Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.

Autor: Andrea Nühs, Manu De Rycker, Sujatha Manthri, Eamon Comer, Christina A Scherer, Stuart L Schreiber, Jean-Robert Ioset, David W Gray

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 9, p e0004094 (2015)

Visceral leishmaniasis is an important parasitic disease of the developing world with a limited arsenal of drugs available for treatment. The existing drugs have significant deficiencies so there is an urgent need for new and improved drugs. In the h

Externí odkaz: https://doaj.org/article/cd8f4a6be22a43ea90005eb819ad4238

Distinct gene expression profiles in peripheral blood mononuclear cells from patients infected with vaccinia virus, yellow fever 17D virus, or upper respiratory infections

Autor: Kathryn V. Steiger, N. Jean Haulman, Christine M. Caputo, Douglas G. Miner, Christine Pilar, Jack T. Stapleton, Donna Klinzman, Charles L. Magness, Martha H. Gillham, Janice McKee, Patricia A. Ward, Patricia L. Winokur, Nicholas D. Poitinger, Christina A. Scherer, Shawn P. Iadonato

Publikováno v: Vaccine. 25:6458-6473

Gene expression in human peripheral blood mononuclear cells was systematically evaluated following smallpox and yellow fever vaccination, and naturally occurring upper respiratory infection (URI). All three infections were characterized by the induct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adc5acd042b55504a3e87dfcc14a4993
https://doi.org/10.1016/j.vaccine.2007.06.035

Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity

Autor: Thomas Kuri, Helle Kristiansen, Maralee Mcvean, Shawn P. Iadonato, Rune Hartmann, Friedemann Weber, Christina A. Scherer, Susanne Vends, Kristy A. Horan, Karthiga Thavachelvam, Thomas B. Steffensen, Søren R. Paludan

Publikováno v: Kristiansen, H, Scherer, C A, McVean, M, Iadonato, S P, Vends, S, Thavachelvam, K, Steffensen, T B, Horan, K A, Kuri, T, Weber, F, Paludan, S R & Hartmann, R 2010, ' Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity ', Journal of Virology, vol. 84, no. 22, pp. 11898-904 . https://doi.org/10.1128/JVI.01003-10

The 2′-5′ oligoadenylate synthetase (OAS) proteins are traditionally considered intracellular antiviral proteins. However, several studies demonstrate a correlation between the concentration of freely circulating OAS protein in sera from hepatiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17db3240cca48a783e885e7786c1cbfc
https://pure.au.dk/portal/da/publications/extracellular-25-oligoadenylate-synthetase-stimulates-rnase-lindependent-antiviral-activity-a-novel-mechanism-of-virusinduced-innate-immunity(5b9d3f0e-2ac6-41b4-96d6-4655c5c02194).html

Rac, ruffle and rho: orchestration of Salmonella invasion

Autor: Cammie F. Lesser, Christina A. Scherer, Samuel I. Miller

Publikováno v: Trends in microbiology. 8(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c964fbe58d186c4636d4df84696f8078
https://pubmed.ncbi.nlm.nih.gov/10754568

Molecular Pathogenesis of Salmonellae

Autor: Christina A. Scherer, Samuel I. Miller

Publikováno v: Principles of Bacterial Pathogenesis

In this chapter, the epidemiology, general disease course, and pathogenesis of Salmonella infections is discussed. Pathogenesis involves an interaction between both host and bacterial factors. Although the understanding of the diverse and resourceful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78ba0b924ff9261d818a70d278c12fc3
https://doi.org/10.1016/b978-012304220-0/50008-x