Correction: Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells

Autor: Clemens Zwergel, Michael Schnekenburger, Federica Sarno, Cecilia Battistelli, Maria Cristina Manara, Giulia Stazi, Roberta Mazzone, Rossella Fioravanti, Christina Gros, Frédéric Ausseil, Cristina Florean, Angela Nebbioso, Raffaele Strippoli, Toshikazu Ushijima, Katia Scotlandi, Marco Tripodi, Paola B. Arimondo, Lucia Altucci, Marc Diederich, Antonello Mai, Sergio Valente

Publikováno v: Clinical Epigenetics. 14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b22e2861b135099f339db55504a34a0
https://doi.org/10.1186/s13148-022-01339-y

Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity.

Autor: Dante Rotili, Domenico Tarantino, Biagina Marrocco, Christina Gros, Véronique Masson, Valérie Poughon, Fréderic Ausseil, Yanqi Chang, Donatella Labella, Sandro Cosconati, Salvatore Di Maro, Ettore Novellino, Michael Schnekenburger, Cindy Grandjenette, Celine Bouvy, Marc Diederich, Xiaodong Cheng, Paola B Arimondo, Antonello Mai

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96941 (2014)

Chemical manipulations performed on the histone H3 lysine 9 methyltransferases (G9a/GLP) inhibitor BIX-01294 afforded novel desmethoxyquinazolines able to inhibit the DNA methyltransferase DNMT3A at low micromolar levels without any significant inhib

Externí odkaz: https://doaj.org/article/281a01d650e04497b3316ad698b79eb4

Side‐Chain Effects on the 1‐(Bis‐aryl‐methylidene)‐[3]ferrocenophane Skeleton: Antiproliferative Activity against TNBC Cancer Cells and Comparison with the Acyclic Ferrocifen Series

Autor: Michael J. McGlinchey, Pascal Pigeon, Gérard Jaouen, Meral Görmen, Yong Wang, Franck Martial, Anne Vessières, Christina Gros, Siden Top

Publikováno v: European Journal of Inorganic Chemistry
European Journal of Inorganic Chemistry, Wiley-VCH Verlag, 2017, Special Issue: The Multifaceted Chemistry of Ferrocene (Cluster Issue), pp.454-465. ⟨10.1002/ejic.201601088⟩

International audience; As part of our ongoing study of the toxicity of compounds derived from 1,1-bis(4-hydroxyphenyl)-2-ferrocenylbut-1-ene, we have recently shown that closely analogous [3]ferrocenophane complexes have an in vitro toxicity level s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ce99f13a3c5fa7d43a83af7e9ae8ca
https://doi.org/10.1002/ejic.201601088

Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells

Autor: Xiaodong Cheng, Marc Diederich, Michael Schnekenburger, Christina Gros, Gilbert Kirsch, Clemens Zwergel, Yanqi Chang, Hideharu Hashimoto, Sergio Valente, Maria Tardugno, Xing Zhang, Yiwei Liu, Ettore Novellino, Antonello Mai, Donatella Labella, Cristina Florean, Sandro Cosconati, Evelina Miele, Steven Minden, Alberto Gulino, Paola B. Arimondo, Elisabetta Ferretti

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2014, 57 (3), pp.701-713. ⟨10.1021/jm4012627⟩
Journal of Medicinal Chemistry; Vol 57

DNA methyltransferases (DNMTs) are important enzymes involved in epigenetic control of gene expression and represent valuable targets in cancer chemotherapy. A number of nucleoside DNMT inhibitors (DNMTi) have been studied in cancer, including in can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e28e69f185769b4fa323a2b7414a9c
https://doi.org/10.1021/jm4012627

Design and synthesis of new non nucleoside inhibitors of DNMT3A

Autor: Ludovic Halby, Yoann Menon, Christina Gros, Alexandre Erdmann, Arnaud Samson, Paola B. Arimondo, Natacha Novosad, Nicolas Molinier, Jean-Marc Gregoire, Christophe Long, Frédéric Ausseil

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2015, 23, pp.5946-5953. ⟨10.1016/j.bmc.2015.06.066⟩

International audience; DNA methylation, an epigenetic modification regulating gene expression, is a promising target in cancer. In an effort to identify new non nucleosidic inhibitors of DNA methyltransferases, the enzymes responsible for DNA methyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5000f3afd39ae665204662c59c6e36cb
https://hal-pasteur.archives-ouvertes.fr/pasteur-03046279