Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Christina L O'Neill"'
Autor:
Varun Pathak, Nupur Madhur Pathak, Christina L O’Neill, Jasenka Guduric-Fuchs, Reinhold J Medina
Publikováno v:
Clinical Medicine Insights: Endocrinology and Diabetes, Vol 12 (2019)
Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing β cells located in the endocrine pancreas in areas known as islets of Langerhans. The current standard-of-care for T1D is exogenous insulin replacement therapy. Recent de
Externí odkaz:
https://doaj.org/article/dfcc406d11504b7d9f60cb7a852e179b
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2584 (2008)
BackgroundCurrent guidelines encourage the use of statins to reduce the risk of cardiovascular disease in diabetic patients; however the impact of these drugs on diabetic retinopathy is not well defined. Moreover, pleiotropic effects of statins on th
Externí odkaz:
https://doaj.org/article/a2ff1159eaff41ea86bf0e760e742072
Autor:
Joana Mendes Lopes de Melo, James Bojdo, Rachel H. Church, Stuart McKeown, Christina L. O'Neill, Sarah Chambers, Kiran J McLoughlin, Reinhold J. Medina, Varun Pathak, Edoardo Pedrini, Alan W. Stitt, Jasenka Guduric-Fuchs, Judith Lechner
Publikováno v:
Guduric-Fuchs, J, Pedrini, E, Lechner, J, Chambers, S E J, O'Neill, C L, Mendes Lopes de Melo, J, Pathak, V, Church, R H, McKeown, S, Bojdo, J, McLoughlin, K J, Stitt, A W & Medina, R J 2021, ' miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia ', Molecular Therapy: Nucleic Acids, vol. 23, pp. 968-981 . https://doi.org/10.1016/j.omtn.2021.01.015
Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 968-981 (2021)
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 968-981 (2021)
Molecular Therapy. Nucleic Acids
Hypoxia modulates reparative angiogenesis, which is a tightly regulated pathophysiological process. MicroRNAs (miRNAs) are important regulators of gene expression in hypoxia and angiogenesis. However, we do not yet have a clear understanding of how h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd70672d5a2380ff60fcd059f57d4514
https://pure.qub.ac.uk/en/publications/mir130a-activates-the-vegfr2stat3hif1-axis-to-potentiate-the-vasoregenerative-capacity-of-endothelial-colonyforming-cells-in-hypoxia(1c0a5891-1d1d-4bbf-b019-8ce18108fc43).html
https://pure.qub.ac.uk/en/publications/mir130a-activates-the-vegfr2stat3hif1-axis-to-potentiate-the-vasoregenerative-capacity-of-endothelial-colonyforming-cells-in-hypoxia(1c0a5891-1d1d-4bbf-b019-8ce18108fc43).html
Publikováno v:
J Biol Chem
Dutton, L R, O'Neill, C L, Medina, R J & Brazil, D P 2019, ' No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cells ', The Journal of Biological Chemistry, vol. 294, no. 48, pp. 18041-18045 . https://doi.org/10.1074/jbc.AC119.010148
Dutton, L R, O'Neill, C L, Medina, R J & Brazil, D P 2019, ' No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cells ', The Journal of Biological Chemistry, vol. 294, no. 48, pp. 18041-18045 . https://doi.org/10.1074/jbc.AC119.010148
Canonical Gremlin1 (GREM1) signaling involves binding to and sequestering bone morphogenetic proteins (BMPs) in the extracellular matrix, preventing the activation of cognate BMP receptor. Exquisite temporospatial control of the GREM1-BMP interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5ce786f9a159ae945f783aab9b19cf
https://pubmed.ncbi.nlm.nih.gov/31604823
https://pubmed.ncbi.nlm.nih.gov/31604823
Publikováno v:
Pathak, V, Pathak, N M, O’Neill, C L, Guduric-Fuchs, J & Medina, R J 2019, ' Therapies for Type 1 Diabetes: Current Scenario and Future Perspectives ', Clinical Medicine Insights: Endocrinology and Diabetes, vol. 12 . https://doi.org/10.1177/1179551419844521
Clinical Medicine Insights: Endocrinology and Diabetes, Vol 12 (2019)
Clinical Medicine Insights. Endocrinology and Diabetes
Clinical Medicine Insights: Endocrinology and Diabetes, Vol 12 (2019)
Clinical Medicine Insights. Endocrinology and Diabetes
Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing β cells located in the endocrine pancreas in areas known as islets of Langerhans. The current standard-of-care for T1D is exogenous insulin replacement therapy. Recent de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e217c0d4cd3d23fc47caa358b2e7782c
