Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christina J. Matheny"'
Autor:
Michael C. Bassik, Michael T. McManus, Obdulio Piloto, Christina J. Matheny, Alicia J. Donnelly, Martin Kampmann, Michael L. Cleary, Michael C. Wei, Rachel E. Rau, Patrick Brown, David E. Solow-Cordero, Donna M. Bouley, Masayuki Iwasaki, Jonathan S. Weissman
Publikováno v:
Chemistry & biology, vol 20, iss 11
SummaryPhenotypic high-throughput chemical screens allow for discovery of small molecules that modulate complex phenotypes and provide lead compounds for novel therapies; however, identification of the mechanistically relevant targets remains a major
Autor:
Jay R. Lieberman, Rosa M. Guzzo, Christina J. Matheny, Hicham Drissi, Maren E. Speck, Do Y. Soung, Laleh Talebian, Nancy A. Speck
Publikováno v:
Journal of Bone and Mineral Research. 27:1585-1597
Runx1 is expressed in skeletal elements, but its role in fracture repair has not been analyzed. We created mice with a hypomorphic Runx1 allele (Runx1(L148A) ) and generated Runx1(L148A/-) mice in which >50% of Runx1 activity was abrogated. Runx1(L14
Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles
Autor:
Caroline L. Speck, Nancy A. Speck, Maren E. Speck, Michael C. Regan, Yunpeng Zhou, Stephen M Griffey, Patrick R. Cushing, Ting Lei Gu, Liya Roudaia, John H. Bushweller, Christina J. Matheny, Takeshi Corpora, Miki Newman
Publikováno v:
The EMBO Journal. 26:1163-1175
Monoallelic RUNX1 mutations cause familial platelet disorder with predisposition for acute myelogenous leukemia (FPD/AML). Sporadic mono- and biallelic mutations are found at high frequencies in AML M0, in radiation-associated and therapy-related mye
Autor:
Kevin S. Smith, Francesca Ficara, Chenwei Lin, Zhong Wang, Michael L. Cleary, Christina J. Matheny, Stephen H.K. Wong, Masayuki Iwasaki
SummaryAcute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. We demonstrate here that GSK-3 maintains the MLL leukemia stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7e7346ff67e92cc85aa81d0da8371e
https://europepmc.org/articles/PMC2919232/
https://europepmc.org/articles/PMC2919232/
Autor:
James R. Downing, Christina J. Matheny, John L. Rinn, Masayuki Iwasaki, Michael L. Cleary, Gary J. Spencer, Howard Y. Chang, Daniela Witten, Sheila A. Shurtleff, Tim C. P. Somervaille
Publikováno v:
Cell stem cell. 4(2)
SummaryThe genetic programs that promote retention of self-renewing leukemia stem cells (LSCs) at the apex of cellular hierarchies in acute myeloid leukemia (AML) are not known. In a mouse model of human AML, LSCs exhibit variable frequencies that co
Autor:
Terryl Stacy, Marella F. T. R. de Bruijn, Nancy A. Speck, Trista E. North, Christina J. Matheny
Publikováno v:
Stem cells (Dayton, Ohio). 22(2)
The transcription factor Runx1 marks all functional hematopoietic stem cells (HSCs) in the embryo and is required for their generation. Mutations in Runx1 are found in approximately 25% of acute leukemias and in familial platelet disorder, suggesting
Autor:
Jerónimo Bravo, Christina J. Matheny, Jiangli Yan, Nancy A. Speck, Alan J. Warren, Zhe Li, Takeshi Corpora, John H. Bushweller
Publikováno v:
The Journal of biological chemistry. 278(35)
Core-binding factors (CBFs) are a small family of heterodimeric transcription factors that play critical roles in hematopoiesis and in the development of bone, stomach epithelium, and proprioceptive neurons. Mutations in CBF genes are found in leukem
Autor:
Masayuki Iwasaki, Obdulio Piloto, Martin Kampmann, Donna M. Bouley, Michael C. Bassik, Rachel E. Rau, Michael T. McManus, Alicia J. Donnelly, Jonathan S. Weissman, David E. Solow-Cordero, Michael C. Wei, Michael L. Cleary, Christina J. Matheny, Patrick Brown
Publikováno v:
Blood. 122:171-171
There is a critical need for new agents with novel therapeutic targets and improved safety profiles in high-risk acute lymphoblastic leukemia (ALL), which is a significant cause of morbidity and mortality in pediatric and adult populations. Phenotypi
Autor:
Maren E. Speck, Takeshi Corpora, Christina J. Matheny, John H. Bushweller, Nancy A. Speck, Ting Lei Gu
Publikováno v:
Blood. 104:464-464
Runx1 and CBF β are the DNA-binding and non DNA-binding subunits of a core-binding factor that is required for hematopoiesis, and that is frequently mutated in leukemia. Runx2 is the DNA-binding subunit of a core-binding factor required for bone for