Neutrophil-derived Activin-A moderates their pro-NETotic activity and attenuates collateral tissue damage caused by Influenza A virus infection

Autor: Georgios Divolis, Evgenia Synolaki, Athanasia Doulou, Ariana Gavriil, Christina C. Giannouli, Anastasia Apostolidou, Martyn L. Foster, Martin M. Matzuk, Panagiotis Skendros, Ioanna-Evdokia Galani, Paschalis Sideras

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundPre-neutrophils, while developing in the bone marrow, transcribe the Inhba gene and synthesize Activin-A protein, which they store and release at the earliest stage of their activation in the periphery. However, the role of neutrophil-deriv

Externí odkaz: https://doaj.org/article/cb18a5bdb9a14639863030d911714e67

TGF-β regulates differentially the proliferation of fetal and adult human skin fibroblasts via the activation of PKA and the autocrine action of FGF-2

Autor: Christina C. Giannouli, Dimitris Kletsas

Publikováno v: Cellular Signalling. 18:1417-1429

Transforming growth factor-beta (TGF-beta) is a potent regulator of cell proliferation; interestingly its action is clearly cell type-dependent. In particular, it inhibits epithelial and endothelial cells' proliferation, while its action on many mese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b65afabfd4c1d8ec6ecc1d50f0fcd2
https://doi.org/10.1016/j.cellsig.2005.11.002

Compromise in mRNA processing machinery in senescent human fibroblasts: implications for a novel potential role of Phospho-ATR (ser428)

Autor: Dimitris Kletsas, Christina C. Giannouli, George Panayotou, Panagiotis Chandris

Publikováno v: Biogerontology. 11(4)

Ataxia-Telangiectasia and Rad3 related kinase (ATR) is a major gatekeeper of genomic stability and has been the subject of exhaustive study in the context of cell cycle progression and senescence as a DNA damage-induced response. Conditional knockout

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca598be02ee7e4288c022335c39911b5
https://pubmed.ncbi.nlm.nih.gov/20084458

Specific myeloid signatures in peripheral blood differentiate active and rare clinical phenotypes of multiple sclerosis.

Autor: Vakrakou AG; Demyelinating Diseases Unit, 1st Department of Neurology, School of Medicine, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.; Department of Neuropathology, University of Göttingen Medical Center, Göttingen, Germany., Paschalidis N; Mass Cytometry-CyTOF Laboratory, Center for Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Pavlos E; Center for Clinical Research, Experimental Surgery and Translational Research Biomedical Research Foundation of the Academy of Athens, Athens, Greece.; Division of Basic Sciences, University of Crete Medical School, Heraklion, Greece., Giannouli C; Center for Clinical Research, Experimental Surgery and Translational Research Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Karathanasis D; Demyelinating Diseases Unit, 1st Department of Neurology, School of Medicine, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece., Tsipota X; Demyelinating Diseases Unit, 1st Department of Neurology, School of Medicine, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece., Velonakis G; Research Unit of Radiology, 2nd Department of Radiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Stadelmann-Nessler C; Department of Neuropathology, University of Göttingen Medical Center, Göttingen, Germany., Evangelopoulos ME; Demyelinating Diseases Unit, 1st Department of Neurology, School of Medicine, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece., Stefanis L; Demyelinating Diseases Unit, 1st Department of Neurology, School of Medicine, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece., Kilidireas C; Demyelinating Diseases Unit, 1st Department of Neurology, School of Medicine, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.; Department of Neurology, Henry Dunant Hospital Center, Athens, Greece.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Jan 25; Vol. 14, pp. 1071623. Date of Electronic Publication: 2023 Jan 25 (Print Publication: 2023).

Fusion of a tumour-associated antigen to HIV-1 Tat improves protein-based immunotherapy of cancer.

Autor: Giannouli C; Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles, Gosselies, Belgium., Brulet JM, Gesché F, Rappaport J, Burny A, Leo O, Hallez S

Publikováno v: Anticancer research [Anticancer Res] 2003 Jul-Aug; Vol. 23 (4), pp. 3523-31.