Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Christina K. Edgerly"'
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Akademický článek
The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity.
Autor: Cendrine Tourette, Francesca Farina, Rafael P Vazquez-Manrique, Anne-Marie Orfila, Jessica Voisin, Sonia Hernandez, Nicolas Offner, J Alex Parker, Sophie Menet, Jinho Kim, Jungmok Lyu, Si Ho Choi, Kerry Cormier, Christina K Edgerly, Olivia L Bordiuk, Karen Smith, Anne Louise, Michael Halford, Steven Stacker, Jean-Philippe Vert, Robert J Ferrante, Wange Lu, Christian Neri
Publikováno v: PLoS Biology, Vol 12, Iss 6, p e1001895 (2014)
The Wnt receptor Ryk is an evolutionary-conserved protein important during neuronal differentiation through several mechanisms, including γ-secretase cleavage and nuclear translocation of its intracellular domain (Ryk-ICD). Although the Wnt pathway
Externí odkaz: https://doaj.org/article/30fe5f15c42b4abcbb453493275b5e19
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2
The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models
Autor: Vanita Chopra, Lorraine Vollor, Patricia M. Cipicchio, Molly A. Lauver, Robert J. Ferrante, K. Lakshmi Narayanan, Steven M. Hersch, Richard B. Silverman, Aleksey G. Kazantsev, Luisa Quinti, Christina K. Edgerly, Jinho Kim, Soo Hyuk Choi
Publikováno v: Cell Reports, Vol 2, Iss 6, Pp 1492-1497 (2012)
Summary Inhibition of sirtuin 2 (SIRT2) deacetylase mediates protective effects in cell and invertebrate models of Parkinson's disease and Huntington's disease (HD). Here we report the in vivo efficacy of a brain-permeable SIRT2 inhibitor in two gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665bc92c50d4a29038a6f2d16b8d7ba1
http://www.sciencedirect.com/science/article/pii/S2211124712003828
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3
Chiral Cyclohexane 1,3-Diones as Inhibitors of Mutant SOD1-Dependent Protein Aggregation for the Treatment of ALS
Autor: Richard B. Silverman, Yinan Zhang, Wei Zhang, Yaoqiu Zhu, Donald R. Kirsch, Robert J. Ferrante, Christina K. Edgerly, Radhia Benmohamed, Jinho Kim, Richard I. Morimoto
Publikováno v: ACS Medicinal Chemistry Letters. 3:584-587
Cyclohexane 1,3-diones were identified as a class of molecules exhibiting a protective effect against mutant SOD1 induced toxicity in PC-12 cells, but an optimized analogue had little or no effect on life extension in the G93A SOD1 mouse model for am
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7625ba2172d4a90d2ba68dbb4dd77cb
https://doi.org/10.1021/ml3000963
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4
Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease
Autor: Wayne R. Matson, Christina K. Edgerly, Daniel J. Amante, Clemens R. Scherzer, Olivia L. Bordiuk, Steven M. Hersch, Karen M. Smith, Robert J. Ferrante, Samantha Matson, Jennifer P. Moody, Jinho Kim, H. Diana Rosas
Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1802(7-8):673-681
A major goal of current clinical research in Huntington's disease (HD) has been to identify preclinical and manifest disease biomarkers, as these may improve both diagnosis and the power for therapeutic trials. Although the underlying biochemical alt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b4f1e108a58b3e29279226aa217d04
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6
The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity
Autor: Olivia L. Bordiuk, Nicolas Offner, Anne-Marie Orfila, Robert J. Ferrante, Rafael P. Vázquez-Manrique, Michael M. Halford, Jinho Kim, Christina K. Edgerly, Wange Lu, Cendrine Tourette, Karen M. Smith, Anne Louise, Sonia Hernandez, Kerry Cormier, Jean-Philippe Vert, Si Ho Choi, Jungmok Lyu, J. Alex Parker, Francesca Farina, Steven A. Stacker, Christian Neri, Sophie Menet, Jessica Voisin
Publikováno v: PLoS Biology
PLoS Biology, Public Library of Science, 2014, 12 (6), pp.e1001895. ⟨10.1371/journal.pbio.1001895⟩
PLoS Biology, 2014, 12 (6), pp.e1001895. ⟨10.1371/journal.pbio.1001895⟩
PLoS Biology, Public Library of Science, 2014, 12 (6), pp.e1001895. 〈10.1371/journal.pbio.1001895〉
PLOS BIOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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PLoS Biology, Vol 12, Iss 6, p e1001895 (2014)
A study of Huntington's disease reveals that neurons might fail to cope with maintaining their function during the pre-symptomatic, pathogenic phases of HD, possibly due to the early repression of key longevity-promoting transcription factors by abno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427bed9b6b241ccd95a774a759d7f997
https://hal.archives-ouvertes.fr/hal-01076146/file/journal.pbio.1001895-1.pdf
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7
Uridine ameliorates the pathological phenotype in transgenic G93A-ALS mice
Autor: Steven W. Jones, Andrew C Cooper, Jinho Kim, Karen L. Smith, Kerry Cormier, James R. Rusche, Samantha T Carreiro, Robert J. Ferrante, Olivia L. Bordiuk, Jennifer P. Moody, Ting Li, Christina K. Edgerly, Daniel J. Amante
Publikováno v: Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases. 11(6)
There is strong evidence from studies in humans and animal models to suggest the involvement of energy metabolism defects in neurodegenerative diseases. Uridine, a pyrimidine nucleoside, has been suggested to be neuroprotective in neurological disord
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6516366694cbd4a098fd8d1a8825ee66
https://pubmed.ncbi.nlm.nih.gov/20565334
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8
Defining the role of syndecan-4 in mechanotransduction using surface-modification approaches
Autor: James D. Kubicek, Robert L. Steward, Jeffrey J. Fredberg, Andrew J. Kamien, Luke J. Duncan, Michael B. DiGiacomo, Chan Young Park, Elizabeth M. Morse, Hillary M. Barnes, Christina K. Edgerly, Robert M. Bellin, Philip R. LeDuc, Matthew J. Frigault, Chao-Min Cheng
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 106(52)
The ability of cells to respond to external mechanical stimulation is a complex and robust process involving a diversity of molecular interactions. Although mechanotransduction has been heavily studied, many questions remain regarding the link betwee
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265c22502d2880fbd3af00a619fa8e9c
https://pubmed.ncbi.nlm.nih.gov/20080785
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9
B19 The Wnt Receptor Ryk Reduces Neuronal Resistance Capacity By Repressing Foxo Activity During The Early Phases Of Huntingtin Pathogenicity
Autor: SH Choi, S Menet, Rafael P. Vázquez-Manrique, Jinho Kim, Christina K. Edgerly, Cendrine Tourette, Wange Lu, Jessica Voisin, Anne-Marie Orfila, S Hernandez, J Lyu, Robert J. Ferrante, J. A. Parker, Jean-Philippe Vert, S Stacker, Francesca Farina, Olivia L. Bordiuk, Karen M. Smith, Christian Neri, K Cormier, Nicolas Offner, M Halford, Anne Louise
Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 85:A15-A15
Background The ability of neurons to cope with the chronic stress induced by mutant protein expression in Huntington’s disease (HD) may determine the course of their decline and eventual demise. Although the pathophysiological importance of stress
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7c562766a764a0cd2956dd50f2bdb39
https://doi.org/10.1136/jnnp-2014-309032.47
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