Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Christina B Young"'
Autor:
Melanie J. Plastini, Carla Abdelnour, Christina B. Young, Edward N. Wilson, Marian Shahid‐Besanti, Jennifer Lamoureux, Katrin I. Andreasson, Geoffrey A. Kerchner, Thomas J. Montine, Victor W. Henderson, Kathleen L. Poston
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 5, Pp 1197-1210 (2024)
Abstract Objective More than half of neurodegenerative disease patients have multiple pathologies at autopsy; however, most receive one diagnosis during life. We used the α‐synuclein seed amplification assay (αSyn‐SAA) and CSF biomarkers for am
Externí odkaz:
https://doaj.org/article/340d601fd43e42beb69b9417cf089816
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 4, Pp n/a-n/a (2023)
Abstract INTRODUCTION The National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) neuropsychological battery is being used to track cognition in participants across the country, but it is unknown if scores obtained through remote admin
Externí odkaz:
https://doaj.org/article/9fda87c2dea14aa7b6df9e7727f18d29
Autor:
Christina B. Young, Emily Johns, Gabriel Kennedy, Michael E. Belloy, Philip S. Insel, Michael D. Greicius, Reisa A. Sperling, Keith A. Johnson, Kathleen L. Poston, Elizabeth C. Mormino, for the Alzheimer’s Disease Neuroimaging Initiative, the A4 Study Team
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-14 (2023)
Abstract Background APOE variants are strongly associated with abnormal amyloid aggregation and additional direct effects of APOE on tau aggregation are reported in animal and human cell models. The degree to which these effects are present in humans
Externí odkaz:
https://doaj.org/article/3bee54045fa448f4900aab27548666cc
Autor:
Edward N. Wilson, Christina B. Young, Javier Ramos Benitez, Michelle S. Swarovski, Igor Feinstein, Manu Vandijck, Yann Le Guen, Nandita M. Kasireddy, Marian Shahid, Nicole K. Corso, Qian Wang, Gabriel Kennedy, Alexandra N. Trelle, Betty Lind, Divya Channappa, Malia Belnap, Veronica Ramirez, Irina Skylar-Scott, Kyan Younes, Maya V. Yutsis, Nathalie Le Bastard, Joseph F. Quinn, Christopher H. van Dyck, Angus Nairn, Carolyn A. Fredericks, Lu Tian, Geoffrey A. Kerchner, Thomas J. Montine, Sharon J. Sha, Guido Davidzon, Victor W. Henderson, Frank M. Longo, Michael D. Greicius, Anthony D. Wagner, Tony Wyss-Coray, Kathleen L. Poston, Elizabeth C. Mormino, Katrin I. Andreasson
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)
Abstract Background The recent promise of disease-modifying therapies for Alzheimer’s disease (AD) has reinforced the need for accurate biomarkers for early disease detection, diagnosis and treatment monitoring. Advances in the development of novel
Externí odkaz:
https://doaj.org/article/a7c72b7b806e4d5f9c4b0862e6246e4f
Autor:
Christina B. Young, Elizabeth C. Mormino, Kathleen L. Poston, Keith A. Johnson, Dorene M. Rentz, Reisa A. Sperling, Kathryn V. Papp
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract Scalable cognitive paradigms that provide metrics such as the Computerized Cognitive Composite (C3) may be sensitive enough to relate to Alzheimer's disease biomarkers in the preclinical clinically unimpaired (CU) stage. We examined CU older
Externí odkaz:
https://doaj.org/article/daa1b83c892e407bb6e6d084a5f8568d
Autor:
Katherine S. F. Damme, Lauren B. Alloy, Nicholas J. Kelley, Ann Carroll, Christina B. Young, Jason Chein, Tommy H. Ng, Madison K. Titone, Corinne P. Bart, Robin Nusslock
Publikováno v:
JCPP Advances, Vol 2, Iss 1, Pp n/a-n/a (2022)
Abstract Objective Elevated sensitivity to rewards prospectively predicts Bipolar Spectrum Disorder (BSD) onset; however, it is unclear whether volumetric abnormalities also reflect BSD risk. BSDs emerge when critical neurodevelopment in frontal and
Externí odkaz:
https://doaj.org/article/655c948645624125b91bd37edab8284f
Autor:
Christina B. Young, Susan M. Landau, Theresa M. Harrison, Kathleen L. Poston, Elizabeth C. Mormino
Publikováno v:
NeuroImage, Vol 243, Iss , Pp 118553- (2021)
Tau PET has allowed for critical insights into in vivo patterns of tau accumulation and change in individuals early in the Alzheimer's disease (AD) continuum. A key methodological step in tau PET analyses is the selection of a reference region, but t
Externí odkaz:
https://doaj.org/article/a75fe8eccb224803b4829ec4c0a73e8a
Autor:
Andrea Sturchio, Alok K. Dwivedi, Christina B. Young, Tarja Malm, Luca Marsili, Jennifer S. Sharma, Abhimanyu Mahajan, Emily J. Hill, Samir EL Andaloussi, Kathleen L. Poston, Fredric P. Manfredsson, Lon S. Schneider, Kariem Ezzat, Alberto J. Espay
Publikováno v:
EClinicalMedicine, Vol 38, Iss , Pp 100988- (2021)
Background: Brain amyloidosis does not invariably predict dementia. We hypothesized that high soluble 42-amino acid β amyloid (Aβ42) peptide levels are associated with normal cognition and hippocampal volume despite increasing brain amyloidosis. Me
Externí odkaz:
https://doaj.org/article/c2d3152bfc424c28a2d7b817f273be9a
Autor:
Philip S Insel, Christina B Young, Paul S Aisen, Keith A Johnson, Reisa A Sperling, Elizabeth C Mormino, Michael C Donohue
Publikováno v:
Brain
Rates of tau accumulation in cognitively unimpaired older adults are subtle, with magnitude and spatial patterns varying in recent reports. Regional accumulation also likely varies in the degree to which accumulation is amyloid-β-dependent. Thus, th
Autor:
Christina B, Young, Joseph R, Winer, Kyan, Younes, Karly A, Cody, Tobey J, Betthauser, Sterling C, Johnson, Aaron, Schultz, Reisa A, Sperling, Michael D, Greicius, Inma, Cobos, Kathleen L, Poston, Elizabeth C, Mormino
Publikováno v:
JAMA Neurol
IMPORTANCE: Characterization of early tau deposition in individuals with preclinical Alzheimer disease (AD) is critical for prevention trials that aim to select individuals at risk for AD and halt the progression of disease. OBJECTIVE: To evaluate th