Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Christina F Thobakgale"'
Autor:
Kewreshini K Naidoo, Zesuliwe B Shangase, Tabassum Rashid, Ayanda Ngubane, Nasreen Ismail, Thumbi Ndung'u, Christina F Thobakgale
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242448 (2020)
The Duffy Antigen Receptor for Chemokines (DARC)-null trait, common among persons of African descent and associated with lower absolute neutrophil counts (ANCs), may be linked to increased risk to certain infections including HIV-1 but the underlying
Externí odkaz:
https://doaj.org/article/5b80a829c5c94c42ba9e8448bbd0cd3b
Autor:
Angelique Hölzemer, Christina F Thobakgale, Camilo A Jimenez Cruz, Wilfredo F Garcia-Beltran, Jonathan M Carlson, Nienke H van Teijlingen, Jaclyn K Mann, Manjeetha Jaggernath, Seung-gu Kang, Christian Körner, Amy W Chung, Jamie L Schafer, David T Evans, Galit Alter, Bruce D Walker, Philip J Goulder, Mary Carrington, Pia Hartmann, Thomas Pertel, Ruhong Zhou, Thumbi Ndung'u, Marcus Altfeld
Publikováno v:
PLoS Medicine, Vol 12, Iss 11, p e1001900; discussion e1001900 (2015)
BackgroundViruses can evade immune surveillance, but the underlying mechanisms are insufficiently understood. Here, we sought to understand the mechanisms by which natural killer (NK) cells recognize HIV-1-infected cells and how this virus can evade
Externí odkaz:
https://doaj.org/article/fa6dc56a9531426d9574a273ad87bc21
Autor:
Danni Ramduth, Cheryl L Day, Christina F Thobakgale, Nompumelelo P Mkhwanazi, Chantal de Pierres, Sharon Reddy, Mary van der Stok, Zenele Mncube, Kriebashne Nair, Eshia S Moodley, Daniel E Kaufmann, Hendrik Streeck, Hoosen M Coovadia, Photini Kiepiela, Philip J R Goulder, Bruce D Walker
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5013 (2009)
A dominance of Gag-specific CD8+ T cell responses is significantly associated with a lower viral load in individuals with chronic, untreated clade C human immunodeficiency virus type 1 (HIV-1) infection. This association has not been investigated in
Externí odkaz:
https://doaj.org/article/ee88e71953b84f48aebb816035d8099c
Autor:
Sindiswa Nkotwana, Thumbi Ndung'u, Marcusa Altfeld, Kewreshini K. Naidoo, Maja Ziegler, Zenele Mncube, Nasreen Ismael, Philipb Goulder, Jaclyn K. Mann, Anais Chapel, Christina F. Thobakgale
Publikováno v:
AIDS. 35:151-154
HIV-1 sequence variations impact binding of inhibitory killer cell immunoglobulin-like receptors (KIRs) to human leukocyte antigen class I (HLA-I) molecules modulating natural killer cell function. HIV-1 strains encoding amino acids that mediate bind
Autor:
Zenele Mncube, Christina F. Thobakgale, Marcus Altfeld, Michael Z. Zulu, Kewreshini K. Naidoo, Manjeetha Jaggernath, Philip J. R. Goulder, Thumbi Ndung'u
Publikováno v:
AIDS Research and Human Retroviruses. 33:1205-1213
HIV-1 viremia has been shown to induce several phenotypic and functional abnormalities in natural killer (NK) cells. To assess immune defects associated with HIV viremia, we examined NK cell function, differentiation status, and phenotypic alteration
Autor:
Kewreshini K. Naidoo, Ayanda Ngubane, Pedzisai Gaza, Amber Moodley, Thumbi Ndung'u, Christina F. Thobakgale
Publikováno v:
Frontiers in immunology
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Neutrophils are well-recognized for their pathogen killing mechanisms and disorders of neutrophil count and function are associated with recurrent infections. The Duffy Antigen Receptor for Chemokines (DARC)-null genotype is predominant in sub-Sahara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20525f4f243162640624e3a9706322c1
https://hdl.handle.net/21.11116/0000-0003-8015-421.11116/0000-0003-8017-2
https://hdl.handle.net/21.11116/0000-0003-8015-421.11116/0000-0003-8017-2
Autor:
Chanson J. Brumme, Jaclyn K. Mann, Christina F. Thobakgale-Tshabalala, Emily Adland, Philip J. R. Goulder, Jake Thomas, Jonathan M. Carlson, Vanessa L. Naidoo, Mark A. Brockman, Christie Noble, Zabrina L. Brumme, Thumbi Ndung'u
Publikováno v:
Journal of Virology
In the large majority of cases, HIV infection is established by a single variant, and understanding the characteristics of successfully transmitted variants is relevant to prevention strategies. Few studies have investigated the viral determinants of
Autor:
Michael Z, Zulu, Kewreshini K, Naidoo, Zenele, Mncube, Manjeetha, Jaggernath, Philip J R, Goulder, Thumbi, Ndung'u, Marcus, Altfeld, Christina F, Thobakgale
Publikováno v:
AIDS research and human retroviruses. 33(12)
HIV-1 viremia has been shown to induce several phenotypic and functional abnormalities in natural killer (NK) cells. To assess immune defects associated with HIV viremia, we examined NK cell function, differentiation status, and phenotypic alteration
Autor:
Marcus Altfeld, Kogieleum Naidoo, Salim S. Abdool Karim, Natasha Samsunder, Kewreshini. Naidoo, Lyle R. McKinnon, Lise. Werner, Christina F. Thobakgale, Thumbi Ndung'u
Publikováno v:
Journal of Acquired Immune Deficiency Syndromes
Background Tuberculosis (TB) remains a major cause of global morbidity and mortality, especially in the context of HIV coinfection because immunity is not completely restored following antiretroviral therapy (ART). The identification of immune correl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8908a469b9b1b5a31b3cde40162d5c73
https://europepmc.org/articles/PMC5237660/
https://europepmc.org/articles/PMC5237660/
Autor:
Ellen M, Leitman, Christina F, Thobakgale, Emily, Adland, M Azim, Ansari, Jayna, Raghwani, Andrew J, Prendergast, Gareth, Tudor-Williams, Photini, Kiepiela, Joris, Hemelaar, Jacqui, Brener, Ming-Han, Tsai, Masahiko, Mori, Lynn, Riddell, Graz, Luzzi, Pieter, Jooste, Thumbi, Ndung'u, Bruce D, Walker, Oliver G, Pybus, Paul, Kellam, Vivek, Naranbhai, Philippa C, Matthews, Astrid, Gall, Philip J R, Goulder
Publikováno v:
The Journal of Experimental Medicine
A major obstacle to an HIV cure in adult infection is a viral reservoir largely composed of CTL escape mutants. Leitman et al. demonstrate that in children, but not adults, escape variant–specific CTLs are generated that can successfully “corner