Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Christina Cherian"'
Autor:
Ping Yee Billie Au, Setareh Ashtiani, Marina Kerr, Juan Pablo Appendino, Paolo Federico, Karl Martin Klein, Aneal Khan, Christina Cherian, Christine P. Molnar
Publikováno v:
Journal of Neurology. 269:2162-2171
Pathogenic variants in KCNT1 have been associated with severe forms of epilepsy, typically sleep-related hypermotor epilepsy or epilepsy of infancy with migrating focal seizures. To show that pathogenic variants in KCNT1 can be associated with mild e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::018153fafa4da066876ada6bb4a39fd0
https://doi.org/10.1007/s00415-021-10808-y
https://doi.org/10.1007/s00415-021-10808-y
Autor:
Christina, Cherian, Juan P, Appendino, Setareh, Ashtiani, Paolo, Federico, Christine P, Molnar, Marina, Kerr, Aneal, Khan, Ping Yee Billie, Au, Karl Martin, Klein
Publikováno v:
Journal of neurology. 269(4)
Pathogenic variants in KCNT1 have been associated with severe forms of epilepsy, typically sleep-related hypermotor epilepsy or epilepsy of infancy with migrating focal seizures. To show that pathogenic variants in KCNT1 can be associated with mild e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1092ff48c3368b068467e605a2dc422b
https://pubmed.ncbi.nlm.nih.gov/34537872
https://pubmed.ncbi.nlm.nih.gov/34537872
Autor:
Aleem Gangjee, Manasa P. Ravindra, Shermaine Mitchell-Ryan, Larry H. Matherly, Steven Orr, Eric C. Hales, Sudhir Raghavan, Christina Cherian, Zhanjun Hou, Yiqiang Wang
Publikováno v:
Journal of Medicinal Chemistry. 56:10016-10032
We synthesized 5-substituted pyrrolo[2,3-d]pyrimidine antifolates (compounds 5-10) with one-to-six bridge carbons and a benozyl ring in the side chain as antitumor agents. Compound 8 with a 4-carbon bridge was the most active analogue and potently in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04814daf7076b8793492dfa4f0b9b0fe
https://doi.org/10.1021/jm401328u
https://doi.org/10.1021/jm401328u
Autor:
Aleem Gangjee, Sita Kugel Desmoulin, Lisa Polin, Larry H. Matherly, Lei Wang, Christina Cherian, Kathryn White, Juiwanna Kushner, Zhanjun Hou, Mark Stout
Publikováno v:
Cancer Chemotherapy and Pharmacology. 71:999-1011
The 5-substituted pyrrolo[2,3-d]pyrimidine antifolate pemetrexed (Pmx) is an active agent for malignant pleural mesothelioma (MPM). Pmx is transported into MPM cells by the reduced folate carrier (RFC) and proton-coupled folate transporter (PCFT). We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169fa90d846c7005f23e839fd241eb75
https://doi.org/10.1007/s00280-013-2094-0
https://doi.org/10.1007/s00280-013-2094-0
Autor:
Joel R. Morgan, Lei Wang, Aleem Gangjee, Stuart J. Kahn, Aaron D. Schuler, Breck Thrash, Dean Y. Maeda, Larry H. Matherly, Alan Menter, Christina Cherian, John A. Zebala
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 342:696-708
N-[4-[[(2,4-diamino-6-pterdinyl)methyl]amino]benzoyl]-l/d-glutamic acid (l/d-AMT) is an investigational drug in phase 1 clinical development that consists of the l-and d-enantiomers of aminopterin (AMT). l/d-AMT is obtained from a novel process for m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e631960def7924fbacc3f7353fb09d9b
https://doi.org/10.1124/jpet.112.195479
https://doi.org/10.1124/jpet.112.195479
Autor:
Sukhesh Sudan, David W. Hines, Christina Cherian, Teena Chopra, George Glenn, Ellie J. C. Goldstein
Publikováno v:
Open Forum Infectious Diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69202eb22447e790922d46273224ac19
http://europepmc.org/articles/PMC5127387
http://europepmc.org/articles/PMC5127387
Autor:
Sita Kugel Desmoulin, Aleem Gangjee, Christina Cherian, Juiwanna Kushner, Eric C. Hales, Larry H. Matherly, Lisa Polin, Lei Wang, Kathryn White, Zhanjun Hou, Mark Stout
Publikováno v:
Molecular Pharmacology. 80:1096-1107
The proton-coupled folate transporter (PCFT) is a proton-folate symporter with an acidic pH optimum. By real-time reverse transcription-polymerase chain reaction, PCFT was expressed in the majority of 53 human tumor cell lines, with the highest level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf1855c3ef246d33626cf1627a5e298
https://doi.org/10.1124/mol.111.073833
https://doi.org/10.1124/mol.111.073833
Publikováno v:
Journal of Biological Chemistry. 285:4732-4740
The reduced folate carrier (RFC) is the major transport system for folates in mammals. We previously demonstrated the existence of human RFC (hRFC) homo-oligomers and established the importance of these higher order structures to intracellular traffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56eb41352bccf4e7d4bd5af4711c7ed8
https://doi.org/10.1074/jbc.m109.086033
https://doi.org/10.1074/jbc.m109.086033
Autor:
A Larson Gedman, Katherine M. LaFiura, Christina L. Haska, Stephen B. Linda, Jeffrey W. Taub, S Kugel Desmoulin, Meenakshi Devidas, Larry H. Matherly, Yubin Ge, Qing Chen, Christina Cherian
Publikováno v:
Leukemia
We explored the impact of mutations in the NOTCH1, FBW7 and PTEN genes on prognosis and downstream signaling in a well-defined cohort of 47 patients with pediatric T-cell acute lymphoblastic leukemia (T-ALL). In T-ALL lymphoblasts, we identified high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c131a4825c60abdc8b362c92bf12d93a
http://europepmc.org/articles/PMC2726275
http://europepmc.org/articles/PMC2726275
Autor:
Zhanjun Hou, Christina Cherian, Aleem Gangjee, Steven Buck, Larry H. Matherly, Yijun Deng, Yiqiang Wang
Publikováno v:
Journal of Medicinal Chemistry. 51:5052-5063
6-Substituted classical pyrrolo[2,3-d]pyrimidine antifolates with a three- to six-carbon bridge between the heterocycle and the benzoyl-L-glutamate (compounds 2-5, respectively) were synthesized starting from methyl 4-formylbenzoate and a Wittig reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b417fae4e428a9162cd93f604ad121
https://doi.org/10.1021/jm8003366
https://doi.org/10.1021/jm8003366