adenocarcinoma (EAC) continues to rise in incidence, with prognosis remaining poor despite advances in multimodality therapy. Several novel target agents are now being explored as an option for treating EAC. One potential targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28fae079b2966fdfc68b0021e0425bb5
https://doi.org/10.1158/1538-7445.fbcr13-a48

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