Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christina C. Spevak"'
Autor:
William S. Eng, Christina C. Spevak, Caryn J. Ha, Gaëlle H. Martin, Harold Elias, Vinagolu K. Rajasekhar, Carolien M. Woolthuis, Christopher Y. Park, Lavanya Kannan, Amanda Ernlund, Guangjie Zhao, Shanmugapriya Selvaraj, Robert J. Schneider, Mohamed A.E. Ali
Publikováno v:
Cell Stem Cell
Cell stem cell, 26(5), 755-765.e7. CELL PRESS
Cell stem cell, 26(5), 755-765.e7. CELL PRESS
Hematopoietic stem cells (HSCs) require highly regulated rates of protein synthesis, but it is unclear if they or lineage-committed progenitors preferentially recruit transcripts to translating ribosomes. We utilized polysome profiling, RNA sequencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e920664658a771fd7e99fc26e3dcdaae
https://europepmc.org/articles/PMC9435590/
https://europepmc.org/articles/PMC9435590/
Publikováno v:
JNCI: Journal of the National Cancer Institute.
Autor:
Christopher Y. Park, Amanda Ernlund, Gaëlle H. Martin, Lavanya Kannan, Robert J. Schneider, Carolien M. Woolthuis, Harold Elias, Vinagolu K. Rajasekhar, William S. Eng, Christina C. Spevak, Shanmugapriya Selvaraj
Publikováno v:
Molecular Cancer Research. 18:PR06-PR06
Acute myeloid leukemia (AML) is a clonal disorder of hematopoiesis originating in hematopoietic/stem progenitor cells characterized by impaired differentiation and the accumulation of immature blasts in the bone marrow. While genetic, transcriptional
Autor:
Shanmugapriya Selvaraj, William S. Eng, Gaëlle H. Martin, Guangjie Zhao, Mohamed A.E. Ali, Christopher Y. Park, Carolien M. Woolthuis, Amanda Ernlund, Harold Elias, Vinagolu K. Rajasekhar, Lavanya Kannan, Robert J. Schneider, Christina C. Spevak
Publikováno v:
Blood. 134:1180-1180
Prior studies in numerous biological systems have shown that alterations in mRNA expression frequently fail to predict changes in protein expression. This may be due to many regulatory mechanisms that occur post-transcriptionally including mRNA recru
Autor:
Christina C. Spevak, Lilly Y.W. Bourguignon, Gabriel Wong, Christine Earle, Katherine C. Krueger
Publikováno v:
Oncogene
Oncogene, vol 31, iss 2
Oncogene, vol 31, iss 2
MicroRNAs are often associated with the pathogenesis of many cancers including Head and Neck Squamous Cell Carcinoma (HNSCC). In particular, microRNA-21 (miR-21) appears to play a critical role in tumor cell survival, chemoresistance and HNSCC progre
Publikováno v:
Journal of Biological Chemistry. 285:40933-40942
The 5′ regions of eukaryotic mRNAs often contain upstream open reading frames (uORFs). The Neurospora crassa arg-2 uORF encodes the 24-residue arginine attenuator peptide (AAP). This regulatory uORF-encoded peptide, which is evolutionarily conserve
Autor:
Lilly Y.W. Bourguignon, Gabriel Wong, Katherine C. Krueger, Christine Earle, Christina C. Spevak
Publikováno v:
Journal of Biological Chemistry. 285:36721-36735
Dysregulation of microRNAs is observed in many cancers, including breast cancer. In particular, miR-10b appears to play an important role in tumor cell invasion and breast cancer progression. In this study, we investigated hyaluronan (HA)-induced CD4
Publikováno v:
Fungal Genetics and Biology. 44:93-104
The Neurospora crassa arg-2 and the Saccharomyces cerevisiae ortholog CPA1 encode the arginine-specific carbamoyl-phosphate synthetase (CPS-A) small subunit. Arginine decreases synthesis of this subunit through the action of a 5' upstream open readin
Publikováno v:
Biochemical and Biophysical Research Communications. 350:834-841
The her-2 (neu, erbB-2) oncogene encodes a 185-kDa transmembrane receptor tyrosine kinase. HER2 overexpression occurs in numerous primary human tumors and contributes to 25–30% of breast and ovarian carcinomas. Synthesis of HER2 is controlled in pa
Autor:
Toshitaka Kumagai, Kay Vienken, Li-Jun Ma, Toshihiro Tanaka, Christina C. Spevak, Paul S. Dyer, Mark L. Farman, Jerzy Jurka, David B. Archer, Claudio Scazzocchio, Christiane Bouchier, Miguel A. Peñalva, Gerhard H. Braus, John H. Doonan, Arnab Pain, Kiyoshi Asai, Eric U. Selker, Reinhard Fischer, James E. Galagan, Seth Purcell, William C. Nierman, Oliver W. Draht, Michelle Momany, Jennifer R. Wortman, Deborah Bell-Pedersen, Bruce W. Birren, Berl R. Oakley, Christina A. Cuomo, David W. Denning, Michael J. Hynes, Jonathan Butler, Su-In Lee, John Clutterbuck, Jae-Hyuk Yu, Christophe d'Enfert, Vladimir V. Kapitonov, Steve Harris, Gustavo H. Goldman, Masayuki Machida, Serafim Batzoglou, Sarah E. Calvo, Mathieu Paoletti, Bruce L. Miller, Matthew S. Sachs, Mark X. Caddick, Silke Busch, Meray Baştürkmen, Michael Freitag, Sam Griffiths-Jones, Stephen A. Osmani
Publikováno v:
Nature
Nature, Nature Publishing Group, 2005, 438 (7071), pp.1105-1115. ⟨10.1038/nature04341⟩
Nature, 2005, 438 (7071), pp.1105-1115. ⟨10.1038/nature04341⟩
Nature, Nature Publishing Group, 2005, 438 (7071), pp.1105-1115. ⟨10.1038/nature04341⟩
Nature, 2005, 438 (7071), pp.1105-1115. ⟨10.1038/nature04341⟩
International audience; The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution. Here we report the genome sequence of the model organism Aspergillus nidulans, and a comparative study with Aspergillus