Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Christina K. Nolan"'
Autor:
Roland A. Cooper, Susan E. Leed, Qiang Zeng, Kevin A. Reynolds, Lacy Gaynor-Ohnstad, Lisa Xie, Hsiuling Lin, Jason C. Sousa, Jianbing Mu, Heather Gaona, Raul Olmeda, Martin J. Smilkstein, Brett R. Bayles, Brittney Potter, Michael K. Riscoe, Richard J. Sciotti, Papireddy Kancharla, Yuexin Li, Brian Vesely, Sovitj Pou, Sean R. Marcsisin, Chau Vuong, Qigui Li, Brandon S. Pybus, Lisa Read, Victor Melendez, Norma Roncal, Thu Lan Luong, Diana Caridha, Chad C. Black, Rozalia A. Dodean, Jing Zhang, Kirk Butler, Patrick K Tumwebaze, Charles E. Bane, Philip J. Rosenthal, Stephanie A Rasmussen, Mara Kreishman-Deitrick, Jane Xu Kelly, Frida G. Ceja, Ping Zhang, Christina K. Nolan
Publikováno v:
J Med Chem
The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent need for novel, affordable, and safe drugs for p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a8e0165bf6ef34369b69238cb312a6
https://doi.org/10.1021/acs.jmedchem.0c00539
https://doi.org/10.1021/acs.jmedchem.0c00539
Autor:
Anchalee Tungtaeng, John H. Adams, Christina K. Nolan, Pattaraporn Vanachayangkul, Piyaporn Saingam, Philip L. Smith, Matthew D Wegner, Gregory A. Reichard, Richard J. Sciotti, Brian Vesely, Rawiwan Imerbsin, Kevin C. Kobylinski, Chanikarn Kodchakorn, Chad C. Black, Alison Roth, Chaiyaporn Chaisatit, Luis A Lugo, Brandon S. Pybus, Mariusz Wojnarski
Previously, ivermectin (1–10 mg/kg) was shown to inhibit liver-stage development of Plasmodium berghei in orally dosed mice. Here, ivermectin showed inhibition of the in vitro development of Plasmodium cynomolgi schizonts (IC50 = 10.42 μM) and hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8682b0a3b1f0cf282ebc46b6c374733c
https://doi.org/10.1101/2020.04.27.065409
https://doi.org/10.1101/2020.04.27.065409
Autor:
Mariusz Wojnarski, Chanikarn Kodchakorn, Alison Roth, Luis A Lugo-Roman, Chaiyaporn Chaisatit, Pattaraporn Vanachayangkul, Philip L. Smith, Christina K. Nolan, John H. Adams, Chad C. Black, Kevin C. Kobylinski, Anchalee Tungtaeng, Rawiwan Imerbsin, Richard J. Sciotti, Brian Vesely, Piyaporn Saingam, Gregory A. Reichard, Brandon S. Pybus, Matthew D Wegner
Publikováno v:
Antimicrobial Agents and Chemotherapy
Previously, ivermectin (1 to 10 mg/kg of body weight) was shown to inhibit the liver-stage development of Plasmodium berghei in orally dosed mice. Here, ivermectin showed inhibition of the in vitro development of Plasmodium cynomolgi schizonts (50% i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef59f308db0f41823c4b3b4f1c70c6dd
https://pubmed.ncbi.nlm.nih.gov/32660993
https://pubmed.ncbi.nlm.nih.gov/32660993
Autor:
Yuexin Li, Kirk Butler, Brittney Potter, Qigui Li, Papireddy Kancharla, Roland A. Cooper, Thu Lan Luong, Heather Gaona, Jing Zhang, Richard J. Sciotti, Brian Vesely, Chau Vuong, Qiang Zeng, Sean R. Marcsisin, Michael K. Riscoe, Diana Caridha, Jason C. Sousa, Rolf W. Winter, Norma Roncal, Christina K. Nolan, Lisa Read, Rozalia A. Dodean, Lisa Xie, Lacy Gaynor-Ohnstad, Stephanie J. Huezo, Susan E. Leed, Hsiuling Lin, John C. Tan, Martin J. Smilkstein, Stephanie A Rasmussen, Jane Xu Kelly, Ping Zhang, Chad C. Black, Melissa T. Stephens, Mara Kreishman-Deitrick, Raul Olmeda, Victor Melendez, Sovitj Pou, Charles E. Bane
Malaria remains one of the deadliest diseases in the world today. Novel chemoprophylactic and chemotherapeutic antimalarials are needed to support the renewed eradication agenda. We have discovered a novel antimalarial acridone chemotype with dual-st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351c0f6f16032d54883ac7a5e8be555b
https://europepmc.org/articles/PMC6822569/
https://europepmc.org/articles/PMC6822569/
Autor:
Stephen S. Ferguson, Cornelia M. Smith, Jean B. Hatfield, Manda A. Edwards, Todd W. Stewart, Jasminder Sahi, Christina K. Nolan, Edward L. LeCluyse
Publikováno v:
Journal of Pharmaceutical Sciences. 101:3989-4002
Primary human hepatocytes are widely used for metabolic stability evaluations. However, there are limited data directly comparing phase I and phase II drug-metabolizing enzymes in fresh and cryopreserved hepatocytes prepared from the same human donor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c81ce95ec0960c3493784d353c9cb3c
https://doi.org/10.1002/jps.23262
https://doi.org/10.1002/jps.23262
Autor:
Gregory A. Reichard, Sean R. Marcsisin, Lisa H. Xie, Brittney Potter, Qigui Li, N. P. Dhammika Nanayakkara, Jason C. Sousa, Victor E. Zottig, Chau Vuong, Bryan Smith, Richard J. Sciotti, Brandon S. Pybus, Robert Paris, Philip L. Smith, Babu L. Tekwani, Larry A. Walker, Jing Zhang, Ping Zhang, Christina K. Nolan, Dehui Duan, Lisa Read
Cytochrome P450 (CYP) 2D metabolism is required for the liver-stage antimalarial efficacy of the 8-aminoquinoline molecule tafenoquine in mice. This could be problematic for Plasmodium vivax radical cure, as the human CYP 2D ortholog (2D6) is highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de54b8563e8e72b7ebcb6e6ef14602b
https://europepmc.org/articles/PMC4468667/
https://europepmc.org/articles/PMC4468667/
Autor:
Victor E. Zottig, Larry A. Walker, Gregory A. Reichard, Lisa H. Xie, Brittney Potter, Babu L. Tekwani, Christina K. Nolan, Qigui Li, Richard J. Sciotti, ThuLan Luong, Jason C. Sousa, H. M. T. Bandara Herath, Robert Paris, Sean R. Marcsisin, Lisa Read, N. P. Dhammika Nanayakkara, Ping Zhang, Chau Vuong, Jing Zhang, Dehui Duan, Philip L. Smith, Brandon S. Pybus
Publikováno v:
Antimicrobial agents and chemotherapy. 59(4)
Primaquine (PQ) metabolism by the cytochrome P450 (CYP) 2D family of enzymes is required for antimalarial activity in both humans (2D6) and mice (2D). Human CYP 2D6 is highly polymorphic, and decreased CYP 2D6 enzyme activity has been linked to decre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07484a5be50ae7d6f0802bf3ff98e64b
https://pubmed.ncbi.nlm.nih.gov/25645856
https://pubmed.ncbi.nlm.nih.gov/25645856