Výsledky vyhledávání - "Christina Ioannidis"

Serine/threonine phosphatase PP2A is essential for optimal B cell function

Autor: Hao Li, George C. Tsokos, Pui Lee, Amir Sharabi, Michihito Kono, Maria Tsokos, Esra Meidan, John P. Manis, Vasileios C. Kyttaris, José C. Crispín, Christina Ioannidis, Sokratis A. Apostolidis, Shuilian Yu, Wen Liang Pan, Noe Rodriguez Rodriguez

Publikováno v: JCI Insight. 5

Protein phosphatase 2A (PP2A), a serine/threonine phosphatase, has been shown to control T cell function. We found that in vitro–activated B cells and B cells from various lupus-prone mice and patients with systemic lupus erythematosus display incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0105c7949420cafcd9d6c6c3b012cca0
https://doi.org/10.1172/jci.insight.130655

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Stat3 promotes IL-10 expression in lupus T cells through trans- activation and chromatin remodeling

Autor: George C. Tsokos, José C. Crispín, Noe Rodriguez Rodriguez, Christina Ioannidis, Vasileios C. Kyttaris, Alexandros P. Grammatikos, Thomas Rauen, Christian M. Hedrich, Sokratis A. Apostolidis

Publikováno v: Proceedings of the National Academy of Sciences. 111:13457-13462

The immune-regulatory cytokine IL-10 plays a central role during innate and adaptive immune responses. IL-10 is elevated in the serum and tissues of patients with systemic lupus erythematosus (SLE), an autoimmune disorder characterized by autoantibod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50659a4711873f2884c795db28e78da
https://doi.org/10.1073/pnas.1408023111

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cAMP Responsive Element Modulator (CREM) α Mediates Chromatin Remodeling of CD8 during the Generation of CD3+CD4−CD8− T Cells

Autor: Christina Ioannidis, Tomohiro Koga, Thomas Rauen, Sokratis A. Apostolidis, Noe Rodriguez Rodriguez, José C. Crispín, Christian M. Hedrich, Vasileios C. Kyttaris, George C. Tsokos

Publikováno v: Journal of Biological Chemistry. 289:2361-2370

TCR-αβ(+)CD3(+)CD4(-)CD8(-) "double negative" T cells are expanded in the peripheral blood of patients with systemic lupus erythematosus (SLE) and lupus-prone mice. Double negative T cells have been claimed to derive from CD8(+) cells that down-reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b3195501b130650d09ac31f449351c
https://doi.org/10.1074/jbc.m113.523605

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CD3-T Cell Receptor Co-stimulation through SLAMF3 and SLAMF6 Receptors Enhances RORγt Recruitment to the IL17A Promoter in Human T Lymphocytes

Autor: George C. Tsokos, Christian M. Hedrich, Madhumouli Chatterjee, Christina Ioannidis, Thomas Rauen, Cox Terhorst

Publikováno v: Journal of Biological Chemistry. 287:38168-38177

Th17 lymphocytes play a key role during immune responses against bacteria and fungi and are involved in the pathophysiology of multiple autoimmune disorders. The co-stimulatory molecules SLAMF3 and SLAMF6 have been implicated in the formation of Th17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49045132b2a416fc977dc1941705a85c
https://doi.org/10.1074/jbc.m112.415067

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Influenza a Blockers with Reduced Resistance Formation

Autor: Kolocouris, Antonios Johnson, F. Brent Zell, Roland and Schmidtke, Michaela Sureda, Francesc X. Cross, Timothy A. and Fedida, David Tzitzoglaki, Christina Ioannidis, Harris and Hoffman, Anja Lopez-Querol, Marta Wright, Anna K. Kwan, Daniel McGuire, Kelly Busath, David D.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::75e4ea71ac9d925887174579efcb1799
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3160543

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Solid-State NMR Characterization of S31N M2 Transmembrane Domain Bound to Novel Adamantanes with Persistent In Vitro Efficacy

Autor: Wright, Anna K. Hung, Ivan Tzitzoglaki, Christina Ioannidis, Harris Busath, David D. Kolocouris, Antonios Cross, Timothy A.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::6df53fd2759d2c26766a96511c3377c8
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3160545

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cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease

Autor: José C. Crispín, Tomohiro Koga, Thomas Rauen, George C. Tsokos, Christina Ioannidis, Vasileios C. Kyttaris, Melissa C. Zajdel, Christian M. Hedrich

Publikováno v: The Journal of biological chemistry. 288(44)

T cell receptor-αβ(+) CD3(+)CD4(-)CD8(-) "double-negative" T cells are expanded in the peripheral blood of patients with systemic lupus erythematosus and autoimmune lymphoproliferative syndrome. In both disorders, double-negative T cells infiltrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc85251eba2cd9a67b3d1734d7f0d57
https://pubmed.ncbi.nlm.nih.gov/24047902

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cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus

Autor: José C. Crispín, Mindy S. Lo, Vasileios C. Kyttaris, Christina Ioannidis, George C. Tsokos, Thomas Rauen, Christian M. Hedrich, Sokratis A. Apostolidis

Appropriate expression of IL-2 plays a central role during the priming and differentiation of T cells. A tight balance between IL-2 and the effector cytokine IL-17A is essential for immune homeostasis. Epigenetic mechanisms have been documented as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c079022b4f38f179789eec9b34adcfc
https://europepmc.org/articles/PMC3478624/

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