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pro vyhledávání: '"Christina D. Brown-Marshall"'
Autor:
Christina D. Brown-Marshall, Adrienne R. Diebold, Michael L. Neidig, Graham R. Moran, Edward I. Solomon, June M. Brownlee
Publikováno v:
Journal of the American Chemical Society. 133:18148-18160
The α-keto acid-dependent dioxygenases are a major subgroup within the O(2)-activating mononuclear nonheme iron enzymes. For these enzymes, the resting ferrous, the substrate plus cofactor-bound ferrous, and the Fe(IV)═O states of the reaction hav
Publikováno v:
Biochemistry. 49:1176-1182
Isopenicillin N synthase (IPNS) can have both oxidase and oxygenase activity depending on the substrate. For the native substrate, ACV, oxidase activity exists; however, for the substrate analogue ACOV, which lacks an amide nitrogen, IPNS exhibits ox