Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Christina D. Orrù"'
Autor:
Sara Hall, Christina D. Orrù, Geidy E. Serrano, Douglas Galasko, Andrew G. Hughson, Bradley R. Groveman, Charles H. Adler, Thomas G. Beach, Byron Caughey, Oskar Hansson
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-13 (2022)
Abstract Currently, there is a need for diagnostic markers in Lewy body disorders (LBD). α-synuclein (αSyn) RT-QuIC has emerged as a promising assay to detect misfolded αSyn in clinically or neuropathologically established patients with various sy
Externí odkaz:
https://doaj.org/article/e768a7c40134455eb2abe96a729c8027
Autor:
Simote T. Foliaki, Benjamin Schwarz, Bradley R. Groveman, Ryan O. Walters, Natalia C. Ferreira, Christina D. Orrù, Anna Smith, Aleksandar Wood, Olivia M. Schmit, Phoebe Freitag, Jue Yuan, Wenquan Zou, Catharine M. Bosio, James A. Carroll, Cathryn L. Haigh
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-23 (2021)
Abstract The neuro-physiological properties of individuals with genetic pre-disposition to neurological disorders are largely unknown. Here we aimed to explore these properties using cerebral organoids (COs) derived from fibroblasts of individuals wi
Externí odkaz:
https://doaj.org/article/6bd0dd66c2cd46cbb517d6bd6b03291d
Autor:
Christina D. Orrù, Thong C. Ma, Andrew G. Hughson, Bradley R. Groveman, Ankit Srivastava, Douglas Galasko, Rachel Angers, Patrick Downey, Karen Crawford, Samantha J. Hutten, Un Jung Kang, Byron Caughey
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 2, Pp 374-384 (2021)
Abstract Background Assays that specifically measure α‐synuclein seeding activity in biological fluids could revolutionize the diagnosis of Parkinson’s disease. Recent improvements in α‐synuclein real‐time quaking‐induced conversion assay
Externí odkaz:
https://doaj.org/article/65c3405b7b8b4e7b97f6df54b65d2358
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Prion diseases, synucleinopathies and tauopathies are neurodegenerative disorders characterized by deposition of abnormal protein aggregates in brain and other tissues. These aggregates consist of misfolded forms of prion, α-synuclein (αSyn), or ta
Externí odkaz:
https://doaj.org/article/5df5f6ef9a154dabb2b6c3d09bddb2ed
Autor:
Bradley R. Groveman, Christina D. Orrù, Andrew G. Hughson, Lynne D. Raymond, Gianluigi Zanusso, Bernardino Ghetti, Katrina J. Campbell, Jiri Safar, Douglas Galasko, Byron Caughey
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-10 (2018)
Abstract The diagnosis and treatment of synucleinopathies such as Parkinson disease and dementia with Lewy bodies would be aided by the availability of assays for the pathogenic disease-associated forms of α-synuclein (αSynD) that are sufficiently
Externí odkaz:
https://doaj.org/article/0d9bd34d07954635a1bb8e7f7cbb63e7
Autor:
Bradley R. Groveman, Christina D. Orrù, Andrew G. Hughson, Lynne D. Raymond, Gianluigi Zanusso, Bernardino Ghetti, Katrina J. Campbell, Jiri Safar, Douglas Galasko, Byron Caughey
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-2 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/d8d3b2642583429faa27361600113b29
Autor:
Christina D. Orrù, Katrin Soldau, Christian Cordano, Jorge Llibre-Guerra, Ari J. Green, Henry Sanchez, Bradley R. Groveman, Steven D. Edland, Jiri G. Safar, Jonathan H. Lin, Byron Caughey, Michael D. Geschwind, Christina J. Sigurdson
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common prion disease in humans and has been iatrogenically transmitted through corneal graft transplantation. Approximately 40% of sCJD patients develop visual or oculomotor symptoms and
Externí odkaz:
https://doaj.org/article/5703229a19df4bc7bb1051cfb6550757
Publikováno v:
Prions and Diseases ISBN: 9783031205644
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45db0c5b8e87b33849d9eac8bb873568
https://doi.org/10.1007/978-3-031-20565-1_30
https://doi.org/10.1007/978-3-031-20565-1_30
Autor:
Tze How Mok, Akin Nihat, Nour Majbour, Danielle Sequeira, Leah Holm-Mercer, Thomas Coysh, Lee Darwent, Mark Batchelor, Bradley R Groveman, Christina D Orrù, Andrew G Hughson, Amanda Heslegrave, Rhiannon Laban, Elena Veleva, Ross W Paterson, Ashvini Keshavan, Jonathan Schott, Imogen J Swift, Carolin Heller, Jonathan D Rohrer, Alexander Gerhard, Christopher Butler, James B Rowe, Mario Masellis, Miles Chapman, Michael P Lunn, Jan Bieschke, Graham Jackson, Henrik Zetterberg, Byron Caughey, Peter Rudge, John Collinge, Simon Mead
Human prion diseases are remarkable for long incubation times followed by typically rapid clinical decline. Seed amplification assays and neurodegeneration biofluid biomarkers are remarkably useful in the clinical phase, but their potential to predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da3aac789cb837499652c75f72d24073
https://doi.org/10.1101/2022.10.30.22281644
https://doi.org/10.1101/2022.10.30.22281644
Autor:
Simone Baiardi, Niccolò Candelise, Anna Ladogana, Sabina Capellari, Byron Caughey, Elena Antelmi, Giovanna Calandra-Buonaura, Piero Parchi, Giuseppe Plazzi, Giulia Giannini, Andrew G. Hughson, Marcello Rossi, Christina D. Orrù, Angela Mammana, Pietro Cortelli
Publikováno v:
Acta Neuropathologica
The clinical diagnosis of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), is challenging, especially at an early disease stage, due to the heterogeneous and often non-specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b80fa0254b4c194196dedd48c99cbc
https://doi.org/10.1007/s00401-020-02160-8
https://doi.org/10.1007/s00401-020-02160-8