Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Christina L Gardner"'
Autor:
Henry Ma, Joseph R Albe, Theron Gilliland, Cynthia M McMillen, Christina L Gardner, Devin A Boyles, Emily L Cottle, Matthew D Dunn, Jeneveve D Lundy, Noah Salama, Katherine J O'Malley, Ivona Pandrea, Tobias Teichert, Stacey Barrick, William B Klimstra, Amy L Hartman, Douglas S Reed
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1009946 (2022)
Venezuelan equine encephalitis virus (VEEV) is a positively-stranded RNA arbovirus of the genus Alphavirus that causes encephalitis in humans. Cynomolgus macaques are a relevant model of the human disease caused by VEEV and are useful in exploring pa
Externí odkaz:
https://doaj.org/article/a9ae6f80485742ccbbc0ae30019f063d
Autor:
Joseph R Albe, Henry Ma, Theron H Gilliland, Cynthia M McMillen, Christina L Gardner, Devin A Boyles, Emily L Cottle, Matthew D Dunn, Jeneveve D Lundy, Katherine J O'Malley, Noah Salama, Aaron W Walters, Ivona Pandrea, Tobias Teichert, William B Klimstra, Douglas S Reed, Amy L Hartman
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009308 (2021)
Aerosol exposure to eastern equine encephalitis virus (EEEV) can trigger a lethal viral encephalitis in cynomolgus macaques which resembles severe human disease. Biomarkers indicative of central nervous system (CNS) infection by the virus and lethal
Externí odkaz:
https://doaj.org/article/148107b18d2d4b4295040268973f0ef0
Autor:
Derek W Trobaugh, Chengqun Sun, Nishank Bhalla, Christina L Gardner, Matthew D Dunn, William B Klimstra
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1007867 (2019)
Eastern equine encephalitis virus (EEEV), a mosquito-borne RNA virus, is one of the most acutely virulent viruses endemic to the Americas, causing between 30% and 70% mortality in symptomatic human cases. A major factor in the virulence of EEEV is th
Externí odkaz:
https://doaj.org/article/d8899a9e015846fa931e6b83ecce4270
Autor:
Alan M Watson, Annika H Rose, Gregory A Gibson, Christina L Gardner, Chengqun Sun, Douglas S Reed, L K Metthew Lam, Claudette M St Croix, Peter L Strick, William B Klimstra, Simon C Watkins
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180486 (2017)
Whole-brain imaging is becoming a fundamental means of experimental insight; however, achieving subcellular resolution imagery in a reasonable time window has not been possible. We describe the first application of multicolor ribbon scanning confocal
Externí odkaz:
https://doaj.org/article/0e6afc151b5a45e0a619bd14bbc2f3f3
Autor:
Christina L Gardner, Jozef Hritz, Chengqun Sun, Dana L Vanlandingham, Timothy Y Song, Elodie Ghedin, Stephen Higgs, William B Klimstra, Kate D Ryman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2719 (2014)
Mosquito-borne chikungunya virus (CHIKV) is a positive-sense, single-stranded RNA virus from the genus Alphavirus, family Togaviridae, which causes fever, rash and severe persistent polyarthralgia in humans. Since there are currently no FDA licensed
Externí odkaz:
https://doaj.org/article/bd01950fdf944de7be1a383c6be4f8b4
Autor:
Kathryn C Meier, Christina L Gardner, Mikhail V Khoretonenko, William B Klimstra, Kate D Ryman
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000614 (2009)
Mosquito-borne yellow fever virus (YFV) causes highly lethal, viscerotropic disease in humans and non-human primates. Despite the availability of efficacious live-attenuated vaccine strains, 17D-204 and 17DD, derived by serial passage of pathogenic Y
Externí odkaz:
https://doaj.org/article/e3344edea59c4fedadf8e03f6df650d5
Autor:
Christina L. Gardner, Rebecca A. Erwin-Cohen, Bridget S. Lewis, Russell R. Bakken, Shelley P. Honnold, Pamela J. Glass, Crystal W. Burke
Publikováno v:
Methods and Protocols, Vol 7, Iss 3, p 42 (2024)
Venezuelan (VEE), eastern (EEE), and western (WEE) equine encephalitis viruses are encephalitic New World alphaviruses that cause periodic epizootic and epidemic outbreaks in horses and humans that may cause severe morbidity and mortality. Currently
Externí odkaz:
https://doaj.org/article/9adc199c54e243d488077b26024c26a5
Autor:
Crystal W. Burke, Christina L. Gardner, Aimee I. Goodson, Ashley E. Piper, Rebecca A. Erwin-Cohen, Charles E. White, Pamela J. Glass
Publikováno v:
Viruses, Vol 15, Iss 12, p 2351 (2023)
Venezuelan equine encephalitis virus (VEEV) outbreaks occur sporadically. Additionally, VEEV has a history of development as a biothreat agent. Yet, no FDA-approved vaccine or therapeutic exists for VEEV disease. The sporadic outbreaks present a chal
Externí odkaz:
https://doaj.org/article/3dce1b96f6184ab6ab65c974beeee562
Autor:
Christina L. Gardner, Chengqun Sun, Matthew D. Dunn, Theron C. Gilliland, Derek W. Trobaugh, Yutaka Terada, Douglas S. Reed, Amy L. Hartman, William B. Klimstra
Publikováno v:
Viruses; Volume 15; Issue 1; Pages: 5
The Department of Defense recently began an effort to improve and standardize virus challenge materials and efficacy determination strategies for testing therapeutics and vaccines. This includes stabilization of virus genome sequences in cDNA form wh
Autor:
Natasha M. Kafai, Lauren E. Williamson, Elad Binshtein, Soila Sukupolvi-Petty, Christina L. Gardner, Jaclyn Liu, Samantha Mackin, Arthur S. Kim, Nurgun Kose, Robert H. Carnahan, Ana Jung, Lindsay Droit, Douglas S. Reed, Scott A. Handley, William B. Klimstra, James E. Crowe, Michael S. Diamond
Publikováno v:
The Journal of experimental medicine. 219(4)
Venezuelan equine encephalitis virus (VEEV) remains a risk for epidemic emergence or use as an aerosolized bioweapon. To develop possible countermeasures, we isolated VEEV-specific neutralizing monoclonal antibodies (mAbs) from mice and a human immun