Výsledky vyhledávání - "Christina A. Svitek"

The Glucose-6-Phosphatase Catalytic Subunit Gene Promoter Contains Both Positive and Negative Glucocorticoid Response Elements

Autor: James K. Oeser, Shelley R. Allen, Craig W. Vander Kooi, Walter J. Chazin, Christina A. Svitek, Hiroshi Onuma, Beth T. Vander Kooi, Richard M. O'Brien

Publikováno v: Molecular Endocrinology. 19:3001-3022

Glucose-6-phosphatase catalyzes the final step in the gluconeogenic and glycogenolytic pathways. Glucocorticoids stimulate glucose-6-phosphatase catalytic subunit (G6Pase) gene transcription and studies performed in H4IIE hepatoma cells demonstrate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa221285419d262435e13f23d836455
https://doi.org/10.1210/me.2004-0497

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Insulin-mediated activation of activator protein-1 through the mitogen-activated protein kinase pathway stimulates collagenase-1 gene transcription in the MES 13 mesangial cell line

Autor: Julio E. Ayala, James K. Oeser, Christina A. Svitek, RB Robey, Richard M. O'Brien, Stacey C. Chapman, Jared N. Boustead

Publikováno v: Journal of Molecular Endocrinology. 33:263-280

The initial stages of diabetic nephropathy are characterized, in part, by expansion of the mesangial matrix and thickening of the glomerular basement membrane which are caused by increased extracellular matrix (ECM) protein synthesis and reduced degr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85981839f16d38e55eff8fcee2712cee
https://doi.org/10.1677/jme.0.0330263

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Selective stimulation of G-6-Pase catalytic subunit but not G-6-Ptransporter gene expression by glucagon in vivo and cAMP in situ

Autor: Carrie A. Everett, Lauri A. Hornbuckle, Stephanie S. Gustavson, James K. Oeser, Cyrus C. Martin, Alan D. Cherrington, Doss W. Neal, Christina A. Svitek, Richard M. O'Brien

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 286:E795-E808

We recently compared the regulation of glucose-6-phosphatase (G-6-Pase) catalytic subunit and glucose 6-phosphate (G-6- P) transporter gene expression by insulin in conscious dogs in vivo (Hornbuckle LA, Edgerton DS, Ayala JE, Svitek CA, Neal DW, Car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc84f75b56e5260222a77f4ee1f3ea3
https://doi.org/10.1152/ajpendo.00455.2003

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The Three Insulin Response Sequences in the Glucose-6-phosphatase Catalytic Subunit Gene Promoter Are Functionally Distinct

Autor: Christina A. Svitek, Ryan S. Streeper, Beth T. Vander Kooi, David R. Powell, James K. Oeser, Richard M. O'Brien

Publikováno v: Journal of Biological Chemistry. 278:11782-11793

Glucose-6-phosphatase catalyzes the terminal step in the gluconeogenic and glycogenolytic pathways. In HepG2 cells, the maximum repression of basal glucose-6-phosphatase catalytic subunit (G6Pase) gene transcription by insulin requires two distinct p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb22cc975d72fb9588a1cad07bea3f6
https://doi.org/10.1074/jbc.m212570200

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Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein

Autor: Christina A. Svitek, Cyrus C. Martin, John C. Hutton, James K. Oeser, Richard M. O'Brien, SI Hunter

Publikováno v: Journal of Molecular Endocrinology. 29:205-222

Glucose-6-phosphatase (G6Pase) catalyzes the final step in the gluconeogenic and glycogenolytic pathways, the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate. This paper describes the identification and characterization of a human cD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee0c4a0d4d9d7398473f5a9844762ae
https://doi.org/10.1677/jme.0.0290205

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Protein Kinase A Phosphorylates Hepatocyte Nuclear Factor-6 and Stimulates Glucose-6-phosphatase Catalytic Subunit Gene Transcription

Autor: James K. Oeser, Ryan S. Streeper, Lauri A. Hornbuckle, Joshua K. Goldman, Christina A. Svitek, Richard M. O'Brien

Publikováno v: Journal of Biological Chemistry. 276:19111-19118

Glucose-6-phosphatase is a multicomponent system that catalyzes the terminal step in gluconeogenesis. To examine the effect of the cAMP signal transduction pathway on expression of the gene encoding the mouse glucose-6-phosphatase catalytic subunit (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c3e626f880aa7f5a48f9a17d11c681
https://doi.org/10.1074/jbc.m101442200

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Characterization of the Mouse Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Gene Promoter by In Situ Footprinting

Autor: John C. Hutton, Joshua K. Goldman, Larry J. Bischof, Lauri A. Hornbuckle, Beth T. Stadelmaier, James K. Oeser, Cyrus C. Martin, Christina A. Svitek, Richard M. O'Brien

Publikováno v: Diabetes. 50:502-514

Glucose-6-phosphatase (G6Pase) is a multicomponent system located in the endoplasmic reticulum comprising a catalytic subunit and transporters for glucose-6-phosphate, inorganic phosphate, and glucose. We have recently cloned a novel gene that encode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cec15b11ad28c60fd153b6430733e45
https://doi.org/10.2337/diabetes.50.3.502

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Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence

Autor: Richard M. O'Brien, Julio E. Ayala, Adisak Suwanichkul, Ryan S. Streeper, David R. Powell, Joshua K. Goldman, Christina A. Svitek, Frederic G. Barr, Jay S. Desgrosellier, Susan K. Durham

Publikováno v: Diabetes. 48:1885-1889

Because overexpression of the glucose-6-phosphatase catalytic subunit (G-6-Pase) in both type 1 and type 2 diabetes may contribute to the characteristic increased rate of hepatic glucose production, we have investigated whether the insulin response u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2833f86b60548b22af869fcc974dcc3e
https://doi.org/10.2337/diabetes.48.9.1885

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Multiple Promoter Elements Are Required for the Stimulatory Effect of Insulin on Human Collagenase-1 Gene Transcription

Autor: Julio E. Ayala, Christina A. Svitek, Ryan S. Streeper, Richard M. O'Brien, Erin M. Eaton, Jeremy M. Tavaré, Joshua K. Goldman, Stacey C. Chapman, Ainsley A. Culbert

Publikováno v: Journal of Biological Chemistry. 274:18625-18634

Several of the complications seen in patients with both type I and type II diabetes mellitus are associated with alterations in the expression of matrix metalloproteinases. To identify the cis-acting elements that mediate the stimulatory effect of in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d49b917c0b668b33c3bb615eb93fcc42
https://doi.org/10.1074/jbc.274.26.18625

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A Phorbol Ester-Insensitive AP-1 Motif Mediates the Stimulatory Effect of Insulin on Rat Malic Enzyme Gene Transcription

Autor: Julio E. Ayala, Joshua K. Goldman, Richard M. O'Brien, Stacey C. Chapman, Alex Cave, Ryan S. Streeper, Christina A. Svitek

Publikováno v: Molecular Endocrinology. 12:1778-1791

In liver, insulin stimulates the transcription of the gene encoding the cytosolic form of malic enzyme (ME) and modulates protein binding to two putative insulin response sequences (IRSs) in the ME promoter. One of these IRSs resembles that identifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68459369e7a6f087fb231843358a7c66
https://doi.org/10.1210/mend.12.11.0199

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