Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Christina J. Yung"'
Autor:
Marta Olah, Vilas Menon, Naomi Habib, Mariko F. Taga, Yiyi Ma, Christina J. Yung, Maria Cimpean, Anthony Khairallah, Guillermo Coronas-Samano, Roman Sankowski, Dominic Grün, Alexandra A. Kroshilina, Danielle Dionne, Rani A. Sarkis, Garth R. Cosgrove, Jeffrey Helgager, Jeffrey A. Golden, Page B. Pennell, Marco Prinz, Jean Paul G. Vonsattel, Andrew F. Teich, Julie A. Schneider, David A. Bennett, Aviv Regev, Wassim Elyaman, Elizabeth M. Bradshaw, Philip L. De Jager
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Imbalance of microglial phenotypes in the aging brain might underlie their involvement in late onset neurodegenerative diseases. Here we report the population structure of microglia in the aged human brain and the reduction of a particular microglia
Externí odkaz:
https://doaj.org/article/70f5aedb5f20425e97be8410947e4a81
Autor:
Mariko Taga, Vladislav A. Petyuk, Charles White, Galina Marsh, Yiyi Ma, Hans-Ulrich Klein, Sarah M. Connor, Alexandra Kroshilina, Christina J. Yung, Anthony Khairallah, Marta Olah, Julie Schneider, Kyle Karhohs, Anne E. Carpenter, Richard Ransohoff, David A. Bennett, Andrea Crotti, Elizabeth M. Bradshaw, Philip L. De Jager
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Abstract Background Identified as an Alzheimer’s disease (AD) susceptibility gene by genome wide-association studies, BIN1 has 10 isoforms that are expressed in the Central Nervous System (CNS). The distribution of these isoforms in different cell
Externí odkaz:
https://doaj.org/article/c07b74e7cd5942fb90b040308c1a35a6
Autor:
Marta Olah, Ellis Patrick, Alexandra-Chloe Villani, Jishu Xu, Charles C. White, Katie J. Ryan, Paul Piehowski, Alifiya Kapasi, Parham Nejad, Maria Cimpean, Sarah Connor, Christina J. Yung, Michael Frangieh, Allison McHenry, Wassim Elyaman, Vlad Petyuk, Julie A. Schneider, David A. Bennett, Philip L. De Jager, Elizabeth M. Bradshaw
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Aging is associated with various changes in the brain, including transcription alteration. Here, Bradshaw and colleagues describe the transcriptome of aged human cortical microglia, and show age-related gene expression as related to neurodegeneration
Externí odkaz:
https://doaj.org/article/88714dece0ad45ec8217ad53d576eddd
Autor:
Jean Paul Vonsattel, David A. Bennett, Christina J. Yung, Naomi Habib, Julie A. Schneider, Mariko Taga, Marta Olah, Guillermo Coronas-Samano, Aviv Regev, Philip L. De Jager, Anthony Khairallah, Andrew F. Teich, Yiyi Ma, Vilas Menon
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Andrew F. Teich, Danielle Dionne, Philip L. De Jager, Aviv Regev, Julie A. Schneider, Roman Sankowski, Jean Paul Vonsattel, Jeffrey Helgager, Jeffrey A. Golden, Marta Olah, Rani A. Sarkis, Dominic Grün, Vilas Menon, Wassim Elyaman, Naomi Habib, Elizabeth M. Bradshaw, Guillermo Coronas-Samano, Alexandra Kroshilina, Anthony Khairallah, Mariko Taga, David A. Bennett, Page B. Pennell, Christina J. Yung, Marco Prinz, Yiyi Ma, Garth Rees Cosgrove, Maria Cimpean
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
The extent of microglial heterogeneity in humans remains a central yet poorly explored question in light of the development of therapies targeting this cell type. Here, we investigate the population structure of live microglia purified from human cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47464d4a3e1542de898c6586fe4b11ff
https://hdl.handle.net/21.11116/0000-0007-AAE0-C21.11116/0000-0007-85C5-4
https://hdl.handle.net/21.11116/0000-0007-AAE0-C21.11116/0000-0007-85C5-4
Autor:
Philip L. De Jager, David A. Bennett, Mariko Taga, Bernard Ng, Ayla Ergun, Chris Gaiteri, William Casazza, Julie A. Schneider, Maria Cimpean, Christina J. Yung, Ellis Patrick, Elizabeth M. Bradshaw, Sara Mostafavi
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1008120 (2020)
PLoS Computational Biology
PLoS Computational Biology
Complexity of cell-type composition has created much skepticism surrounding the interpretation of bulk tissue transcriptomic studies. Recent studies have shown that deconvolution algorithms can be applied to computationally estimate cell-type proport
Autor:
Brooke Rhead, Sarah M. Connor, Lisa F. Barcellos, Christina J. Yung, Howard L. Weiner, Jia Liu, Daniel Felsky, Nikolaos A. Patsopoulos, Pia Kivisäkk, Belinda J. Kaskow, Xiaorong Shao, Tina Roostaei, Hans-Ulrich Klein, Philip L. De Jager, Yiyi Ma, Alexandra Kroshilina
We establish a genome-wide map of DNA methylation quantitative trait locus (mQTL) effects in CD4+T cells isolated from multiple sclerosis (MS) patients. Utilizing this map in a colocalization analysis, we identify 19 loci where the same haplotype dri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae1e92aec84bf0f189daa2bd876153e6
https://doi.org/10.1101/2020.07.11.198721
https://doi.org/10.1101/2020.07.11.198721
Autor:
Christina J. Yung, Yiyi Ma, Alexandra Kroshilina, Richard M. Ransohoff, Hans-Ulrich Klein, David A. Bennett, Julie A. Schneider, Charles C. White, Philip L. De Jager, Marta Olah, Elizabeth M. Bradshaw, Anne E. Carpenter, Galina Marsh, Anthony Khairallah, Sarah M. Connor, Andrea Crotti, Kyle W. Karhohs, Vladislav A. Petyuk, Mariko Taga
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Background Identified as an Alzheimer’s disease (AD) susceptibility gene by genome wide-association studies, BIN1 has 10 isoforms that are expressed in the Central Nervous System (CNS). The distribution of these isoforms in different cell types, as
Autor:
Parham Nejad, David A. Bennett, Alexandra-Chloé Villani, Ellis Patrick, Jishu Xu, Vlad Petyuk, Katie J. Ryan, Marta Olah, Christina J. Yung, Julie A. Schneider, Alifiya Kapasi, Michael Frangieh, Maria Cimpean, Sarah M. Connor, Wassim Elyaman, Elizabeth M. Bradshaw, Philip L. De Jager, Allison McHenry, Paul D. Piehowski, Charles C. White
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Nature Communications
Nature Communications
With a rapidly aging global human population, finding a cure for late onset neurodegenerative diseases has become an urgent enterprise. However, these efforts are hindered by the lack of understanding of what constitutes the phenotype of aged human m
Autor:
Kenneth G. Trieu, Wei Wang, Kruti R. Patel, Xingbin Ai, Christina J. Yung, Thomas S Buttrick, Wassim Elyaman, Samia J. Khoury
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
T helper 9 (Th9) cells are effector CD4+ T cells that are characterized by the production of interleukin-9 (IL-9) and have been associated with allergic responses. Here, we found that the expression of the transcription factor forkhead box O1 (Foxo1)