Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Christina Demetriadou"'
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 22 (2023)
Cardiac metabolism provides effects that extend beyond the transformation of energy for the heart to operate effectively. Some metabolites also function as signaling molecules and exert transcriptional changes. Heart failure is a progressive patholog
Externí odkaz:
https://doaj.org/article/6289a5edb5a34c94a40a3cfa42848e47
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-13 (2020)
Abstract Histone proteins are decorated with numerous post-(PTMs) or co-(CTMs) translational modifications mainly on their unstructured tails, but also on their globular domain. For many decades research on histone modifications has been focused almo
Externí odkaz:
https://doaj.org/article/e8e79e4d0b1e41518759bad56a0e4157
Autor:
Luke T. Izzo, Sophie Trefely, Christina Demetriadou, Jack M. Drummond, Takuya Mizukami, Nina Kuprasertkul, Aimee T. Farria, Phuong T. T. Nguyen, Nivitha Murali, Lauren Reich, Daniel S. Kantner, Joshua Shaffer, Hayley Affronti, Alessandro Carrer, Andrew Andrews, Brian C. Capell, Nathaniel W. Snyder, Kathryn E. Wellen
Publikováno v:
Science Advances. 9
The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear-cytoplasmic compartment are citrate and acetate, which are processed to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7356994fc12704f2e3379bbefe59fadb
https://doi.org/10.1126/sciadv.adf0115
https://doi.org/10.1126/sciadv.adf0115
Autor:
Luke Izzo, Sophie Trefely, Christina Demetriadou, Jack Drummond, Takuya Mizukami, Nina Kuprasertkul, Aimee Farria, Phuong Nguyen, Lauren Reich, Joshua Shaffer, Hayley Affronti, Alessandro Carrer, Andrew Andrews, Brian C. Capell, Nathaniel W. Snyder, Kathryn E. Wellen
Acetyl-CoA is a central metabolite used for lipid synthesis in the cytosol and histone acetylation in the nucleus, among other pathways. The two major precursors to acetyl-CoA in the nuclear-cytoplasmic compartment are citrate and acetate, which are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7cb9f65bbb97cde466a9bb33bdb9926
https://doi.org/10.1101/2022.09.24.509197
https://doi.org/10.1101/2022.09.24.509197
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-13 (2020)
Epigenetics & Chromatin
Epigenetics & Chromatin
Histone proteins are decorated with numerous post-(PTMs) or co-(CTMs) translational modifications mainly on their unstructured tails, but also on their globular domain. For many decades research on histone modifications has been focused almost solely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c2b17fce434b15b3d1a46d44fd4464
http://link.springer.com/article/10.1186/s13072-020-00352-w
http://link.springer.com/article/10.1186/s13072-020-00352-w
Autor:
Swati Parekh, Anastasia Raoukka, Christina Demetriadou, Panagiotis Papageorgis, Costas Koufaris, Paris A. Skourides, Antonis Kirmizis, Evelina Charidemou, Peter Tessarz, Christina Michael, Constantine Mylonas
Publikováno v:
Oncogene
Aberrant function of epigenetic modifiers plays an important role not only in the progression of cancer but also the development of drug resistance. N-alpha-acetyltransferase 40 (NAA40) is a highly specific epigenetic enzyme catalyzing the transfer o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819cce3d3a39e892e3858c67312fc9cf
https://hdl.handle.net/21.11116/0000-000A-FA9B-E
https://hdl.handle.net/21.11116/0000-000A-FA9B-E
Publikováno v:
Critical Reviews™ in Oncogenesis. 22:195-218
Histone acetyltransferases (HATs) catalyzing N-epsilon-lysine or N-alpha-terminal acetylation on histone and non-histone substrates are important epigenetic regulators controlling gene expression and chromatin structure. Deregulation of these enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1487606ad23bd507d12e2b42049e6f
https://doi.org/10.1615/critrevoncog.2017024506
https://doi.org/10.1615/critrevoncog.2017024506