Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christina Heroven"'
Autor:
Yangci Liu, Haoming Zhai, Helen Alemayehu, Jérôme Boulanger, Lee J. Hopkins, Alicia C. Borgeaud, Christina Heroven, Jonathan D. Howe, Kendra E. Leigh, Clare E. Bryant, Yorgo Modis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract NLRP3 induces caspase-1-dependent pyroptotic cell death to drive inflammation. Aberrant activity of NLRP3 occurs in many human diseases. NLRP3 activation induces ASC polymerization into a single, micron-scale perinuclear punctum. Higher reso
Externí odkaz:
https://doaj.org/article/0dd2c4667aa94b67b8bb0ece60d3f339
Autor:
Gina Dörpholz, Arunima Murgai, Jerome Jatzlau, Daniel Horbelt, Mohammad Poorgholi Belverdi, Christina Heroven, Isabelle Schreiber, Gisela Wendel, Karen Ruschke, Sigmar Stricker, Petra Knaus
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract Elaborate regulatory networks of the Bone Morphogenetic Protein (BMP) pathways ensure precise signalling outcome during cell differentiation and tissue homeostasis. Here, we identified IRS4 as a novel regulator of BMP signal transduction and
Externí odkaz:
https://doaj.org/article/1eb3e5fa24f24e5eb5f151ca67e39838
Autor:
Marco Preussner, Karine F. Santos, Jonathan Alles, Christina Heroven, Florian Heyd, Markus C. Wahl, Gert Weber
Publikováno v:
Acta crystallographica / Section D 78(11), 1373-1383 (2022). doi:10.1107/S2059798322009755
Acta crystallographica / Section D 78(11), 1373 - 1383 (2022). doi:10.1107/S2059798322009755
Small nuclear ribonucleoprotein complexes (snRNPs) represent the main subunits of the spliceosome. While the assembly of the snRNP core particles has be
Small nuclear ribonucleoprotein complexes (snRNPs) represent the main subunits of the spliceosome. While the assembly of the snRNP core particles has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c356caa8395e54af49f8fc088c4a8a
Autor:
Yorgo Modis, Jonathan D. Howe, Yangci Liu, Haoming Zhai, Clare E. Bryant, Lee Hopkins, Helen Alemayehu, Alicia C. Borgeaud, Jérôme Boulanger, Christina Heroven
NLRP3 induces caspase-1-dependent pyroptotic cell death to drive inflammation. Aberrant activity of NLRP3 occurs in many human diseases. NLRP3 activation induces ASC polymerization into a single, micron-scale perinuclear punctum. Higher resolution im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05b861aa4c40be6d50903d7a5be66101
https://doi.org/10.1101/2021.09.20.461078
https://doi.org/10.1101/2021.09.20.461078
Autor:
Vikram Thimaradka, Christina Heroven, A. Radu Aricescu, Itaru Hamachi, Tomonori Tamura, Jae Hoon Oh, Michisuke Yuzaki
Publikováno v:
Bioorganic & medicinal chemistry
The ability to incorporate a desired functionality into proteins of interest in a site-specific manner can provide powerful tools for investigating biological systems and creating therapeutic conjugates. However, there are not any universal methods t
Autor:
Petra Knaus, Gina Dörpholz, Christina Heroven, Gisela Wendel, Mohammad Poorgholi Belverdi, Arunima Murgai, Jerome Jatzlau, Sigmar Stricker, Isabelle Schreiber, Daniel Horbelt, Karen Ruschke
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Scientific Reports
Scientific Reports
Elaborate regulatory networks of the Bone Morphogenetic Protein (BMP) pathways ensure precise signalling outcome during cell differentiation and tissue homeostasis. Here, we identified IRS4 as a novel regulator of BMP signal transduction and provide
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 71:1421-1428
In eukaryotes, the removal of nuclear noncoding sequences (pre-mRNA splicing) is catalyzed by the spliceosome, which consists of five ribonucleoprotein particles (U1, U2, U4, U5 and U6 snRNPs, each with a respective snRNA) and a plethora of protein f
Autor:
Jeffrey N. Savas, Joris de Wit, Jo Begbie, Christina Heroven, Alexandra C. Smith, Jonathan Elegheert, Vedrana Cvetkovska, Hiro Furukawa, Michael C. Regan, Wanyi Jia, Amber J. Clayton, Samuel N. Smukowski, A. Radu Aricescu, Ann Marie Craig, Kristel M. Vennekens
Publikováno v:
Neuron
'Neuron ', vol: 95, pages: 896-913 (2017)
'Neuron ', vol: 95, pages: 896-913 (2017)
Summary Neuroligin-neurexin (NL-NRX) complexes are fundamental synaptic organizers in the central nervous system. An accurate spatial and temporal control of NL-NRX signaling is crucial to balance excitatory and inhibitory neurotransmission, and pert
Autor:
Nicole Holton, Jean D. Beggs, Sina Mozaffari Jovin, Markus C. Wahl, Anna Christina Heroven, Karine F. Santos, Vanessa F. Cristão, Gert Weber, Reinhard Lührmann
Publikováno v:
Weber, G, Santos, K F, Heroven, A C, Holton, N, Wahl, M C, Cristão, V F, Beggs, J D, Jovin, S M & Lührmann, R 2013, ' Structural basis for dual roles of Aar2p in U5 snRNP assembly ', Genes & Development, vol. 27, no. 5, pp. 525-540 . https://doi.org/10.1101/gad.213207.113
Genes and Development
Genes and Development
Yeast U5 small nuclear ribonucleoprotein particle (snRNP) is assembled via a cytoplasmic precursor that contains the U5-specific Prp8 protein but lacks the U5-specific Brr2 helicase. Instead, pre-U5 snRNP includes the Aar2 protein not found in mature