Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Christina H. Tu"'
Autor:
Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H. Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G. Aleph Prieto, Leslie M. Thompson, Joan S. Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jones
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d74b2e4cb1a84ae98fd95f8389c0a7c0
Autor:
Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H. Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G. Aleph Prieto, Leslie M. Thompson, Joan S. Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jones
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Abstract The discovery of TREM2 as a myeloid-specific Alzheimer’s disease (AD) risk gene has accelerated research into the role of microglia in AD. While TREM2 mouse models have provided critical insight, the normal and disease-associated functions
Externí odkaz:
https://doaj.org/article/2fc5155c4b834bdf97f0aa5db0218942
Autor:
Amanda McQuade, Morgan Coburn, Christina H. Tu, Jonathan Hasselmann, Hayk Davtyan, Mathew Blurton-Jones
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-13 (2018)
Abstract Background Microglia, the principle immune cells of the brain, play important roles in neuronal development, homeostatic function and neurodegenerative disease. Recent genetic studies have further highlighted the importance of microglia in n
Externí odkaz:
https://doaj.org/article/ea78a974e25e4485bf7ae591608e7925
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 1, Pp 165-173 (2007)
Neuronal degeneration linked to apoptosis can be inhibited by a family of proteins known as inhibitors of apoptosis proteins (IAPs). We examined three members of the IAP family that are implicated in the regulation of neuronal death. We assessed NAIP
Externí odkaz:
https://doaj.org/article/3e7aa7fbe68d48c28d156f91af0f9b53
Autor:
Morgan A. Coburn, Amanda McQuade, Christina H. Tu, Jonathan Hasselmann, Hayk Davtyan, Mathew Blurton-Jones
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-13 (2018)
Molecular Neurodegeneration
McQuade, Amanda; Coburn, Morgan; Tu, Christina H; Hasselmann, Jonathan; Davtyan, Hayk; & Blurton-Jones, Mathew. (2018). Development and validation of a simplified method to generate human microglia from pluripotent stem cells.. Molecular neurodegeneration, 13(1), 67. doi: 10.1186/s13024-018-0297-x. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6978s3qz
Molecular Neurodegeneration
McQuade, Amanda; Coburn, Morgan; Tu, Christina H; Hasselmann, Jonathan; Davtyan, Hayk; & Blurton-Jones, Mathew. (2018). Development and validation of a simplified method to generate human microglia from pluripotent stem cells.. Molecular neurodegeneration, 13(1), 67. doi: 10.1186/s13024-018-0297-x. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6978s3qz
Background Microglia, the principle immune cells of the brain, play important roles in neuronal development, homeostatic function and neurodegenerative disease. Recent genetic studies have further highlighted the importance of microglia in neurodegen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00dc6f44aae49bf37bf9c81afb3fbc80
http://link.springer.com/article/10.1186/s13024-018-0297-x
http://link.springer.com/article/10.1186/s13024-018-0297-x
Autor:
Christel Claes, Jonathan Hasselmann, Emma Danhash, Jorge Silva, Hayk Davtyan, Tau En Lim, Morgan A. Coburn, Sepideh Kiani Shabestari, Amit Jairaman, Jean Paul Chadarevian, Christina H. Tu, Mathew Blurton-Jones, Michael D. Cahalan
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1af97fa74569c6305ebf8b70effc872
https://doi.org/10.1002/alz.041539
https://doi.org/10.1002/alz.041539
Autor:
Karla Echeverria, Mahshad Kolahdouzan, Christel Claes, Amanda McQuade, Robert C. Spitale, Taylor Nakayama, Hayk Davtyan, Jonathan Hasselmann, Morgan A. Coburn, Brian J. Cummings, Luke M. Healy, Ricardo Azevedo, Mathew Blurton-Jones, Sepideh Kiani Shabestari, Dario X. Figueroa Velez, Whitney England, Nicole G. Coufal, Claudia Z. Han, Christina H. Tu, Christopher K. Glass, Sunil P. Gandhi
Publikováno v:
Neuron. 103(6)
iPSC-derived microglia offer a powerful tool to study microglial homeostasis and disease-associated inflammatory responses. Yet, microglia are highly sensitive to their environment, exhibiting transcriptomic deficiencies when kept in isolation from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e320f28b7dad58eed04c01d21b82ce9
https://pubmed.ncbi.nlm.nih.gov/31932736
https://pubmed.ncbi.nlm.nih.gov/31932736
Publikováno v:
Acta Biomaterialia. 9:6369-6380
The fate of adult stem cells can be influenced by physical cues, including nanotopography. However, the response of human embryonic stem cells (hESCs) to dimensionally well-defined nanotopography is unknown. Using imprint lithography, we prepared wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7eedb7f5fed544c458a77e385d83f52
https://doi.org/10.1016/j.actbio.2013.01.036
https://doi.org/10.1016/j.actbio.2013.01.036
Autor:
Anne Marion Taylor, Noo Li Jeon, Christina H. Tu, Victoria M. Perreau, Nicole C. Berchtold, Carl W. Cotman
Publikováno v:
The Journal of Neuroscience. 29:4697-4707
Using a novel microfluidic chamber that allows the isolation of axons without contamination by nonaxonal material, we have for the first time purified mRNA from naive, matured CNS axons, and identified the presence of >300 mRNA transcripts. We demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d839a145357861c14acce3133ea360
https://doi.org/10.1523/jneurosci.6130-08.2009
https://doi.org/10.1523/jneurosci.6130-08.2009
Autor:
Yumay Chen, Seok-Ki Choi, Pamela T. Wong, James R. Baker, Alexa Coulter, Shengzhuang Tang, Tannaz Faal, Christina H. Tu, Matthew A. Inlay
Publikováno v:
Molecular bioSystems, vol 11, iss 3
Faal, T; Wong, PT; Tang, S; Coulter, A; Chen, Y; Tu, CH; et al.(2015). 4-Hydroxytamoxifen probes for light-dependent spatiotemporal control of Cre-ER mediated reporter gene expression. Molecular BioSystems, 11(3), 783-790. doi: 10.1039/c4mb00581c. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8781924k
Faal, T; Wong, PT; Tang, S; Coulter, A; Chen, Y; Tu, CH; et al.(2015). 4-Hydroxytamoxifen probes for light-dependent spatiotemporal control of Cre-ER mediated reporter gene expression. Molecular BioSystems, 11(3), 783-790. doi: 10.1039/c4mb00581c. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8781924k
© 2015 The Royal Society of Chemistry. The tamoxifen inducible Cre-ER/loxP system provides tissue specific temporal control of gene recombination events, and can be used to induce expression of reporter genes (e.g. GFP, LacZ) for lineage tracing stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476fd05dfdc26b517eda978be04f938b
https://pubmed.ncbi.nlm.nih.gov/25502239
https://pubmed.ncbi.nlm.nih.gov/25502239