Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christina F. Sandall"'
Autor:
Simone Gastaldi, Valentina Boscaro, Eleonora Gianquinto, Christina F. Sandall, Marta Giorgis, Elisabetta Marini, Federica Blua, Margherita Gallicchio, Francesca Spyrakis, Justin A. MacDonald, Massimo Bertinaria
Publikováno v:
Molecules, Vol 26, Iss 13, p 3975 (2021)
In the search for new chemical scaffolds able to afford NLRP3 inflammasome inhibitors, we used a pharmacophore-hybridization strategy by combining the structure of the acrylic acid derivative INF39 with the 1-(piperidin-4-yl)1,3-dihydro-2H-benzo[d]im
Externí odkaz:
https://doaj.org/article/3c3494cec8624421abf07d12c3ebe214
Autor:
Jaye M. Platnich, Hyunjae Chung, Arthur Lau, Christina F. Sandall, Adom Bondzi-Simpson, Huey-Miin Chen, Takanori Komada, Aaron C. Trotman-Grant, Jeremy R. Brandelli, Justin Chun, Paul L. Beck, Dana J. Philpott, Stephen E. Girardin, May Ho, Roger P. Johnson, Justin A. MacDonald, Glen D. Armstrong, Daniel A. Muruve
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1525-1536.e7 (2018)
Summary: The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways remains unclear. Shiga toxin 2 (Stx2)/LPS complex, from pathogenic enter
Externí odkaz:
https://doaj.org/article/b1fc8d30a7c34e8d876e21e962d781d8
Publikováno v:
Molecules, Vol 25, Iss 19, p 4572 (2020)
The prototypical model for NOD-like receptor (NLR) inflammasome assembly includes nucleotide-dependent activation of the NLR downstream of pathogen- or danger-associated molecular pattern (PAMP or DAMP) recognition, followed by nucleation of hetero-o
Externí odkaz:
https://doaj.org/article/e888ae0f8c2646d08ebffb1a9f941b76
The inflammasome-forming NOD-like receptor containing pyrin-3 (NLRP3) protein is a critical player in the innate immune responses to cellular danger signals. New structural data of NLRP3 provide a framework to probe the conformational impact of nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91599fe5b3e44018dd4c49cdd36453ab
https://doi.org/10.1101/2023.05.03.539258
https://doi.org/10.1101/2023.05.03.539258
Autor:
Justin A. MacDonald, Eleonora Gianquinto, Marta Giorgis, Valentina Boscaro, Francesca Spyrakis, Federica Blua, Christina F. Sandall, Margherita Gallicchio, Elisabetta Marini, Massimo Bertinaria, Simone Gastaldi
Publikováno v:
Molecules
Volume 26
Issue 13
Molecules, Vol 26, Iss 3975, p 3975 (2021)
Volume 26
Issue 13
Molecules, Vol 26, Iss 3975, p 3975 (2021)
In the search for new chemical scaffolds able to afford NLRP3 inflammasome inhibitors, we used a pharmacophore-hybridization strategy by combining the structure of the acrylic acid derivative INF39 with the 1-(piperidin-4-yl)1,3-dihydro-2H-benzo[d]im
Autor:
Kuo-Chieh Liao, Philip F. Hughes, David A. Carlson, Daniel A. Muruve, Timothy A.J. Haystead, Christina F. Sandall, Jaye M. Platnich, Annegret Ulke-Lemée, Justin A. MacDonald
Publikováno v:
Archives of Biochemistry and Biophysics. 670:104-115
The NLRP proteins are a subfamily of the NOD-like receptor (NLR) innate immune sensors that possess an ATP-binding NACHT domain. As the most well studied member, NLRP3 can initiate the assembly process of a multiprotein complex, termed the inflammaso
Autor:
Kyle L. Flannigan, Simon A. Hirota, Sridhar Mani, Daniel A. Muruve, Christina F. Sandall, Vivek Krishna Pulakazhi Venu, Grace Marie Hudson, Thomas K. H. Chang, Laurie Alston, Justin A. MacDonald
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
The pregnane X receptor (PXR) is a ligand-activated nuclear receptor that acts as a xenobiotic sensor, responding to compounds of foreign origin, including pharmaceutical compounds, environmental contaminants, and natural products, to induce transcri
Autor:
Stephen E. Girardin, Takanori Komada, Justin A. MacDonald, Huey-Miin Chen, Daniel A. Muruve, Paul L. Beck, Roger P. Johnson, Jaye M. Platnich, Adom Bondzi-Simpson, Jeremy R. Brandelli, Arthur Lau, Aaron Trotman-Grant, Hyunjae Chung, Christina F. Sandall, Glen D. Armstrong, Justin Chun, Dana J. Philpott, May Ho
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1525-1536.e7 (2018)
Summary: The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways remains unclear. Shiga toxin 2 (Stx2)/LPS complex, from pathogenic enter
Extracellular cathepsin Z signals through the α5 integrin and augments NLRP3 inflammasome activation
Autor:
Justin A. MacDonald, Catherine J. Greene, Christina F. Sandall, Neil McKenna, Rhiannon I. Campden, Jose A. Chiriboga, Robin M. Yates, Devin Aggarwal, Amy L. Warren, Corey R. Arnold
Publikováno v:
The Journal of Biological Chemistry
Respiratory silicosis is a preventable occupational disease that develops secondary to the aspiration of crystalline silicon dioxide (silica) into the lungs, activation of the NLRP3 inflammasome, and IL-1β production. Cathepsin Z has been associated
Publikováno v:
Archives of biochemistry and biophysics. 670
The pyrin domain containing Nod-like receptors (NLRPs) are a family of pattern recognition receptors known to regulate an array of immune signaling pathways. Emergent studies demonstrate the potential for regulatory control of inflammasome assembly b