Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity.

Autor: Dante Rotili, Domenico Tarantino, Biagina Marrocco, Christina Gros, Véronique Masson, Valérie Poughon, Fréderic Ausseil, Yanqi Chang, Donatella Labella, Sandro Cosconati, Salvatore Di Maro, Ettore Novellino, Michael Schnekenburger, Cindy Grandjenette, Celine Bouvy, Marc Diederich, Xiaodong Cheng, Paola B Arimondo, Antonello Mai

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96941 (2014)

Chemical manipulations performed on the histone H3 lysine 9 methyltransferases (G9a/GLP) inhibitor BIX-01294 afforded novel desmethoxyquinazolines able to inhibit the DNA methyltransferase DNMT3A at low micromolar levels without any significant inhib

Externí odkaz: https://doaj.org/article/281a01d650e04497b3316ad698b79eb4

Correction: Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells

Autor: Clemens Zwergel, Michael Schnekenburger, Federica Sarno, Cecilia Battistelli, Maria Cristina Manara, Giulia Stazi, Roberta Mazzone, Rossella Fioravanti, Christina Gros, Frédéric Ausseil, Cristina Florean, Angela Nebbioso, Raffaele Strippoli, Toshikazu Ushijima, Katia Scotlandi, Marco Tripodi, Paola B. Arimondo, Lucia Altucci, Marc Diederich, Antonello Mai, Sergio Valente

Publikováno v: Clinical Epigenetics. 14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b22e2861b135099f339db55504a34a0
https://doi.org/10.1186/s13148-022-01339-y

Mir324 knockout regulates the structure of dendritic spines and impairs hippocampal long-term potentiation

Autor: Emma V. Parkins, Darrin H. Brager, Jeffrey K. Rymer, John M. Burwinkel, Diego Rojas, Durgesh Tiwari, Yueh-Chiang Hu, Christina Gross

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract MicroRNAs are an emerging class of synaptic regulators. These small noncoding RNAs post-transcriptionally regulate gene expression, thereby altering neuronal pathways and shaping cell-to-cell communication. Their ability to rapidly alter gen

Externí odkaz: https://doaj.org/article/07598c5410004486bbda98f3ddb1749f

Feasibility of individualized home exercise programs for patients with head and neck cancer-study protocol and first results of a multicentre single-arm intervention trial (OSHO #94).

Autor: Sabine Felser, Julia Rogahn, Änne Glass, Lars Arne Bonke, Daniel Fabian Strüder, Jana Stolle, Susann Schulze, Markus Blaurock, Ursula Kriesen, Christian Junghanss, Christina Grosse-Thie

Publikováno v: PLoS ONE, Vol 19, Iss 8, p e0301304 (2024)

IntroductionPatients with head and neck cancer (PwHNC) benefit from targeted exercise interventions: symptom relief, compensation for dysfunction, improvement in quality of life (QoL). Data on acceptance physical interventions in PwHNC are rare. The

Externí odkaz: https://doaj.org/article/e402af1068c841ddbe42dbff3e803421

Side‐Chain Effects on the 1‐(Bis‐aryl‐methylidene)‐[3]ferrocenophane Skeleton: Antiproliferative Activity against TNBC Cancer Cells and Comparison with the Acyclic Ferrocifen Series

Autor: Michael J. McGlinchey, Pascal Pigeon, Gérard Jaouen, Meral Görmen, Yong Wang, Franck Martial, Anne Vessières, Christina Gros, Siden Top

Publikováno v: European Journal of Inorganic Chemistry
European Journal of Inorganic Chemistry, Wiley-VCH Verlag, 2017, Special Issue: The Multifaceted Chemistry of Ferrocene (Cluster Issue), pp.454-465. ⟨10.1002/ejic.201601088⟩

International audience; As part of our ongoing study of the toxicity of compounds derived from 1,1-bis(4-hydroxyphenyl)-2-ferrocenylbut-1-ene, we have recently shown that closely analogous [3]ferrocenophane complexes have an in vitro toxicity level s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ce99f13a3c5fa7d43a83af7e9ae8ca
https://doi.org/10.1002/ejic.201601088