Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Christina E. Gulácsy"'
Autor:
Jean M. H. van den Elsen, Hannah B. L. Jones, Omar Kassaar, Michael J Knight, Christina E. Gulácsy, Andrew G. Watts, Rachel E Woolley, Stephen A. Wells, Stuart Parsons, Elizabeth Rodriguez, Polly Phaal, Andreia Marques, Anthony Kwok, Alison Turner, John O'Hara, Christopher R. Pudney, Leo A Bowsher, Kieran Dawkins
Publikováno v:
Biochemical Journal
Among the major challenges in the development of biopharmaceuticals are structural heterogeneity and aggregation. The development of a successful therapeutic monoclonal antibody (mAb) requires both a highly active and also stable molecule. Whilst a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b7492f844b31e06c9240ca54a3446f
https://doi.org/10.1042/bcj20200580
https://doi.org/10.1042/bcj20200580
Autor:
Daniela Patinha, Dina S. Vara, Christina E. Gulácsy, Meral Celikag, Ellie Hounslea, Anuradha Tarafdar, Zach Warren, Barbara Ferreira, Lorenzo Caggiano, Giordano Pula, Maarten P. Koeners
Publikováno v:
The FASEB Journal. 34:13959-13977
Growing evidence supports a central role of NADPH oxidases (NOXs) in the regulation of platelets, which are circulating cells involved in both hemostasis and thrombosis. Here, the use of Nox1-/- and Nox1+/+ mice as experimental models of human respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6d0eef1b2a0c660f3b13d90f868c7a
https://doi.org/10.1096/fj.202001086rrr
https://doi.org/10.1096/fj.202001086rrr
Autor:
Mark A. Jepson, Ventsislav K. Valev, Christopher R. Pudney, Dragana A. M. Catici, D. Dafydd Jones, Richard M. Meade, Dominic Alibhai, Christina E. Gulácsy, Robert J. Williams, Christian Soeller, Jody M. Mason, G. Dan Pantoş
Publikováno v:
Gulácsy, C E, Meade, R, Catici, D A M, Soeller, C, Pantos, G D, Jones, D D, Alibhai, D, Jepson, M, Valev, V K, Mason, J M, Williams, R J & Pudney, C R 2019, ' Excitation-Energy-Dependent Molecular Beacon Detects Early Stage Neurotoxic Aβ Aggregates in the Presence of Cortical Neurons ', ACS Chemical Neuroscience, vol. 10, no. 3, pp. 1240-1250 . https://doi.org/10.1021/acschemneuro.8b00322
Gulácsy, C E, Meade, R, Catici, D A M, Soeller, C, Pantos, G D, Jones, D D, Alibhai, D, Jepson, M, Valev, V K, Mason, J M, Williams, R J & Pudney, C R 2019, ' Excitation-energy-dependent molecular beacon detects early stage neurotoxic Aβ aggregates in the presence of cortical neurons ', ACS Chemical Neuroscience, vol. 10, no. 3, pp. 1240-1250 . https://doi.org/10.1021/acschemneuro.8b00322
Gulácsy, C E, Meade, R, Catici, D A M, Soeller, C, Pantos, G D, Jones, D D, Alibhai, D, Jepson, M, Valev, V K, Mason, J M, Williams, R J & Pudney, C R 2019, ' Excitation-energy-dependent molecular beacon detects early stage neurotoxic Aβ aggregates in the presence of cortical neurons ', ACS Chemical Neuroscience, vol. 10, no. 3, pp. 1240-1250 . https://doi.org/10.1021/acschemneuro.8b00322
There is now crucial medical importance placed on understanding the role of early stage, subvisible protein aggregation, particularly in neurodegenerative disease. While there are strategies for detecting such aggregates in vitro, there is no approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1107a4a1cddef979754a934bc8eae65c
Autor:
Paul R. Raithby, Alexander T. Murray, Jonathan D. Challinor, Christopher R. Pudney, Christina E. Gulácsy, David R. Carbery, Matthew P. John, Lauren E. Hatcher, Cristina Lujan
Publikováno v:
Organicbiomolecular chemistry. 14(15)
The formation and chemistry of flavin–indole charge transfer (CT) complexes has been studied using a model cationic flavin. The ability to form a CT complex is sensitive to indole structure as gauged by spectroscopic, kinetics and crystallographic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4f41d8ddbd5e477fc3315e3f548449
https://pubmed.ncbi.nlm.nih.gov/27005963
https://pubmed.ncbi.nlm.nih.gov/27005963