Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Christina Coughlan"'
Autor:
Allison L. B. Shapiro, Christina Coughlan, Brianne M. Bettcher, Meghan E. Pauley, Jeongchul Kim, Petter Bjornstad, Benjamin Rajic, Jennifer Truong, Christopher Bell, Ye Ji Choi, Keenan A. Walker, Huntington Potter, Angela D. Liese, Dana Dabelea, Christopher T. Whitlow
Publikováno v:
Endocrines, Vol 5, Iss 2, Pp 197-213 (2024)
Adult-onset diabetes increases one’s risk of neurodegenerative disease including Alzheimer’s disease (AD); however, the risk associated with youth-onset diabetes (Y-DM) remains underexplored. We quantified plasma biomarkers of neurodegeneration a
Externí odkaz:
https://doaj.org/article/1b500686e7d74e3cb3f6f79643b1424a
Autor:
Brianne M. Bettcher, Dan Lopez Paniagua, Yue Wang, Brice V. McConnell, Christina Coughlan, Tara C. Carlisle, Ashesh A. Thaker, William Lippitt, Christopher M. Filley, Victoria S. Pelak, Allison L.B. Shapiro, Kate S. Heffernan, Huntington Potter, Adriana Solano, Jada Boyd, Nichole E. Carlson
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 40, Iss , Pp 100834- (2024)
Background: Plasma glial fibrillary acidic protein (GFAP), an astrocytic biomarker, has previously been linked with Alzheimer's disease (AD) status, amyloid levels, and memory performance in older adults. The neuroanatomical pathways by which astrogl
Externí odkaz:
https://doaj.org/article/35ee481cfc76470695fd6754086cd15d
Autor:
Christina Coughlan, Jared Lindenberger, Jeffrey G. Jacot, Noah R. Johnson, Paige Anton, Shaun Bevers, Robb Welty, Michael W. Graner, Huntington Potter
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3703 (2024)
Alzheimer’s disease (AD) is the fifth leading cause of death among adults aged 65 and older, yet the onset and progression of the disease is poorly understood. What is known is that the presence of amyloid, particularly polymerized Aβ42, defines w
Externí odkaz:
https://doaj.org/article/377963c4b07f4f4d805feee00166b7e7
Autor:
Noah R. Johnson, Athena C.-J. Wang, Christina Coughlan, Stefan Sillau, Esteban Lucero, Lisa Viltz, Neil Markham, Cody Allen, A. Ranjitha Dhanasekaran, Heidi J. Chial, Huntington Potter
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-23 (2022)
Abstract Background The apolipoprotein E (APOE) ε4 allele confers the strongest risk for late-onset Alzheimer’s disease (AD) besides age itself, but the mechanisms underlying this risk are debated. One hypothesis supported by evidence from multipl
Externí odkaz:
https://doaj.org/article/208104f13e554508873550b7386d02e9
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
ObjectiveAdults with cerebral palsy (CP) often have impaired cognitive functions. CP also has deteriorations in multiple quality-of-life (QoL) domains. The bio-psycho-social health psychology model posits that biological factor interacts with social
Externí odkaz:
https://doaj.org/article/6ef6504aea5a4e30bd955f98b203f791
Autor:
Md. Mahiuddin Ahmed, Athena Ching-Jung Wang, Mihret Elos, Heidi J. Chial, Stefan Sillau, D. Adriana Solano, Christina Coughlan, Leila Aghili, Paige Anton, Neil Markham, Vanesa Adame, Katheleen J. Gardiner, Timothy D. Boyd, Huntington Potter
Publikováno v:
Neurobiology of Disease, Vol 168, Iss , Pp 105694- (2022)
Down syndrome (DS) is characterized by chronic neuroinflammation, peripheral inflammation, astrogliosis, imbalanced excitatory/inhibitory neuronal function, and cognitive deficits in both humans and mouse models. Suppression of inflammation has been
Externí odkaz:
https://doaj.org/article/afca7c18fdef4a53a47db47b60243c02
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT Enterovirus D68 (EV-D68) is an emerging pathogen which causes respiratory disease and is associated with an acute flaccid myelitis that predominately affects children. EV-D68 can infect motor neurons, causing cell death and a loss of motor c
Externí odkaz:
https://doaj.org/article/a0c1c1fab65542bcb3c4c01c17ff64a9
Autor:
Miguel Flores‐Bellver, Jason Mighty, Silvia Aparicio‐Domingo, Kang V. Li, Cui Shi, Jing Zhou, Hannah Cobb, Patrick McGrath, German Michelis, Patricia Lenhart, Ganna Bilousova, Søren Heissel, Michael J. Rudy, Christina Coughlan, Andrew E. Goodspeed, S. Patricia Becerra, Stephen Redenti, M. Valeria Canto‐Soler
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 13, Pp n/a-n/a (2021)
Abstract Age‐related macular degeneration (AMD) is a leading cause of blindness worldwide. Drusen are key contributors to the etiology of AMD and the ability to modulate drusen biogenesis could lead to therapeutic strategies to slow or halt AMD pro
Externí odkaz:
https://doaj.org/article/f4461325f8d6451f97d6779225925a12
Autor:
Md. Mahiuddin Ahmed, Noah R. Johnson, Timothy D. Boyd, Christina Coughlan, Heidi J. Chial, Huntington Potter
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Innate immune system activation and inflammation are associated with and may contribute to clinical outcomes in people with Down syndrome (DS), neurodegenerative diseases such as Alzheimer’s disease (AD), and normal aging. In addition to serving as
Externí odkaz:
https://doaj.org/article/52ccc50c35594f67b486d1714318141b
Autor:
Wenbo Zhou, Daniel Lovasz, Zoë Zizzo, Qianbin He, Christina Coughlan, Robert G. Kowalski, Peter G. E. Kennedy, Arin N. Graner, Kevin O. Lillehei, D. Ryan Ormond, A. Samy Youssef, Michael W. Graner, Xiaoli Yu
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2718 (2022)
Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. Extracellular vesicles (EVs) released by tumor cells play a critical role in cellular communication in the tumor microenvironment promoting tumor progression and invasion. We h
Externí odkaz:
https://doaj.org/article/b53e63a22e594d2e9d6b55cbb8a35846