Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Christina L Gardner"'
Autor:
Christina L. Gardner, Rebecca A. Erwin-Cohen, Bridget S. Lewis, Russell R. Bakken, Shelley P. Honnold, Pamela J. Glass, Crystal W. Burke
Publikováno v:
Methods and Protocols, Vol 7, Iss 3, p 42 (2024)
Venezuelan (VEE), eastern (EEE), and western (WEE) equine encephalitis viruses are encephalitic New World alphaviruses that cause periodic epizootic and epidemic outbreaks in horses and humans that may cause severe morbidity and mortality. Currently
Externí odkaz:
https://doaj.org/article/9adc199c54e243d488077b26024c26a5
Autor:
Crystal W. Burke, Christina L. Gardner, Aimee I. Goodson, Ashley E. Piper, Rebecca A. Erwin-Cohen, Charles E. White, Pamela J. Glass
Publikováno v:
Viruses, Vol 15, Iss 12, p 2351 (2023)
Venezuelan equine encephalitis virus (VEEV) outbreaks occur sporadically. Additionally, VEEV has a history of development as a biothreat agent. Yet, no FDA-approved vaccine or therapeutic exists for VEEV disease. The sporadic outbreaks present a chal
Externí odkaz:
https://doaj.org/article/3dce1b96f6184ab6ab65c974beeee562
Autor:
Jinny L. Liu, Dan Zabetakis, Christina L. Gardner, Crystal W. Burke, Pamela J. Glass, Emily M. Webb, Lisa C. Shriver-Lake, George P. Anderson, James Weger-Lucarelli, Ellen R. Goldman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Venezuelan equine encephalitis virus (VEEV) is a mosquito borne alphavirus which leads to high viremia in equines followed by lethal encephalitis and lateral spread to humans. In addition to naturally occurring outbreaks, VEEV is a potential
Externí odkaz:
https://doaj.org/article/2c70083720fb45b09c0986debbe9c28b
Autor:
Henry Ma, Joseph R Albe, Theron Gilliland, Cynthia M McMillen, Christina L Gardner, Devin A Boyles, Emily L Cottle, Matthew D Dunn, Jeneveve D Lundy, Noah Salama, Katherine J O'Malley, Ivona Pandrea, Tobias Teichert, Stacey Barrick, William B Klimstra, Amy L Hartman, Douglas S Reed
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1009946 (2022)
Venezuelan equine encephalitis virus (VEEV) is a positively-stranded RNA arbovirus of the genus Alphavirus that causes encephalitis in humans. Cynomolgus macaques are a relevant model of the human disease caused by VEEV and are useful in exploring pa
Externí odkaz:
https://doaj.org/article/a9ae6f80485742ccbbc0ae30019f063d
Autor:
Christina L. Gardner, Chengqun Sun, Matthew D. Dunn, Theron C. Gilliland, Derek W. Trobaugh, Yutaka Terada, Douglas S. Reed, Amy L. Hartman, William B. Klimstra
Publikováno v:
Viruses, Vol 15, Iss 1, p 5 (2022)
The Department of Defense recently began an effort to improve and standardize virus challenge materials and efficacy determination strategies for testing therapeutics and vaccines. This includes stabilization of virus genome sequences in cDNA form wh
Externí odkaz:
https://doaj.org/article/39c888d0ed164b2b9f0bb2f6ad98b4ae
Autor:
Joseph R Albe, Henry Ma, Theron H Gilliland, Cynthia M McMillen, Christina L Gardner, Devin A Boyles, Emily L Cottle, Matthew D Dunn, Jeneveve D Lundy, Katherine J O'Malley, Noah Salama, Aaron W Walters, Ivona Pandrea, Tobias Teichert, William B Klimstra, Douglas S Reed, Amy L Hartman
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009308 (2021)
Aerosol exposure to eastern equine encephalitis virus (EEEV) can trigger a lethal viral encephalitis in cynomolgus macaques which resembles severe human disease. Biomarkers indicative of central nervous system (CNS) infection by the virus and lethal
Externí odkaz:
https://doaj.org/article/148107b18d2d4b4295040268973f0ef0
Autor:
Jinny L. Liu, Emily M. Webb, Dan Zabetakis, Crystal W. Burke, Christina L. Gardner, Pamela J. Glass, Patricia M. Legler, James Weger-Lucarelli, George P. Anderson, Ellen R. Goldman
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
A single domain antibody (clone CC3) previously found to neutralize a vaccine strain of the chikungunya virus (PRNT50 = 2. 5 ng/mL) was found to be broadly neutralizing. Clone CC3 is not only able to neutralize a wild-type (WT) strain of chikungunya
Externí odkaz:
https://doaj.org/article/29c401c161464a698b0ccea2b029bfa3
Autor:
Vanessa Raabe, Lilin Lai, Yong Xu, Chris Huerta, Dongli Wang, Stephanie M. Pouch, Crystal W. Burke, Ashley E. Piper, Christina L. Gardner, Pamela J. Glass, Mark J. Mulligan
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The human immune response to eastern equine encephalitis virus (EEEV) infection is poorly characterized due to the rarity of infection. We examined the humoral and cellular immune response to EEEV acquired from an infected donor via liver transplanta
Externí odkaz:
https://doaj.org/article/771ca7f64eac4eebb142cd45eec71853
Autor:
Derek W Trobaugh, Chengqun Sun, Nishank Bhalla, Christina L Gardner, Matthew D Dunn, William B Klimstra
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1007867 (2019)
Eastern equine encephalitis virus (EEEV), a mosquito-borne RNA virus, is one of the most acutely virulent viruses endemic to the Americas, causing between 30% and 70% mortality in symptomatic human cases. A major factor in the virulence of EEEV is th
Externí odkaz:
https://doaj.org/article/d8899a9e015846fa931e6b83ecce4270
Autor:
Whitney C. Lane, Matthew D. Dunn, Christina L. Gardner, L. K. Metthew Lam, Alan M. Watson, Amy L. Hartman, Kate D. Ryman, William B. Klimstra
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT Interferon alpha/beta (IFN-α/β) is a critical mediator of protection against most viruses, with host survival frequently impossible in its absence. Many studies have investigated the pathways involved in the induction of IFN-α/β after vi
Externí odkaz:
https://doaj.org/article/3f78f74c9de64ce7adeb89adcf60c60b