Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Christina Amat"'
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A50 MODULATION OF GOBLET CELL ACTIVITY DURING GIARDIA DUODENALIS INFECTION: A ROLE FOR PAR2
Autor: Morley D. Hollenberg, Thibault Allain, Christina Amat, Andre G. Buret, Elena Fekete, Kris Chadee, Koichiro Mihara
Publikováno v: J Can Assoc Gastroenterol
Background Giardia duodenalis has been shown to alter the structure of the intestinal mucus layers during infection via obscure mechanisms. We hypothesize that goblet cell activity may be disrupted in part due to proteolytic activation of protease-ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172b19b9e2913e44cfd945800137b0bf
https://doi.org/10.1093/jcag/gwab002.048
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Akademický článek
Development of a bicistronic anti-CD19/CD20 CAR construct including abrogation of unexpected nucleic acid sequence deletions
Autor: Norris Lam, Richard Finney, Shicheng Yang, Stephanie Choi, Xiaolin Wu, Lauren Cutmore, Jorge Andrade, Lei Huang, Christina Amatya, Margaret Cam, James N. Kochenderfer
Publikováno v: Molecular Therapy: Oncolytics, Vol 30, Iss , Pp 132-149 (2023)
To address CD19 loss from lymphoma after anti-CD19 chimeric antigen receptor (CAR) T cell therapy, we designed a bicistronic construct encoding an anti-CD19 CAR and an anti-CD20 CAR. We detected deletions from the expected bicistronic construct seque
Externí odkaz: https://doaj.org/article/8394a243d09d4dd3a0e473ce7dff27d0
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6
Akademický článek
Optimization of anti-CD19 CAR T cell production for treatment of patients with chronic lymphocytic leukemia
Autor: Christina Amatya, Katherine A. Weissler, Vicki Fellowes, Norris Lam, Lauren C. Cutmore, Danielle A. Natrakul, Steven L. Highfill, James N. Kochenderfer
Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101212- (2024)
T cells expressing anti-CD19 chimeric antigen receptors (CARs) have activity against chronic lymphocytic leukemia (CLL), but complete response rates range from 18% to 29%, so improvement is needed. Peripheral blood mononuclear cells (PBMCs) of CLL pa
Externí odkaz: https://doaj.org/article/02693419e64d4267a885aa3aa7ba3a05
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9
A7 THE ROLE OF PROTEASE-ACTIVATED RECEPTOR-2 IN GIARDIA INDUCED DISRUPTIONS OF THE INTESTINAL MUCUS LAYER
Autor: Morley D. Hollenberg, Elena Fekete, M Saiffeddine, Andre G. Buret, Kris Chadee, Christina Amat, Thibault Allain
BACKGROUND: Disruptions of the intestinal mucus barrier have been implicated in a variety of intestinal disorders. The mechanisms behind these disruptions remain unclear. We recently demonstrated that the enteric parasitic pathogen Giardia duodenalis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0483be294cc3f68b7ab22816be962dbe
https://europepmc.org/articles/PMC6508306/
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A298 A SWITCH FROM MUC2 TRANSCRIPTION TO MUC5AC IS A COMPENSATORY MECHANISM AGAINST THE MUCOLYTIC ACTIVITY OF GIARDIA DUODENALIS
Autor: Andre G. Buret, Kris Chadee, Christina Amat, Jean-Paul Motta
AIMS: Giardia duodenalis is a diarrheagenic parasite of the small intestine characterized by acute and chronic illnesses including irritable bowel syndrome. MUC5AC mucin in the stomach and MUC2 in the intestine are normally protective against pathoge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89a3d0fc774bf59de16f8c1e71e5f3a
https://europepmc.org/articles/PMC6507886/
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