Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice

Autor: Robert A. Jacobs, Mostafa A. Aboouf, Christina Koester-Hegmann, Paola Muttathukunnel, Sofien Laouafa, Christian Arias-Reyes, Markus Thiersch, Jorge Soliz, Max Gassmann, Edith M. Schneider Gasser

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-19 (2021)

Robert Jacobs, Mostafa Aboouf, et al. examined the effect of erythropoietin (EPO) in hippocampal mitochondrial function and memory in two mouse models: one overexpressing EPO in the brain, and juvenile mice treated during three days with a high dose

Externí odkaz: https://doaj.org/article/28d43af59b814496ad5a6dc3b560f703

Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice

Autor: Christian Arias-Reyes, Edith M. Schneider Gasser, Mostafa A. Aboouf, Markus Thiersch, Christina Koester-Hegmann, Robert A. Jacobs, Sofien Laouafa, Paola Muttathukunnel, Max Gassmann, Jorge Soliz

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
Communications Biology

Erythropoietin (EPO) improves neuronal mitochondrial function and cognition in adults after brain injury and in those afflicted by psychiatric disorders. However, the influence of EPO on mitochondria and cognition during development remains unexplore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03dd4e2dcba8d83670d4bb3ef55701c
https://doi.org/10.1038/s42003-021-02465-8

Amylin/Calcitonin receptor–mediated signaling in POMC neurons influences energy balance and locomotor activity in chow-fed male mice

Autor: Bernd Coester, Christelle Le Foll, Thomas A. Lutz, Christina Koester-Hegmann

Amylin, a pancreatic hormone and neuropeptide, acts principally in the hindbrain to decrease food intake and has recently been shown to act as a neurotrophic factor to control the development of area postrema → nucleus of the solitary tract and arc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ebca889188514307497c1733616280
https://www.zora.uzh.ch/id/eprint/189144/

High-Altitude Cognitive Impairment Is Prevented by Enriched Environment Including Exercise via VEGF Signaling

Autor: Christina Koester-Hegmann, Harkaitz Bengoetxea, Dmitry Kosenkov, Markus Thiersch, Thomas Haider, Max Gassmann, Edith M. Schneider Gasser

Publikováno v: Frontiers in Cellular Neuroscience
Addi. Archivo Digital para la Docencia y la Investigación
instname
Frontiers in Cellular Neuroscience, Vol 12 (2019)

Exposure to hypobaric hypoxia at high altitude (above 2500 m asl) causes cognitive impairment, mostly attributed to changes in brain perfusion and consequently neuronal death. Enriched environment and voluntary exercise has been shown to improve cogn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17eb7792dd2f08c33baf97910978f267
https://pubmed.ncbi.nlm.nih.gov/30687018

Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects

Autor: Giovanna Bosshard, Steven J Moss, Christine Bole-Feysot, Jean-Marc Fritschy, Karine Siquier-Pernet, Patrick Nitschké, Olivier Alibeu, Ann-Kristina Fritz, Dennis Mircsof, David P. Wolfer, Florence Crestani, Markus Rudin, Steven A. Brown, Nathalie Boddaert, Rochelle M. Hines, Arnold Munnich, Jeanne Amiel, Petra Seebeck, Matej Žnidarič, Christina Koester, Nicolas Cagnard, Ludmila Gaspar, Maéva Langouët, Shiva K. Tyagarajan, Laurence Colleaux, Aileen Schröter, Marlène Rio, Sébastien Moutton, Katrina Prescott

Publikováno v: Nature Neuroscience
Nature Neuroscience, Nature Publishing Group, 2015, 18 (12), pp.1731-1736. ⟨10.1038/nn.4169⟩

The NONO protein has been characterized as an important transcriptional regulator in diverse cellular contexts. Here we show that loss of NONO function is a likely cause of human intellectual disability and that NONO-deficient mice have cognitive and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4021ff7fe23936013a6aae386fd0646
https://hal.archives-ouvertes.fr/hal-02088168