Multiomic profiling of the acute stress response in the mouse hippocampus

Autor: Lukas M. von Ziegler, Amalia Floriou-Servou, Rebecca Waag, Rebecca R. Das Gupta, Oliver Sturman, Katharina Gapp, Christina A. Maat, Tobias Kockmann, Han-Yu Lin, Sian N. Duss, Mattia Privitera, Laura Hinte, Ferdinand von Meyenn, Hanns U. Zeilhofer, Pierre-Luc Germain, Johannes Bohacek

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Acute stress can help individuals to respond to challenging events, although chronic stress leads to maladaptive changes. Here, the authors present a multi omic analysis profiling acute stress-induced changes in the mouse hippocampus, providing a res

Externí odkaz: https://doaj.org/article/859e65c14b6146b5b795319376098f0e

The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy

Autor: Markus Britschgi, Thomas Kremer, Klaus Kaluza, Jeroen Kole, Evelien Timmermans-Huisman, Christina A. Maat, Wagner Zago, Mirko Ritter, Olaf Mundigl, Tim Moors, Robin Barbour, Daniel Niedieker, Samir F. El-Mashtoly, Jeroen J. G. Geurts, Liz Spycher, Melanie N. Hug, Sebastian Dziadek, Klaus Gerwert, Wilma D.J. van de Berg, Sylwia Huber, Dennis Petersen, Daniel Mona

Publikováno v: Acta Neuropathologica
Moors, T E, Maat, C A, Niedieker, D, Mona, D, Petersen, D, Timmermans-Huisman, E, Kole, J, El-Mashtoly, S F, Spycher, L, Zago, W, Barbour, R, Mundigl, O, Kaluza, K, Huber, S, Hug, M N, Kremer, T, Ritter, M, Dziadek, S, Geurts, J J G, Gerwert, K, Britschgi, M & van de Berg, W D J 2021, ' The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy ', Acta Neuropathologica, vol. 142, no. 3, pp. 423-448 . https://doi.org/10.1007/s00401-021-02329-9
Acta Neuropathologica, 142(3), 423-448. Springer Verlag

Various post-translationally modified (PTM) proteoforms of alpha-synuclein (aSyn)—including C-terminally truncated (CTT) and Serine 129 phosphorylated (Ser129-p) aSyn—accumulate in Lewy bodies (LBs) in different regions of the Parkinson’s disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf63bf1622fcbd876ded3a1738020fec
https://doi.org/10.1007/s00401-021-02329-9

Multiomic profiling of the acute stress response in the mouse hippocampus

Autor: Lukas M, von Ziegler, Amalia, Floriou-Servou, Rebecca, Waag, Rebecca R, Das Gupta, Oliver, Sturman, Katharina, Gapp, Christina A, Maat, Tobias, Kockmann, Han-Yu, Lin, Sian N, Duss, Mattia, Privitera, Laura, Hinte, Ferdinand, von Meyenn, Hanns U, Zeilhofer, Pierre-Luc, Germain, Johannes, Bohacek

Publikováno v: Nature communications. 13(1)

The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. However, the underlying molecular cascades are unclear. Here, we use a brief swim exposure to trigger an acute stress response in mice, which transie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37fc2c25496de80d827f094bb2842d23
https://pubmed.ncbi.nlm.nih.gov/35383160

Broad transcriptional dysregulation of brain and choroid plexus cell types with COVID-19

Autor: Kruti Calcuttawala, Davis P. Lee, Patricia Moran Losada, Christina A. Maat, Tobias Fehlmann, Fabian Kern, Divya Channappa, Andreas Keller, David Gate, Nicole Ludwig, Andrew C. Yang, Ryan T. Vest, Walter J. Schulz-Schaeffer, Margaret Windy McNerney, Inma Cobos, Nicholas Schaum, Tony Wyss-Coray, Georges Pierre Schmartz, Daniela Berdnik

Though SARS-CoV-2 primarily targets the respiratory system, it is increasingly appreciated that patients may suffer neurological symptoms of varied severity1–3. However, an unbiased understanding of the molecular processes across brain cell types t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68d4acb084f75382f2e9b9c84497fb86
https://doi.org/10.1101/2020.10.22.349415

Subcellular orchestration of alpha-synuclein variants in Parkinson’s disease brains revealed by 3D multicolor STED microscopy

Autor: Liz Spycher, Klaus Gerwert, Tim Moors, Wagner Zago, Dennis Petersen, Christina A. Maat, Jeroen J. G. Geurts, Robin Barbour, Daniel Niedieker, Evelien Timmermans-Huisman, Klaus Kaluza, Samir F. El-Mashtoly, Wilma D.J. van de Berg, Sylwia Huber, Olaf Mundigl, Daniel Mona, Jeroen Kole, Thomas Kremer, Sebastian Dziadek, Markus Britschgi, Melanie N. Hug, Mirko Ritter

Post-translational modifications of alpha-synuclein (aSyn), particularly phosphorylation at Serine 129 (Ser129-p) and truncation of its C-terminus (CTT), have been implicated in Parkinson’s disease (PD) pathology. To gain more insight in the releva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee0a63b52b8a07ddd9e7d0c39b4122e