https://pure.qub.ac.uk/en/publications/therapies-for-type-1-diabetes-current-scenario-and-future-perspectives(fdbeb15d-2d65-4cc6-a0b3-d3887924461a).html
https://pure.qub.ac.uk/en/publications/therapies-for-type-1-diabetes-current-scenario-and-future-perspectives(fdbeb15d-2d65-4cc6-a0b3-d3887924461a).html
Autor:
Christina L. O'Neill, Kiran J. McLoughlin, Sarah E. J. Chambers, Jasenka Guduric-Fuchs, Alan W. Stitt, Reinhold J. Medina
Publikováno v:
Frontiers in Medicine, Vol 5 (2018)
For over a decade various cell populations have been investigated for their vasoreparative potential. Cells with the capacity to promote blood vessel regeneration are commonly known as endothelial progenitor cells (EPCs); although such a definition i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::4fa6599772369c323cfb0e6746b8b506
https://www.frontiersin.org/article/10.3389/fmed.2018.00273/full
https://www.frontiersin.org/article/10.3389/fmed.2018.00273/full
Autor:
Karla M, O'Neill, David C, Campbell, Kevin S, Edgar, Eleanor K, Gill, Arya, Moez, Kiran J, McLoughlin, Christina L, O'Neill, Margaret, Dellett, Ciarán J, Hargey, Rawan A, Abudalo, Michael, O'Hare, Philip, Doyle, Tinrui, Toh, Joshua, Khoo, June, Wong, Cian M, McCrudden, Marco, Meloni, Coy, Brunssen, Henning, Morawietz, Mervin C, Yoder, Denise M, McDonald, Chris J, Watson, Alan W, Stitt, Andriana, Margariti, Reinhold J, Medina, David J, Grieve
Publikováno v:
Cardiovascular research. 116(2)
Cord blood-derived endothelial colony-forming cells (CB-ECFCs) are a defined progenitor population with established roles in vascular homeostasis and angiogenesis, which possess low immunogenicity and high potential for allogeneic therapy and are hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09548833f28b565df0bc7f536e0c2359
https://pubmed.ncbi.nlm.nih.gov/30937452
https://pubmed.ncbi.nlm.nih.gov/30937452
Autor:
Kiran J McLoughlin, Reinhold J. Medina, Cian M. McCrudden, Margaret Dellett, David J. Grieve, Henning Morawietz, Tinrui Toh, Arya Moez, Coy Brunssen, David Campbell, Philip Doyle, Alan W. Stitt, Joshua Khoo, Karla O'Neill, Christina L. O'Neill, Eleanor K Gill, Rawan A Abudalo, Andriana Margariti, Kevin S Edgar, Mervin C. Yoder, Ciaran Hargey
Publikováno v:
Oral Presentations.
Cord blood-derived endothelial colony-forming cells (CB-ECFCs) are a defined progenitor population with established roles in vascular homeostasis and angiogenesis, which possess low immunogenicity and high potential for allogeneic therapy. CB-ECFCs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9c2eedd9523a340d0250da61138c37c
https://doi.org/10.1136/heartjnl-2018-scf.8
https://doi.org/10.1136/heartjnl-2018-scf.8
Autor:
Aoife M. Egan, Jasenka Guduric-Fuchs, Sarah Chambers, Kiran J McLoughlin, Aaron Liew, Christina L. O'Neill, Reinhold J. Medina, Timothy O'Brien, Alan W. Stitt
Publikováno v:
Stem cells (Dayton, Ohio). 36(6)
Myeloid angiogenic cells (MACs) promote revascularization through the paracrine release of angiogenic factors and have been harnessed as therapeutic cells for many ischemic diseases. However, their pro-angiogenic properties have been suggested to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc86fe14b0b882e38f8c616d70024490
https://pubmed.ncbi.nlm.nih.gov/29484768
https://pubmed.ncbi.nlm.nih.gov/29484768
Autor:
Hal E. Broxmeyer, Manav Gupta, Nutan Prasain, Michael J. Ferkowicz, Christina L. O'Neill, Emma Reid, Brian M. Rapp, Olivier Elemento, Mervin C. Yoder, Younghee Lee, Jonathan Luke Meador, Ki Sung Hong, Sasidhar Vemula, Mohammad Reza Saadatzadeh, Alan W. Stitt, Man Ryul Lee, Hyung-Min Chung, Alexa Fett, Sherry L. Voytik-Harbin, Shahin Rafii, Reinhold J. Medina, Michael Ginsberg, Momoko Yoshimoto, Michael P. Murphy
Publikováno v:
Nature Biotechnology. 32:1151-1157
The ability to differentiate human pluripotent stem cells into endothelial cells with properties of cord-blood endothelial colony-forming cells (CB-ECFCs) may enable the derivation of clinically relevant numbers of highly proliferative blood vessel-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f36eff3f63a44309dfcf36fbdd4a70
https://doi.org/10.1038/nbt.3048
https://doi.org/10.1038/nbt.3048